(48 nodes) Regulation of neural precursor cell proliferation network (Alligator mississippiensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPR56	G-protein coupled receptor 56; Belongs to the G-protein coupled receptor 2 family. (699 aa)
	SHCBP1	SHC SH2 domain-binding protein 1. (679 aa)
	CX3CL1	Fractalkine. (118 aa)
	TRIM71	E3 ubiquitin-protein ligase TRIM71. (610 aa)
	GLI1	Zinc finger protein GLI1. (476 aa)
	LYN	Tyrosine-protein kinase. (562 aa)
	TOX	Thymocyte selection-associated high mobility group box protein TOX. (526 aa)
	FAM19A1	Protein FAM19A1. (105 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	KIFAP3	Kinesin-associated protein 3. (793 aa)
	Y1Q_0003064	Protein CIP2A. (877 aa)
	PAX6	Paired box protein Pax-6. (516 aa)
	MDK	Midkine. (156 aa)
	PTBP2	Uncharacterized protein. (537 aa)
	DISC1-1	Disrupted in schizophrenia 1 protein isoform A. (626 aa)
	OTP	Homeobox protein orthopedia. (325 aa)
	ZMPSTE24	CAAX prenyl protease 1-like protein. (1233 aa)
	PTPRZ1	Protein-tyrosine-phosphatase. (1295 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
	CTNNB1	Catenin beta-1 isoform B. (783 aa)
	GLI3	Uncharacterized protein. (1572 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (632 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1759 aa)
	CEND1	Cell cycle exit and neuronal differentiation protein 1. (134 aa)
	LIMS1-2	LIM domain-containing protein. (387 aa)
	LIMS1	LIM domain-containing protein. (375 aa)
	SMO	Smoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (804 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
	PTN	Pleiotrophin. (165 aa)
	APPL2	Uncharacterized protein. (659 aa)
	DRD2	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (434 aa)
	BTG2	Protein BTG2. (152 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
	ID2	DNA-binding protein inhibitor ID-2. (134 aa)
	NF1	Neurofibromin isoform B. (2879 aa)
	LHX1-2	Uncharacterized protein. (406 aa)
	Y1Q_0007089	FERM domain-containing protein. (665 aa)
	LHX1	LIM/homeobox protein Lhx1. (402 aa)
	NF2	Merlin isoform A. (593 aa)
	PTCHD2	Patched domain-containing protein 2 isoform A. (1339 aa)
	ZNF335	Zinc finger protein 335 isoform B. (1362 aa)
	Y1Q_0018485	Paired box protein Pax-6-like. (281 aa)
	ILK	Integrin-linked protein kinase. (452 aa)
	FOXG1	Forkhead box protein G1. (172 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (687 aa)
	SPINT1	Kunitz-type protease inhibitor 1. (473 aa)
	FAM19A3	Protein FAM19A3. (196 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTG2	TP53	A0A151NBT9	A0A151MW63	Protein BTG2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.471
CTNNB1	FOXG1	A0A151P2N9	A0A151MW87	Catenin beta-1 isoform B.	Forkhead box protein G1.	0.623
CTNNB1	FZD3	A0A151P2N9	A0A151P1W7	Catenin beta-1 isoform B.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.500
CTNNB1	GLI1	A0A151P2N9	A0A151MRB2	Catenin beta-1 isoform B.	Zinc finger protein GLI1.	0.491
CTNNB1	ILK	A0A151P2N9	A0A151MYS5	Catenin beta-1 isoform B.	Integrin-linked protein kinase.	0.418
CTNNB1	NF2	A0A151P2N9	A0A151N4S8	Catenin beta-1 isoform B.	Merlin isoform A.	0.400
CTNNB1	SIRT2	A0A151P2N9	A0A151PIM0	Catenin beta-1 isoform B.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.550
CTNNB1	SMO	A0A151P2N9	A0A151NPV6	Catenin beta-1 isoform B.	Smoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.427
CTNNB1	TP53	A0A151P2N9	A0A151MW63	Catenin beta-1 isoform B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.586
CTNNB1	Y1Q_0007089	A0A151P2N9	A0A151N5I2	Catenin beta-1 isoform B.	FERM domain-containing protein.	0.400
CTNNB1	ZMPSTE24	A0A151P2N9	A0A151PGE7	Catenin beta-1 isoform B.	CAAX prenyl protease 1-like protein.	0.435
DISC1-1	DRD2	A0A151M2P5	A0A151NFV7	Disrupted in schizophrenia 1 protein isoform A.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.678
DRD2	DISC1-1	A0A151NFV7	A0A151M2P5	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	Disrupted in schizophrenia 1 protein isoform A.	0.678
FOXG1	CTNNB1	A0A151MW87	A0A151P2N9	Forkhead box protein G1.	Catenin beta-1 isoform B.	0.623
FOXG1	LHX1	A0A151MW87	A0A151N4U0	Forkhead box protein G1.	LIM/homeobox protein Lhx1.	0.425
FOXG1	NES	A0A151MW87	A0A151NY65	Forkhead box protein G1.	Nestin; Belongs to the intermediate filament family.	0.574
FOXG1	NR2E1	A0A151MW87	A0A151MJX7	Forkhead box protein G1.	Nuclear receptor subfamily 2 group E member 1.	0.420
FOXG1	OTP	A0A151MW87	A0A151PHN8	Forkhead box protein G1.	Homeobox protein orthopedia.	0.530
FOXG1	PAX6	A0A151MW87	A0A151MBV0	Forkhead box protein G1.	Paired box protein Pax-6.	0.659
FOXG1	SIRT2	A0A151MW87	A0A151PIM0	Forkhead box protein G1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.559