(88 nodes) Tyrosine-specific protein phosphatases domain network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DUSP11	RNA/RNP complex-1-interacting phosphatase. (333 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
	DUSP19	Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (178 aa)
	PTPN4	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (953 aa)
	PTPRM	Receptor-type tyrosine-protein phosphatase mu isoform C. (1440 aa)
	DUSP7	Dual specificity protein phosphatase 7. (289 aa)
	Y1Q_0007467	Uncharacterized protein. (552 aa)
	DUSP9	Dual specificity protein phosphatase 9. (429 aa)
	Y1Q_0015214	Uncharacterized protein. (749 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (336 aa)
	CDC14A	Dual specificity protein phosphatase CDC14A isoform A. (493 aa)
	PTPRA	Receptor-type tyrosine-protein phosphatase alpha isoform A. (1898 aa)
	PTPN9	Tyrosine-protein phosphatase non-receptor type 9. (584 aa)
	PTPMT1	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1. (195 aa)
	PTPN5	Tyrosine-protein phosphatase non-receptor type 5. (448 aa)
	Y1Q_0000759	Uncharacterized protein. (251 aa)
	PTPRJ	Receptor-type tyrosine-protein phosphatase eta isoform A. (1187 aa)
	DUSP8	Dual specificity protein phosphatase 8 isoform A. (623 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
	DUSP27	Inactive dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1173 aa)
	DUSP15	Dual specificity protein phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (223 aa)
	PTPRG	Protein-tyrosine-phosphatase. (879 aa)
	PTPN20	Tyrosine-protein phosphatase non-receptor type 20 isoform A. (2367 aa)
	PTP4A2	Protein tyrosine phosphatase type IVA 2. (167 aa)
	PTPN23	Tyrosine-protein phosphatase non-receptor type 23. (1589 aa)
	Y1Q_0012288	Uncharacterized protein. (180 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
	DUSP13	Dual specificity protein phosphatase 13 isoform A; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (439 aa)
	DUPD1	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (214 aa)
	Y1Q_0005181	Dual specificity protein phosphatase 26-like; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (309 aa)
	RNGTT	Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (601 aa)
	SSH3	Phosphatase Slingshot-like protein 3 isoform A. (1229 aa)
	PTPRA-2	Uncharacterized protein. (1013 aa)
	PTPDC1-1	Protein tyrosine phosphatase domain-containing protein 1 isoform B. (424 aa)
	SSH1	Phosphatase Slingshot-like protein 1. (1358 aa)
	PTPN18	Tyrosine-protein phosphatase non-receptor type 18. (493 aa)
	Y1Q_0006103	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	DUSP18	Dual specificity protein phosphatase 18; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
	STYXL1	Serine/threonine/tyrosine-interacting-like protein 1. (305 aa)
	DUSP14	Dual specificity protein phosphatase 14; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (198 aa)
	MTM1-2	Uncharacterized protein. (603 aa)
	MTMR1	Uncharacterized protein. (655 aa)
	PTPRB	Receptor-type tyrosine-protein phosphatase beta. (2275 aa)
	PTPN7	Tyrosine-protein phosphatase non-receptor type 7. (339 aa)
	TPTE2	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2. (511 aa)
	DUSP23	Dual specificity protein phosphatase 23. (227 aa)
	DUSP26	Dual specificity protein phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (245 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform D. (1209 aa)
	PTPRM-2	Uncharacterized protein. (1418 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (429 aa)
	DUSP22	Dual specificity protein phosphatase 22 isoform A; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (206 aa)
	PTPN22	Tyrosine-protein phosphatase non-receptor type 22 isoform B. (579 aa)
	PTPRO	Receptor-type tyrosine-protein phosphatase O isoform B. (1189 aa)
	GAK	Cyclin-G-associated kinase isoform A. (878 aa)
	PTPRN-2	Uncharacterized protein. (281 aa)
	EPM2A	Laforin. (305 aa)
	Y1Q_0010362	Dual specificity protein phosphatase 22-A. (380 aa)
	PTPN13	Tyrosine-protein phosphatase non-receptor type 13 isoform C. (2492 aa)
	PTPN12	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (744 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	SSH1-2	Uncharacterized protein. (1082 aa)
	Y1Q_0015722	Receptor-type tyrosine-protein phosphatase T-like. (566 aa)
	MTMR4	Myotubularin-related protein 4 isoform A. (1123 aa)
	DUSP28	Dual specificity phosphatase 28. (144 aa)
	DUSP5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	PTPRT	Uncharacterized protein. (1414 aa)
	Y1Q_0022158	TYR_PHOSPHATASE_2 domain-containing protein. (713 aa)
	PTPRS	Uncharacterized protein. (1911 aa)
	MTM1	Myotubularin isoform B. (650 aa)
	PTPN14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1182 aa)
	DUSP10	Dual specificity protein phosphatase 10. (479 aa)
	PTPRE	Receptor-type tyrosine-protein phosphatase epsilon isoform A. (401 aa)
	DUSP16	Dual specificity protein phosphatase 16. (664 aa)
	PTP4A3	Protein tyrosine phosphatase type IVA 3. (173 aa)
	PTPN21	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1181 aa)
	MTMR7	Uncharacterized protein. (660 aa)
	DUSP3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
	PTPRN	Receptor-type tyrosine-protein phosphatase-like N. (422 aa)
	PTP4A1	Protein tyrosine phosphatase type IVA 1. (170 aa)
	STYX	Serine/threonine/tyrosine-interacting protein. (223 aa)
	PTPRZ1	Protein-tyrosine-phosphatase. (1295 aa)
	PTPRR	Receptor-type tyrosine-protein phosphatase R. (2872 aa)
	PTPRQ	Phosphatidylinositol phosphatase PTPRQ isoform G. (5845 aa)
	PTPRU	Uncharacterized protein. (1507 aa)
	TNS3	Tensin-3 isoform E. (1563 aa)
	PTPN3	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (939 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC14A	Y1Q_0007467	A0A151M838	A0A151M4U9	Dual specificity protein phosphatase CDC14A isoform A.	Uncharacterized protein.	0.449
DUSP3	EPM2A	A0A151PBK6	A0A151NLS3	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Laforin.	0.400
DUSP3	PTPN5	A0A151PBK6	A0A151MC61	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein phosphatase non-receptor type 5.	0.905
DUSP3	PTPN7	A0A151PBK6	A0A151N9F8	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Tyrosine-protein phosphatase non-receptor type 7.	0.926
DUSP6	DUSP9	A0A151LYT1	A0A151M561	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity protein phosphatase 9.	0.523
DUSP7	DUSP9	A0A151M3T4	A0A151M561	Dual specificity protein phosphatase 7.	Dual specificity protein phosphatase 9.	0.500
DUSP9	DUSP6	A0A151M561	A0A151LYT1	Dual specificity protein phosphatase 9.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.523
DUSP9	DUSP7	A0A151M561	A0A151M3T4	Dual specificity protein phosphatase 9.	Dual specificity protein phosphatase 7.	0.500
EPM2A	DUSP3	A0A151NLS3	A0A151PBK6	Laforin.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.400
MTMR4	MTMR7	A0A151NTP7	A0A151PBD0	Myotubularin-related protein 4 isoform A.	Uncharacterized protein.	0.407
MTMR4	RNGTT	A0A151NTP7	A0A151MTU5	Myotubularin-related protein 4 isoform A.	Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.	0.539
MTMR7	MTMR4	A0A151PBD0	A0A151NTP7	Uncharacterized protein.	Myotubularin-related protein 4 isoform A.	0.407
PTPN11	PTPN6	A0A151NSB1	A0A151MCT9	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.501
PTPN11	Y1Q_0006103	A0A151NSB1	A0A151N4C4	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
PTPN23	Y1Q_0012288	A0A151MPK8	A0A151MPR4	Tyrosine-protein phosphatase non-receptor type 23.	Uncharacterized protein.	0.920
PTPN5	DUSP3	A0A151MC61	A0A151PBK6	Tyrosine-protein phosphatase non-receptor type 5.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.905
PTPN5	PTPN7	A0A151MC61	A0A151N9F8	Tyrosine-protein phosphatase non-receptor type 5.	Tyrosine-protein phosphatase non-receptor type 7.	0.943
PTPN6	PTPN11	A0A151MCT9	A0A151NSB1	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.501
PTPN6	Y1Q_0006103	A0A151MCT9	A0A151N4C4	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.499
PTPN7	DUSP3	A0A151N9F8	A0A151PBK6	Tyrosine-protein phosphatase non-receptor type 7.	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.926