(45 nodes) ATPase, AAA-type, core network (Alligator mississippiensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCS1L	Mitochondrial chaperone BCS1; Belongs to the AAA ATPase family. (471 aa)
	ORC1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (949 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	CLPX	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial. (895 aa)
	SPATA5L1	Spermatogenesis-associated protein 5-like protein 1. (763 aa)
	PSMC3	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
	PEX6	Peroxisome biogenesis factor 6. (770 aa)
	SPAST	Spastin; Belongs to the AAA ATPase family. (485 aa)
	PEX1	Peroxisome biogenesis factor 1 isoform A. (1279 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (873 aa)
	FIGNL2	Putative fidgetin-like protein 2; Belongs to the AAA ATPase family. (738 aa)
	KATNAL1	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. (565 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (542 aa)
	ATAD2B	ATPase family AAA domain-containing protein 2B. (1982 aa)
	CHTF18	Chromosome transmission fidelity 18-like protein isoform B. (1021 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1673 aa)
	ATAD3A	ATPase family AAA domain-containing protein 3A. (518 aa)
	RFC5	Replication factor C subunit 5. (336 aa)
	RFC2	Replication factor C subunit 2. (340 aa)
	NSF	Vesicle-fusing ATPase. (742 aa)
	IQCA1	IQ and AAA domain-containing protein 1 isoform C. (968 aa)
	PSMC5	Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
	LONP1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (844 aa)
	AFG3L2	AFG3-like protein 2 isoform B. (808 aa)
	WRNIP1	ATPase WRNIP1. (519 aa)
	VPS4B-2	Uncharacterized protein; Belongs to the AAA ATPase family. (463 aa)
	PSMC4	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (532 aa)
	Y1Q_0018247	ATPase_AAA_core domain-containing protein. (309 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (463 aa)
	PSMC2	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
	VCP	Uncharacterized protein; Belongs to the AAA ATPase family. (880 aa)
	ATAD1	ATPase family AAA domain-containing protein 1; Belongs to the AAA ATPase family. (409 aa)
	FIGNL1	Fidgetin-like protein 1. (1085 aa)
	NVL	Nuclear valosin-containing protein-like. (853 aa)
	SPG7	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (1069 aa)
	PSMC1	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
	RFC1	Replication factor C subunit 1. (1130 aa)
	YME1L1	ATP-dependent zinc metalloprotease YME1L1 isoform A. (724 aa)
	PSMC6	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
	SPATA5	Spermatogenesis-associated protein 5. (871 aa)
	NAV3-2	Calponin-homology (CH) domain-containing protein. (2237 aa)
	TRIP13	Pachytene checkpoint 2-like protein; Belongs to the AAA ATPase family. (432 aa)
	ATAD2B-2	Bromo domain-containing protein. (1418 aa)
	CLPB	Caseinolytic peptidase B protein-like protein. (610 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	CLPB	A0A151NF88	A0A151PJK6	AFG3-like protein 2 isoform B.	Caseinolytic peptidase B protein-like protein.	0.410
AFG3L2	CLPX	A0A151NF88	A0A151M8Z4	AFG3-like protein 2 isoform B.	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial.	0.691
AFG3L2	LONP1	A0A151NF88	A0A151NCD1	AFG3-like protein 2 isoform B.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-.	0.553
AFG3L2	LONP2	A0A151NF88	A0A151MRX3	AFG3-like protein 2 isoform B.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-.	0.532
AFG3L2	SPG7	A0A151NF88	A0A151P4L2	AFG3-like protein 2 isoform B.	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family.	0.781
AFG3L2	YME1L1	A0A151NF88	A0A151PCQ1	AFG3-like protein 2 isoform B.	ATP-dependent zinc metalloprotease YME1L1 isoform A.	0.423
ATAD2B	ORC1	A0A151MXR5	A0A151M4M2	ATPase family AAA domain-containing protein 2B.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.456
ATAD2B	PSMC3	A0A151MXR5	A0A151MB32	ATPase family AAA domain-containing protein 2B.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.610
ATAD2B	PSMC4	A0A151MXR5	A0A151NHC2	ATPase family AAA domain-containing protein 2B.	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family.	0.610
ATAD2B	PSMC6	A0A151MXR5	A0A151PDY8	ATPase family AAA domain-containing protein 2B.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.610
ATAD2B-2	ORC1	A0A151PIR4	A0A151M4M2	Bromo domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.456
ATAD2B-2	PSMC3	A0A151PIR4	A0A151MB32	Bromo domain-containing protein.	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family.	0.610
ATAD2B-2	PSMC4	A0A151PIR4	A0A151NHC2	Bromo domain-containing protein.	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family.	0.610
ATAD2B-2	PSMC6	A0A151PIR4	A0A151PDY8	Bromo domain-containing protein.	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.610
ATAD5	CHTF18	A0A151N2M2	A0A151N236	ATPase family AAA domain-containing protein 5.	Chromosome transmission fidelity 18-like protein isoform B.	0.901
ATAD5	ORC1	A0A151N2M2	A0A151M4M2	ATPase family AAA domain-containing protein 5.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.791
ATAD5	RFC1	A0A151N2M2	A0A151P9W6	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 1.	0.706
ATAD5	RFC2	A0A151N2M2	A0A151N5C2	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 2.	0.976
ATAD5	RFC4	A0A151N2M2	A0A151M684	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 4.	0.982
ATAD5	RFC5	A0A151N2M2	A0A151N4L9	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 5.	0.981