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Y1Q_0011941 Y1Q_0011941 KCNA4 KCNA4 KCNQ1 KCNQ1 CACNA1B CACNA1B CACNA1E-2 CACNA1E-2 ITPR2 ITPR2 CACNA1A CACNA1A HCN4 HCN4 CNGA1 CNGA1 KCNB2-2 KCNB2-2 TRPA1 TRPA1 ITPR2-2 ITPR2-2 TRPC4 TRPC4 KCNH8-2 KCNH8-2 SCN8A SCN8A KCNMA1-2 KCNMA1-2 HCN3 HCN3 KCND3-2 KCND3-2 DDX43 DDX43 RYR3 RYR3 HCN1-2 HCN1-2 KCNV1 KCNV1 KCNS2 KCNS2 KCNH2-2 KCNH2-2 CACNA1D CACNA1D CACNA1I CACNA1I Y1Q_0016435 Y1Q_0016435 TPCN1 TPCN1 KCNF1 KCNF1 KCNA2 KCNA2 KCNA10-2 KCNA10-2 KCNC4 KCNC4 KCNA10 KCNA10 CACNA1E CACNA1E TRPM8 TRPM8 TRPV4L TRPV4L TRPV2-2 TRPV2-2 TRPV2 TRPV2 KCNC1 KCNC1 KCNA7 KCNA7 KCNMA1 KCNMA1 TPTE2 TPTE2 Y1Q_0014532 Y1Q_0014532 KCNG2-2 KCNG2-2 CATSPER4 CATSPER4 TRPM5 TRPM5 Y1Q_0024060 Y1Q_0024060 CACNA1C CACNA1C Y1Q_0008405 Y1Q_0008405 Y1Q_0015244 Y1Q_0015244 TRPV6 TRPV6 KCNG2 KCNG2 CNGA2-2 CNGA2-2 Y1Q_0015599 Y1Q_0015599 TRPC5 TRPC5 NALCN-2 NALCN-2 NALCN NALCN HVCN1 HVCN1 CATSPER1 CATSPER1 Y1Q_0006258 Y1Q_0006258 KCNQ2-2 KCNQ2-2 SLC9C2 SLC9C2 KCNS1 KCNS1 KCNG1 KCNG1 KCNB2 KCNB2 HCN1 HCN1 KCNH3 KCNH3 CATSPER2 CATSPER2 KCNS3A KCNS3A CACNA1F CACNA1F Y1Q_0006643 Y1Q_0006643 KCNQ2 KCNQ2 KCND3 KCND3 KCNC2 KCNC2 Y1Q_0019676 Y1Q_0019676 TRPC3-2 TRPC3-2 Y1Q_0014536 Y1Q_0014536 Y1Q_0013976 Y1Q_0013976 Y1Q_0014535 Y1Q_0014535 Y1Q_0014534 Y1Q_0014534 KCNH1 KCNH1 ITPR3 ITPR3 KCNA6 KCNA6 KCNA1 KCNA1 Y1Q_0006979 Y1Q_0006979 Y1Q_0016832 Y1Q_0016832 KCNQ1L KCNQ1L TRPC6 TRPC6 TRPN1 TRPN1 CNGA2 CNGA2 KCNH4 KCNH4 SCN4A SCN4A KCNH8 KCNH8 trpv4 trpv4 Y1Q_0011553 Y1Q_0011553 Y1Q_0011551 Y1Q_0011551 Y1Q_0011560 Y1Q_0011560 SCN2A SCN2A KCNH2 KCNH2 TPCN3 TPCN3 KCNH5 KCNH5 RYR2 RYR2 TRPC3 TRPC3 CATSPER3 CATSPER3 KCND1 KCND1 TRPM6 TRPM6 KCNV2 KCNV2 Y1Q_0001439 Y1Q_0001439 TMEM266 TMEM266 TRPM1 TRPM1 TPCN2 TPCN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y1Q_0011941Uncharacterized protein; Belongs to the potassium channel family. (460 aa)
KCNA4BTB domain-containing protein; Belongs to the potassium channel family. (660 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1 isoform A; Belongs to the potassium channel family. (692 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2363 aa)
CACNA1E-2Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2286 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (1680 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2207 aa)
HCN4Cyclic nucleotide-binding domain-containing protein. (770 aa)
CNGA1cGMP-gated cation channel alpha-1; Belongs to the G-protein coupled receptor 1 family. (839 aa)
KCNB2-2Ion_trans domain-containing protein; Belongs to the potassium channel family. (715 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1114 aa)
ITPR2-2Uncharacterized protein. (2702 aa)
TRPC4Short transient receptor potential channel 4; Belongs to the transient receptor (TC 1.A.4) family. (975 aa)
KCNH8-2Uncharacterized protein. (816 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2018 aa)
KCNMA1-2Uncharacterized protein. (1058 aa)
HCN3Cyclic nucleotide-binding domain-containing protein. (628 aa)
KCND3-2BTB domain-containing protein; Belongs to the potassium channel family. (657 aa)
DDX43Putative ATP-dependent RNA helicase DDX43 isoform A; Belongs to the potassium channel family. (1037 aa)
RYR3Ryanodine receptor 3 isoform E. (4559 aa)
HCN1-2Cyclic nucleotide-binding domain-containing protein. (507 aa)
KCNV1Potassium voltage-gated channel subfamily V member 1; Belongs to the potassium channel family. (410 aa)
KCNS2Potassium voltage-gated channel subfamily S member 2; Belongs to the potassium channel family. (477 aa)
KCNH2-2Cyclic nucleotide-binding domain-containing protein. (1019 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha-1I isoform B. (2248 aa)
Y1Q_0016435Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1961 aa)
TPCN1Two pore calcium channel protein 1. (802 aa)
KCNF1Potassium voltage-gated channel subfamily F member 1 isoform A; Belongs to the potassium channel family. (489 aa)
KCNA2BTB domain-containing protein; Belongs to the potassium channel family. (499 aa)
KCNA10-2BTB domain-containing protein; Belongs to the potassium channel family. (520 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (595 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (574 aa)
CACNA1EVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1843 aa)
TRPM8Uncharacterized protein. (1065 aa)
TRPV4LTransient receptor potential cation channel subfamily V member 4 isoform B; Belongs to the transient receptor (TC 1.A.4) family. (773 aa)
TRPV2-2ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (773 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (786 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (396 aa)
KCNA7BTB domain-containing protein; Belongs to the potassium channel family. (485 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform E. (1062 aa)
TPTE2Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2. (511 aa)
Y1Q_0014532Uncharacterized protein. (1758 aa)
KCNG2-2BTB domain-containing protein; Belongs to the potassium channel family. (517 aa)
CATSPER4Cation channel sperm-associated protein 4 isoform B. (521 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1476 aa)
Y1Q_0024060Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2005 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1954 aa)
Y1Q_0008405Ion_trans domain-containing protein. (678 aa)
Y1Q_0015244ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (735 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (725 aa)
KCNG2Potassium voltage-gated channel subfamily G member 2; Belongs to the potassium channel family. (510 aa)
CNGA2-2Cyclic nucleotide-binding domain-containing protein. (717 aa)
Y1Q_0015599Potassium voltage-gated channel subfamily C member 1-like; Belongs to the potassium channel family. (431 aa)
TRPC5Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (989 aa)
NALCN-2Uncharacterized protein. (1096 aa)
NALCNSodium leak channel non-selective protein. (639 aa)
HVCN1Voltage-gated hydrogen channel 1. (239 aa)
CATSPER1Cation channel sperm-associated protein 1. (310 aa)
Y1Q_0006258Cyclic nucleotide-binding domain-containing protein. (673 aa)
KCNQ2-2Uncharacterized protein; Belongs to the potassium channel family. (901 aa)
SLC9C2Sodium/hydrogen exchanger 11. (1175 aa)
KCNS1Potassium voltage-gated channel subfamily S member 1 isoform A; Belongs to the potassium channel family. (507 aa)
KCNG1Uncharacterized protein; Belongs to the potassium channel family. (533 aa)
KCNB2Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (674 aa)
HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (794 aa)
KCNH3Potassium voltage-gated channel subfamily H member 3. (686 aa)
CATSPER2Cation channel sperm-associated protein 2. (578 aa)
KCNS3APotassium voltage-gated channel subfamily S member 3; Belongs to the potassium channel family. (555 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1276 aa)
Y1Q_0006643Ca_chan_IQ domain-containing protein. (672 aa)
KCNQ2Potassium voltage-gated channel subfamily KQT member 2 isoform A; Belongs to the potassium channel family. (682 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (346 aa)
KCNC2Ion_trans domain-containing protein; Belongs to the potassium channel family. (497 aa)
Y1Q_0019676Uncharacterized protein; Belongs to the potassium channel family. (301 aa)
TRPC3-2ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (923 aa)
Y1Q_0014536Uncharacterized protein. (1245 aa)
Y1Q_0013976Ion_trans domain-containing protein; Belongs to the potassium channel family. (100 aa)
Y1Q_0014535Uncharacterized protein. (315 aa)
Y1Q_0014534Uncharacterized protein. (1079 aa)
KCNH1Potassium voltage-gated channel subfamily H member 1. (959 aa)
ITPR3Uncharacterized protein. (2667 aa)
KCNA6Uncharacterized protein; Belongs to the potassium channel family. (485 aa)
KCNA1BTB domain-containing protein; Belongs to the potassium channel family. (493 aa)
Y1Q_0006979Uncharacterized protein. (520 aa)
Y1Q_0016832BTB domain-containing protein; Belongs to the potassium channel family. (514 aa)
KCNQ1LPotassium voltage-gated channel subfamily KQT member 1 isoform C; Belongs to the potassium channel family. (477 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (900 aa)
TRPN1Transient receptor potential cation channel, subfamily N, member 1 isoform B; Belongs to the transient receptor (TC 1.A.4) family. (1624 aa)
CNGA2Cyclic nucleotide-gated olfactory channel. (1430 aa)
KCNH4Potassium voltage-gated channel subfamily H member 4 isoform B. (1239 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1697 aa)
KCNH8Potassium voltage-gated channel subfamily H member 8 isoform A. (1163 aa)
trpv4Transient receptor potential cation channel subfamily V member 4 isoform A; Belongs to the transient receptor (TC 1.A.4) family. (857 aa)
Y1Q_0011553Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1910 aa)
Y1Q_0011551Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1855 aa)
Y1Q_0011560Uncharacterized protein. (1595 aa)
SCN2AUncharacterized protein. (1805 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2 isoform B. (1103 aa)
TPCN3Two-pore calcium channel 3. (755 aa)
KCNH5Uncharacterized protein. (989 aa)
RYR2Uncharacterized protein. (5012 aa)
TRPC3Short transient receptor potential channel 3 isoform B; Belongs to the transient receptor (TC 1.A.4) family. (858 aa)
CATSPER3Cation channel sperm-associated protein 3 isoform A. (403 aa)
KCND1BTB domain-containing protein; Belongs to the potassium channel family. (624 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6 isoform A. (2037 aa)
KCNV2Potassium voltage-gated channel subfamily V member 2; Belongs to the potassium channel family. (570 aa)
Y1Q_0001439Transient receptor potential cation channel subfamily M member 7-like. (1806 aa)
TMEM266Ion_trans domain-containing protein. (533 aa)
TRPM1Uncharacterized protein. (1577 aa)
TPCN2Two pore calcium channel protein 2 isoform A. (1408 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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