STRINGSTRING
ITCH-2 ITCH-2 NRAS NRAS Y1Q_0022623 Y1Q_0022623 WWP1 WWP1 GFAP GFAP MXD4-1 MXD4-1 PSEN1-1 PSEN1-1 Y1Q_0006325 Y1Q_0006325 KXD1 KXD1 PSENEN PSENEN NRG2 NRG2 NRG2-2 NRG2-2 Y1Q_0015649 Y1Q_0015649 Y1Q_0010299 Y1Q_0010299 WWOX WWOX ESR1 ESR1 KRAS-1 KRAS-1 KRAS-2 KRAS-2 ADAP1 ADAP1 NRG1-1 NRG1-1 EREG EREG BTC BTC GRB2 GRB2 ADAP2 ADAP2 ADAP1-2 ADAP1-2 Y1Q_0005265 Y1Q_0005265 NRG3 NRG3 Y1Q_0016612 Y1Q_0016612 Y1Q_0018542 Y1Q_0018542 FNDC3A-2 FNDC3A-2 RPS27A RPS27A FNDC3A FNDC3A APH1A-1 APH1A-1 NRG4 NRG4 NCSTN NCSTN Y1Q_0010680 Y1Q_0010680 PIK3CB PIK3CB SOS1-2 SOS1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITCH-2E3 ubiquitin-protein ligase. (832 aa)
NRASGTPase NRas. (189 aa)
Y1Q_0022623SWIM-type domain-containing protein. (573 aa)
WWP1E3 ubiquitin-protein ligase. (946 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (447 aa)
MXD4-1Max dimerization protein 4 isoform B. (205 aa)
PSEN1-1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
Y1Q_0006325Uncharacterized protein. (188 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
PSENENGamma-secretase subunit PEN-2 isoform A. (81 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform D. (675 aa)
NRG2-2Uncharacterized protein. (261 aa)
Y1Q_0015649Uncharacterized protein. (1191 aa)
Y1Q_0010299Uncharacterized protein. (88 aa)
WWOXWW domain-containing oxidoreductase isoform B. (440 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
KRAS-1GTPase KRas. (215 aa)
KRAS-2GTPase KRas. (219 aa)
ADAP1Arf-GAP with dual PH domain-containing protein 1. (419 aa)
NRG1-1Pro-neuregulin-1, membrane-bound isoform C. (636 aa)
EREGProepiregulin. (159 aa)
BTCProbetacellulin. (170 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ADAP2Arf-GAP with dual PH domain-containing protein 2. (366 aa)
ADAP1-2Uncharacterized protein. (375 aa)
Y1Q_0005265Uncharacterized protein. (212 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform A. (353 aa)
Y1Q_0016612Uncharacterized protein. (94 aa)
Y1Q_0018542Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
FNDC3A-2Uncharacterized protein. (1195 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1011 aa)
APH1A-1Gamma-secretase subunit APH-1A isoform A. (291 aa)
NRG4Pro-neuregulin-4, membrane-bound. (115 aa)
NCSTNNicastrin. (718 aa)
Y1Q_0010680Uncharacterized protein. (176 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOS1-2Son of sevenless-like protein. (1379 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.