STRINGSTRING
NCOR1 NCOR1 Y1Q_0018253 Y1Q_0018253 PCSK4 PCSK4 CCNT2 CCNT2 ITGB3 ITGB3 PCSK4-2 PCSK4-2 STUB1 STUB1 MEN1 MEN1 Y1Q_0008635 Y1Q_0008635 Y1Q_0008637 Y1Q_0008637 ITGAV-2 ITGAV-2 PARD3B PARD3B TFDP2 TFDP2 SKI SKI IRX4 IRX4 IRX1 IRX1 IRX2 IRX2 TGIF1 TGIF1 LDLRAD4 LDLRAD4 STRAP STRAP PARD6A PARD6A LTBP2-2 LTBP2-2 LTBP3 LTBP3 ATP1B4 ATP1B4 USP9X USP9X Y1Q_0018673 Y1Q_0018673 SCARB1 SCARB1 CCNC CCNC MTMR4 MTMR4 KXD1 KXD1 LTBP4 LTBP4 ARHGEF28 ARHGEF28 PMEPA1-1 PMEPA1-1 Y1Q_0002693 Y1Q_0002693 JUNB JUNB TGFB1 TGFB1 TGIF2 TGIF2 PARP1 PARP1 SMAD4 SMAD4 TGFBR1 TGFBR1 E2F5 E2F5 PARD3 PARD3 BAMBI BAMBI MKX MKX ITGB3-2 ITGB3-2 CCNK CCNK SP1 SP1 UBE2M UBE2M TGFB2 TGFB2 ITGB5 ITGB5 TGFBR2 TGFBR2 FAM58A FAM58A CGN CGN SNW1 SNW1 MEIS3 MEIS3 NEDD8 NEDD8 SMAD3 SMAD3 FBN1 FBN1 RNF111-1 RNF111-1 CDK9 CDK9 SKIL SKIL RPS27A RPS27A MEIS1 MEIS1 LTBP2 LTBP2 TGFB3 TGFB3 F11R F11R ITGB8-1 ITGB8-1 TGFBR2-2 TGFBR2-2 IRX5 IRX5 IRX6-1 IRX6-1 IRX3 IRX3 CCNT1 CCNT1 MEIS2 MEIS2 Y1Q_0009747 Y1Q_0009747 SMAD2-2 SMAD2-2 SMAD7 SMAD7 SMURF1 SMURF1 SMURF2 SMURF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCOR1Nuclear receptor corepressor 1 isoform B. (2411 aa)
Y1Q_0018253Uncharacterized protein; Belongs to the peptidase S8 family. (460 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (578 aa)
CCNT2Cyclin-T2 isoform B; Belongs to the cyclin family. (351 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
PCSK4-2Uncharacterized protein. (188 aa)
STUB1E3 ubiquitin-protein ligase CHIP isoform A. (339 aa)
MEN1Menin. (456 aa)
Y1Q_0008635Par3_HAL_N_term domain-containing protein. (198 aa)
Y1Q_0008637Uncharacterized protein. (521 aa)
ITGAV-2Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
PARD3BPartitioning defective 3-like protein B. (796 aa)
TFDP2Transcription factor. (447 aa)
SKISki oncogene isoform A. (637 aa)
IRX4Iroquois-class homeodomain protein IRX-4. (449 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (307 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (321 aa)
TGIF1Homeobox protein TGIF1. (268 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4. (310 aa)
STRAPSerine-threonine kinase receptor-associated protein. (350 aa)
PARD6APartitioning defective 6-like protein alpha. (367 aa)
LTBP2-2Uncharacterized protein. (1551 aa)
LTBP3Uncharacterized protein. (620 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (321 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2552 aa)
Y1Q_0018673Uncharacterized protein. (2454 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
CCNCCyclin-C; Belongs to the cyclin family. (283 aa)
MTMR4Myotubularin-related protein 4 isoform A. (1123 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4. (1231 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform B. (1520 aa)
PMEPA1-1Protein TMEPAI isoform B. (238 aa)
Y1Q_0002693Uncharacterized protein. (87 aa)
JUNBTranscription factor jun-B. (292 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
TGIF2Homeobox protein TGIF2. (295 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
E2F5Transcription factor E2F5. (386 aa)
PARD3Partitioning defective 3-like protein isoform A. (1225 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
MKXHomeobox protein Mohawk. (352 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
CCNKCyclin-K; Belongs to the cyclin family. (585 aa)
SP1Transcription factor Sp1. (746 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
FAM58ACyclin-related protein FAM58A; Belongs to the cyclin family. (231 aa)
CGNCingulin isoform A. (1295 aa)
SNW1SNW domain-containing protein 1. (536 aa)
MEIS3Homeobox protein Meis3 isoform B. (398 aa)
NEDD8NEDD8. (79 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
FBN1Uncharacterized protein. (2939 aa)
RNF111-1E3 ubiquitin-protein ligase Arkadia isoform A. (911 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (418 aa)
SKILSki-like protein. (336 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
MEIS1Homeobox protein Meis1. (470 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2 isoform A. (1616 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
F11RJunctional adhesion molecule A. (310 aa)
ITGB8-1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TGFBR2-2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
IRX5Iroquois-class homeodomain protein IRX-5. (487 aa)
IRX6-1Iroquois-class homeodomain protein IRX-6 isoform A. (504 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (246 aa)
CCNT1Cyclin-T1; Belongs to the cyclin family. (592 aa)
MEIS2Homeobox domain-containing protein. (415 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
SMAD2-2Mothers against decapentaplegic homolog. (512 aa)
SMAD7Mothers against decapentaplegic homolog. (384 aa)
SMURF1E3 ubiquitin-protein ligase. (732 aa)
SMURF2E3 ubiquitin-protein ligase. (786 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.