STRINGSTRING
PRKACB PRKACB Y1Q_0007599 Y1Q_0007599 APOA5 APOA5 APOA4 APOA4 PLG PLG SMPDL3A SMPDL3A PCSK9 PCSK9 CDCP2 CDCP2 APOA2 APOA2 NCEH1 NCEH1 SAR1B SAR1B LSR LSR PCSK5 PCSK5 Y1Q_0012629 Y1Q_0012629 PCSK1 PCSK1 LIPC LIPC PLEKHD1 PLEKHD1 NR1H3 NR1H3 RPS27A RPS27A CLHC1 CLHC1 HDLBP HDLBP ZDHHC19 ZDHHC19 LDLRAP1 LDLRAP1 MYLIP MYLIP CUBN CUBN CETP-1 CETP-1 Y1Q_0017148 Y1Q_0017148 LCAT LCAT P4HB P4HB PTCHD1 PTCHD1 AP2A2 AP2A2 Y1Q_0008175 Y1Q_0008175 LMF1 LMF1 Y1Q_0013263 Y1Q_0013263 APOE APOE AP2A2-2 AP2A2-2 Y1Q_0018253 Y1Q_0018253 LMF2 LMF2 PCSK4 PCSK4 PCSK4-2 PCSK4-2 ANGPTL4-1 ANGPTL4-1 LPL LPL Y1Q_0018187 Y1Q_0018187 A2M A2M Y1Q_0018184 Y1Q_0018184 Y1Q_0018186 Y1Q_0018186 VTG1 VTG1 Y1Q_0020858 Y1Q_0020858 NPC2 NPC2 Y1Q_0006499 Y1Q_0006499 MTTP MTTP APOC2 APOC2 SCARB1 SCARB1 ZDHHC8 ZDHHC8 KXD1 KXD1 ZDHHC5 ZDHHC5 APOF APOF SAR1A SAR1A Y1Q_0022269 Y1Q_0022269 PLTP PLTP AP2S1 AP2S1 Y1Q_0012141 Y1Q_0012141 PDIA2 PDIA2 Y1Q_0010450 Y1Q_0010450 Y1Q_0010449 Y1Q_0010449 A2ML1 A2ML1 Y1Q_0010456 Y1Q_0010456 OVST OVST Y1Q_0010451 Y1Q_0010451 Y1Q_0010454 Y1Q_0010454 Y1Q_0023041 Y1Q_0023041 Y1Q_0014723 Y1Q_0014723 Y1Q_0018248 Y1Q_0018248 Y1Q_0014721 Y1Q_0014721 AMN AMN Y1Q_0014720 Y1Q_0014720 Y1Q_0018254 Y1Q_0018254 AP2M1 AP2M1 PTCHD4 PTCHD4 Y1Q_0001141 Y1Q_0001141 AADACL4 AADACL4 Y1Q_0001147 Y1Q_0001147 APOB APOB Y1Q_0001142 Y1Q_0001142 Y1Q_0001138 Y1Q_0001138
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform C; Belongs to the protein kinase superfamily. (368 aa)
Y1Q_0007599Uncharacterized protein. (420 aa)
APOA5Apolipoprotein A-V. (395 aa)
APOA4Apolipoprotein A-IV. (323 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (802 aa)
SMPDL3AAcid sphingomyelinase-like phosphodiesterase 3a. (349 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (882 aa)
CDCP2CUB domain-containing protein 2. (516 aa)
APOA2Apolipoprotein A-II. (115 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
SAR1BGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
LSRLipolysis-stimulated lipoprotein receptor. (517 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5 isoform B; Belongs to the peptidase S8 family. (1791 aa)
Y1Q_0012629S8_pro-domain domain-containing protein. (117 aa)
PCSK1Neuroendocrine convertase 1; Belongs to the peptidase S8 family. (910 aa)
LIPCHepatic triacylglycerol lipase. (498 aa)
PLEKHD1Pleckstrin-like proteiny domain-containing family D member 1. (524 aa)
NR1H3Oxysterols receptor LXR-alpha. (408 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (587 aa)
HDLBPVigilin. (1290 aa)
ZDHHC19Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (236 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (302 aa)
MYLIPE3 ubiquitin-protein ligase MYLIP. (445 aa)
CUBNCubilin. (3619 aa)
CETP-1Cholesteryl ester transfer protein isoform B. (173 aa)
Y1Q_0017148Ovostatin-like protein 1-like. (79 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (430 aa)
P4HBProtein disulfide-isomerase. (512 aa)
PTCHD1Patched domain-containing protein 1 isoform B. (888 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
Y1Q_0008175Vitellogenin-like. (3859 aa)
LMF1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (544 aa)
Y1Q_0013263Uncharacterized protein. (95 aa)
APOEApolipoprotein E. (164 aa)
AP2A2-2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (911 aa)
Y1Q_0018253Uncharacterized protein; Belongs to the peptidase S8 family. (460 aa)
LMF2Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (594 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (578 aa)
PCSK4-2Uncharacterized protein. (188 aa)
ANGPTL4-1Angiopoietin-related protein 4 isoform B. (359 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (484 aa)
Y1Q_0018187Uncharacterized protein. (754 aa)
A2MUncharacterized protein. (1453 aa)
Y1Q_0018184Uncharacterized protein. (1461 aa)
Y1Q_0018186Alpha-2-macroglobulin-like. (536 aa)
VTG1Vitellogenin-1. (1746 aa)
Y1Q_0020858Vitellogenin-1-like. (2014 aa)
NPC2Epididymal secretory protein E1. (150 aa)
Y1Q_0006499Uncharacterized protein; Belongs to the protein kinase superfamily. (401 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (893 aa)
APOC2Apolipoprotein C-II. (221 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (803 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (745 aa)
APOFApolipoprotein F. (275 aa)
SAR1AGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
Y1Q_0022269Vitellogenin domain-containing protein. (906 aa)
PLTPPhospholipid transfer protein. (487 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
Y1Q_0012141Uncharacterized protein. (1720 aa)
PDIA2Protein disulfide-isomerase. (539 aa)
Y1Q_0010450TED_complement domain-containing protein. (204 aa)
Y1Q_0010449Alpha-2-macroglobulin-like protein 1. (266 aa)
A2ML1Uncharacterized protein. (1279 aa)
Y1Q_0010456Uncharacterized protein. (175 aa)
OVSTOvostatin isoform A. (1499 aa)
Y1Q_0010451A2M_N_2 domain-containing protein. (537 aa)
Y1Q_0010454Uncharacterized protein. (1421 aa)
Y1Q_0023041MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (350 aa)
Y1Q_0014723Prostate stem cell antigen-like. (125 aa)
Y1Q_0018248Lymphocyte antigen 6E-like. (116 aa)
Y1Q_0014721Lymphocyte antigen 6E-like. (126 aa)
AMNProtein amnionless. (481 aa)
Y1Q_0014720Lymphocyte antigen 6E-like. (128 aa)
Y1Q_0018254MG3 domain-containing protein. (89 aa)
AP2M1AP-2 complex subunit mu isoform B; Belongs to the peptidase M10A family. (835 aa)
PTCHD4Patched domain-containing protein 4. (286 aa)
Y1Q_0001141Arylacetamide deacetylase-like 4. (397 aa)
AADACL4Arylacetamide deacetylase-like 4. (570 aa)
Y1Q_0001147Arylacetamide deacetylase-like 4. (349 aa)
APOBApolipoprotein B-100. (4482 aa)
Y1Q_0001142Arylacetamide deacetylase-like 3. (403 aa)
Y1Q_0001138Arylacetamide deacetylase-like 4. (88 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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