STRINGSTRING
FRS2 FRS2 SOS1-2 SOS1-2 STIL STIL MKNK1-2 MKNK1-2 PTBP2 PTBP2 POLR2H POLR2H PIK3CB PIK3CB Y1Q_0010680 Y1Q_0010680 FGF1-1 FGF1-1 PPP2CA PPP2CA GAB1 GAB1 FGF7-2 FGF7-2 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 FNDC3A FNDC3A RPS27A RPS27A SPRED2-1 SPRED2-1 FNDC3A-2 FNDC3A-2 GTF2F2 GTF2F2 POLR2I POLR2I Y1Q_0018542 Y1Q_0018542 POLR2B POLR2B FGF5 FGF5 ESRP2-2 ESRP2-2 POLR2C POLR2C POLR2G POLR2G SPRED1 SPRED1 FGF10 FGF10 ESRP2 ESRP2 POLR2A POLR2A ANOS1 ANOS1 FGFR4 FGFR4 GRB2 GRB2 Y1Q_0006103 Y1Q_0006103 PPP2CB PPP2CB POLR2J POLR2J NCBP2 NCBP2 FGF17-1 FGF17-1 FRS3 FRS3 FGFR2 FGFR2 HNRNPM HNRNPM NCBP1 NCBP1 PTBP3 PTBP3 MKNK1 MKNK1 POLR2F POLR2F RBFOX2 RBFOX2 Y1Q_0024144 Y1Q_0024144 BRAF-2 BRAF-2 KRAS-2 KRAS-2 KRAS-1 KRAS-1 POLR2L-2 POLR2L-2 FLRT1-2 FLRT1-2 Y1Q_0011870 Y1Q_0011870 FGF16 FGF16 Y1Q_0015649 Y1Q_0015649 NPM3 NPM3 FGF18 FGF18 PTPN11 PTPN11 KXD1 KXD1 FGFR2-2 FGFR2-2 GTF2F1 GTF2F1 TIAL1-2 TIAL1-2 Y1Q_0006325 Y1Q_0006325 POLR2L-1 POLR2L-1 FGF22 FGF22 PTBP1 PTBP1 POLR2E POLR2E TIAL1 TIAL1 FGF23 FGF23 NRAS NRAS FGF6 FGF6 FGF9 FGF9 FGFRL1 FGFRL1 FGFR3 FGFR3 FLRT3 FLRT3 FGFBP2 FGFBP2 FGF20 FGF20 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FRS2Fibroblast growth factor receptor substrate 2. (510 aa)
SOS1-2Son of sevenless-like protein. (1379 aa)
STILSCL-interrupting locus protein isoform B. (923 aa)
MKNK1-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (470 aa)
PTBP2Uncharacterized protein. (537 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (161 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Y1Q_0010680Uncharacterized protein. (176 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PPP2CASerine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
GAB1GRB2-associated-binding protein 1 isoform A. (720 aa)
FGF7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1011 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
SPRED2-1Sprouty-related, EVH1 domain-containing protein 2 isoform A. (313 aa)
FNDC3A-2Uncharacterized protein. (1195 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (261 aa)
POLR2IDNA-directed RNA polymerase II subunit RPB9; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (121 aa)
Y1Q_0018542Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
ESRP2-2RRM domain-containing protein. (732 aa)
POLR2CDNA-directed RNA polymerase II subunit RPB3. (275 aa)
POLR2GDNA-directed RNA polymerase II subunit RPB7. (137 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (314 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
ESRP2Epithelial splicing regulatory protein 2. (587 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1897 aa)
ANOS1Anosmin-1. (637 aa)
FGFR4Uncharacterized protein. (518 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
Y1Q_0006103Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
POLR2JDNA-directed RNA polymerase II subunit RPB11-a. (117 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (168 aa)
FGF17-1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FRS3Fibroblast growth factor receptor substrate 3. (556 aa)
FGFR2Fibroblast growth factor receptor. (818 aa)
HNRNPMHeterogeneous nuclear ribonucleoprotein M. (697 aa)
NCBP1Nuclear cap-binding protein subunit 1. (794 aa)
PTBP3Polypyrimidine tract-binding protein 3. (521 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1. (639 aa)
POLR2FDNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
RBFOX2RNA binding fox-1-like protein 2. (247 aa)
Y1Q_0024144Uncharacterized protein. (109 aa)
BRAF-2Uncharacterized protein. (791 aa)
KRAS-2GTPase KRas. (219 aa)
KRAS-1GTPase KRas. (215 aa)
POLR2L-2DNA-directed RNA polymerases I, II, and III subunit RPABC5. (74 aa)
FLRT1-2Fibronectin type-III domain-containing protein. (655 aa)
Y1Q_0011870Pkinase_Tyr domain-containing protein. (94 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Y1Q_0015649Uncharacterized protein. (1191 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
FGFR2-2Fibroblast growth factor receptor. (783 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (627 aa)
TIAL1-2Uncharacterized protein. (399 aa)
Y1Q_0006325Uncharacterized protein. (188 aa)
POLR2L-1DNA-directed RNA polymerases I, II, and III subunit RPABC5. (104 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (141 aa)
PTBP1Uncharacterized protein. (558 aa)
POLR2EDNA-directed RNA polymerases I, II, and III subunit RPABC1. (231 aa)
TIAL1Nucleolysin TIAR. (384 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
NRASGTPase NRas. (189 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFRL1Fibroblast growth factor receptor-like 1 isoform A. (478 aa)
FGFR3Fibroblast growth factor receptor. (837 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (661 aa)
FGFBP2Fibroblast growth factor-binding protein 2. (88 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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