STRINGSTRING
TCF7L1 TCF7L1 44G24.1 44G24.1 Y1Q_0022362 Y1Q_0022362 Y1Q_0020098 Y1Q_0020098 Y1Q_0020100 Y1Q_0020100 HIST2H2BE HIST2H2BE HIST1H2BF HIST1H2BF SOX12 SOX12 WNT3 WNT3 PSMD14 PSMD14 PSMA3 PSMA3 DACT1 DACT1 RSPO3 RSPO3 PSMB4 PSMB4 PSMD4 PSMD4 CSNK1A1 CSNK1A1 TCF7 TCF7 WNT8A WNT8A HMGXB3 HMGXB3 TLE1-2 TLE1-2 TLE4 TLE4 PIP5K1B PIP5K1B TLE1 TLE1 USP8 USP8 LEO1 LEO1 PYGO1 PYGO1 HYKK HYKK RBBP5 RBBP5 SLC39A13 SLC39A13 PSMC3 PSMC3 Y1Q_0000589 Y1Q_0000589 PSMA1 PSMA1 SOX6 SOX6 PPP2R1A PPP2R1A GSK3B-2 GSK3B-2 BCL9 BCL9 Y1Q_0003135 Y1Q_0003135 SOX30 SOX30 PSMD5-1 PSMD5-1 PSMB7 PSMB7 PSME4 PSME4 RPS27A RPS27A USP34 USP34 XPO1 XPO1 DKK2 DKK2 CXXC4 CXXC4 LEF1 LEF1 CAV3 CAV3 PSMD6 PSMD6 Y1Q_0023885 Y1Q_0023885 WNT8B WNT8B BTRC BTRC PSMB8 PSMB8 PSMB9 PSMB9 SOX17 SOX17 DVL3L DVL3L TNKS TNKS CSNK2A2 CSNK2A2 PPP2R5B PPP2R5B SFRP1 SFRP1 SOX7 SOX7 RSPO2 RSPO2 FZD6 FZD6 YWHAZ YWHAZ BHMG1 BHMG1 SFRP5-2 SFRP5-2 LRTM1 LRTM1 PSMD1 PSMD1 Y1Q_0005128 Y1Q_0005128 SOX18 SOX18 WNT1 WNT1 GSK3B GSK3B TRRAP TRRAP SOX8 SOX8 PSMD12 PSMD12 AXIN2 AXIN2 SMURF2 SMURF2 DVL1 DVL1 Y1Q_0012818 Y1Q_0012818 SOX3 SOX3 SOX11 SOX11 Y1Q_0009388 Y1Q_0009388 KLHL12 KLHL12 LGR4 LGR4 MEN1 MEN1 FZD8L FZD8L PSMA5 PSMA5 Y1Q_0008688 Y1Q_0008688 PSMC5 PSMC5 WNT3-2 WNT3-2 PYGO2 PYGO2 CUL3 CUL3 SOX13 SOX13 ASH2L ASH2L SFRP5 SFRP5 TERT TERT DKK4 DKK4 SOX4 SOX4 RSPO1 RSPO1 SOX14 SOX14 RYK RYK PSMC4 PSMC4 CREBBPA CREBBPA CREBBP CREBBP RBX1 RBX1 CBY1 CBY1 SOX10 SOX10 Y1Q_0024039 Y1Q_0024039 HMGXB4 HMGXB4 SOX5 SOX5 Y1Q_0024372 Y1Q_0024372 Y1Q_0016099 Y1Q_0016099 PSMA6 PSMA6 KREMEN1 KREMEN1 ZNRF3 ZNRF3 CDC73 CDC73 PSME2 PSME2 PSME1 PSME1 FZD4 FZD4 PSMD10 PSMD10 XIAP XIAP AMER1 AMER1 PSMD7 PSMD7 PSMC2 PSMC2 ZBTB44 ZBTB44 PSMB11 PSMB11 PSMB5 PSMB5 CSNK2B CSNK2B SOX21 SOX21 PSMD9-1 PSMD9-1 SCARB1 SCARB1 HIST1H4D HIST1H4D Y1Q_0006757 Y1Q_0006757 PSMB6 PSMB6 RNF43 RNF43 KXD1 KXD1 TCF7L2 TCF7L2 CSNK2A1 CSNK2A1 LRP5 LRP5 PSMD13 PSMD13 PSMA7 PSMA7 TNKS2 TNKS2 DKK1 DKK1 AES AES Y1Q_0000267 Y1Q_0000267 Y1Q_0000264 Y1Q_0000264 Y1Q_0000266 Y1Q_0000266 TLE2 TLE2 RSPO4 RSPO4 BCL9L-1 BCL9L-1 PSMF1 PSMF1 CTNNB1 CTNNB1 PSMD3 PSMD3 PSMB3 PSMB3 AXIN1 AXIN1 LRP6-2 LRP6-2 Y1Q_0014681 Y1Q_0014681 PSMC1 PSMC1 SFRP2 SFRP2 PSMD11 PSMD11 Y1Q_0018383 Y1Q_0018383 SOST SOST FZD8 FZD8 Y1Q_0014479 Y1Q_0014479 DVL3 DVL3 PSMC6 PSMC6 Y1Q_0012805 Y1Q_0012805 SZL SZL CAV1 CAV1 WIF1 WIF1 LGR5 LGR5 APC2 APC2 PSMB2 PSMB2 APC APC PSMD8 PSMD8 SOX9 SOX9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCF7L1Transcription factor 7-like 1 isoform D. (567 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
SOX12Transcription factor SOX. (290 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (460 aa)
PSMA3Proteasome subunit alpha type. (256 aa)
DACT1Dapper-like protein 1. (722 aa)
RSPO3R-spondin-3. (240 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa)
CSNK1A1Casein kinase I isoform C; Belongs to the protein kinase superfamily. (365 aa)
TCF7Transcription factor 7 isoform A. (452 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
HMGXB3HMG domain-containing protein 3. (1422 aa)
TLE1-2Uncharacterized protein. (780 aa)
TLE4Uncharacterized protein. (980 aa)
PIP5K1BPIPK domain-containing protein. (618 aa)
TLE1Transducin-like enhancer protein 1 isoform A. (828 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform A; Belongs to the peptidase C19 family. (1133 aa)
LEO1RNA polymerase-associated protein LEO1. (653 aa)
PYGO1Uncharacterized protein. (90 aa)
HYKKProteasome endopeptidase complex. (600 aa)
RBBP5Retinoblastoma-binding protein 5 isoform B. (539 aa)
SLC39A13Zinc transporter ZIP13. (351 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
Y1Q_0000589LRRNT domain-containing protein. (686 aa)
PSMA1Proteasome subunit alpha type. (261 aa)
SOX6Transcription factor SOX-6 isoform B. (820 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform. (643 aa)
GSK3B-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
BCL9B-cell CLL/lymphoma 9 protein. (1427 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
SOX30Transcription factor SOX-30. (457 aa)
PSMD5-126S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa)
PSMB7Proteasome subunit beta. (274 aa)
PSME4Proteasome activator complex subunit 4. (1808 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
USP34Ubiquitin carboxyl-terminal hydrolase 34 isoform A; Belongs to the peptidase C19 family. (3469 aa)
XPO1Exportin-1. (1001 aa)
DKK2Dickkopf-related protein 2. (269 aa)
CXXC4CXXC-type zinc finger protein 4. (124 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform B. (391 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (348 aa)
Y1Q_0023885Crescent. (251 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BTRCF-box/WD repeat-containing protein 1A isoform B. (626 aa)
PSMB8Proteasome subunit beta. (282 aa)
PSMB9Proteasome subunit beta. (216 aa)
SOX17Sox C-terminal domain-containing protein. (232 aa)
DVL3LSegment polarity dishevelled-like protein DVL-3. (688 aa)
TNKSPoly [ADP-ribose] polymerase. (1256 aa)
CSNK2A2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (392 aa)
PPP2R5BSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (493 aa)
SFRP1Secreted frizzled-related protein 1. (304 aa)
SOX7Transcription factor SOX-7. (378 aa)
RSPO2R-spondin-2. (174 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (489 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (319 aa)
BHMG1Basic helix-loop-helix and HMG box domain-containing protein 1. (484 aa)
SFRP5-2NTR domain-containing protein. (146 aa)
LRTM1Leucine-rich repeat and transmembrane domain-containing protein 1. (345 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
Y1Q_0005128Proteasome subunit beta. (277 aa)
SOX18Transcription factor SOX-18. (392 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (413 aa)
TRRAPTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3770 aa)
SOX8Transcription factor SOX-8. (471 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (441 aa)
AXIN2Axin-2 isoform B. (836 aa)
SMURF2E3 ubiquitin-protein ligase. (786 aa)
DVL1Uncharacterized protein. (693 aa)
Y1Q_0012818Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (341 aa)
SOX3Transcription factor SOX-3 isoform A. (324 aa)
SOX11Transcription factor SOX-11. (172 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
KLHL12Kelch-like protein 12. (564 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (956 aa)
MEN1Menin. (456 aa)
FZD8LFrizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
Y1Q_0008688Putative methyltransferase. (271 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
WNT3-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
PYGO2Pygopus-like protein 2. (371 aa)
CUL3Cullin-3; Belongs to the cullin family. (768 aa)
SOX13Transcription factor SOX-13. (643 aa)
ASH2LSet1/Ash2 histone methyltransferase complex subunit ASH2. (591 aa)
SFRP5Secreted frizzled-related protein 5. (171 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (599 aa)
DKK4Dickkopf-related protein 4. (219 aa)
SOX4Transcription factor SOX. (399 aa)
RSPO1R-spondin-1. (260 aa)
SOX14Transcription factor SOX-14. (240 aa)
RYKTyrosine-protein kinase RYK. (541 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
CREBBPACREB-binding protein isoform A. (1756 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (104 aa)
CBY1Chibby-like protein 1. (155 aa)
SOX10Transcription factor SOX-10. (518 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
HMGXB4HMG domain-containing protein 4. (542 aa)
SOX5Transcription factor SOX-6. (525 aa)
Y1Q_0024372Uncharacterized protein. (270 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
KREMEN1Kremen protein 1. (501 aa)
ZNRF3E3 ubiquitin-protein ligase ZNRF3. (852 aa)
CDC73Parafibromin. (531 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
PSME1Proteasome activator complex subunit 1. (150 aa)
FZD4Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (465 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (558 aa)
AMER1APC membrane recruitment protein 1. (1161 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
ZBTB44Zinc finger and BTB domain-containing protein 44. (370 aa)
PSMB11Proteasome subunit beta. (261 aa)
PSMB5Proteasome subunit beta type-5. (211 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa)
SOX21HMG box domain-containing protein. (120 aa)
PSMD9-126S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
PSMB6Proteasome subunit beta. (227 aa)
RNF43E3 ubiquitin-protein ligase RNF43. (377 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
TCF7L2Transcription factor 7-like 2 isoform A. (411 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (435 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
TNKS2Poly [ADP-ribose] polymerase. (1141 aa)
DKK1Dickkopf-related protein 1. (103 aa)
AESAmino-terminal enhancer of split. (221 aa)
Y1Q_0000267TLE_N domain-containing protein. (241 aa)
Y1Q_0000264Transducin-like enhancer protein 2. (198 aa)
Y1Q_0000266Uncharacterized protein. (595 aa)
TLE2WD_REPEATS_REGION domain-containing protein. (436 aa)
RSPO4R-spondin-4. (239 aa)
BCL9L-1B-cell CLL/lymphoma 9-like protein isoform B. (1409 aa)
PSMF1Proteasome inhibitor PI31 subunit. (273 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (521 aa)
PSMB3Proteasome subunit beta. (205 aa)
AXIN1Uncharacterized protein. (892 aa)
LRP6-2Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (518 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
SOSTSclerostin. (214 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (242 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
DVL3Segment polarity dishevelled-like protein DVL-3 isoform B. (732 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
SZLSizzled. (286 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
WIF1Wnt inhibitory factor 1. (377 aa)
LGR5Uncharacterized protein. (579 aa)
APC2Uncharacterized protein. (2467 aa)
PSMB2Proteasome subunit beta. (201 aa)
APCAdenomatous polyposis coli protein. (2841 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (257 aa)
SOX9Transcription factor SOX-9. (495 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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