37 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (789 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	NEDD8	NEDD8. (79 aa)
	SMAD3	Mothers against decapentaplegic homolog. (426 aa)
	FBN1	Uncharacterized protein. (2939 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	LTBP2	Latent-transforming growth factor beta-binding protein 2 isoform A. (1616 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	ITGB8-1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	TGFBR2-2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
	Y1Q_0009747	Mothers against decapentaplegic homolog. (517 aa)
	SMAD2-2	Mothers against decapentaplegic homolog. (512 aa)
	SMAD7	Mothers against decapentaplegic homolog. (384 aa)
	SMURF2	E3 ubiquitin-protein ligase. (786 aa)
	Y1Q_0018253	Uncharacterized protein; Belongs to the peptidase S8 family. (460 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4. (578 aa)
	PCSK4-2	Uncharacterized protein. (188 aa)
	STUB1	E3 ubiquitin-protein ligase CHIP isoform A. (339 aa)
	ITGAV-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
	LDLRAD4	Low-density lipoprotein receptor class A domain-containing protein 4. (310 aa)
	STRAP	Serine-threonine kinase receptor-associated protein. (350 aa)
	LTBP2-2	Uncharacterized protein. (1551 aa)
	LTBP3	Uncharacterized protein. (620 aa)
	SCARB1	Scavenger receptor class B member 1 isoform A. (959 aa)
	MTMR4	Myotubularin-related protein 4 isoform A. (1123 aa)
	KXD1	KxDL motif-containing protein 1. (293 aa)
	LTBP4	Latent-transforming growth factor beta-binding protein 4. (1231 aa)
	PMEPA1-1	Protein TMEPAI isoform B. (238 aa)
	Y1Q_0002693	Uncharacterized protein. (87 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (242 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	UBE2M	NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	ITGB3-2	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
	SMAD4	Mothers against decapentaplegic homolog. (559 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAMBI	SMAD2-2	A0A151PCV5	A0A151MWR4	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.454
BAMBI	SMAD3	A0A151PCV5	A0A151M8V6	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.454
BAMBI	SMAD4	A0A151PCV5	A0A151PJG8	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.515
BAMBI	SMAD7	A0A151PCV5	A0A151MWS7	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.821
BAMBI	TGFB1	A0A151PCV5	A0A151P039	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	TGF_BETA_2 domain-containing protein.	0.699
BAMBI	TGFBR1	A0A151PCV5	A0A151PHS2	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.981
BAMBI	TGFBR2	A0A151PCV5	A0A151M0Y8	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.666
BAMBI	TGFBR2-2	A0A151PCV5	A0A151MQZ6	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.716
BAMBI	Y1Q_0009747	A0A151PCV5	A0A151MWM4	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.515
FBN1	ITGAV-2	A0A151M9R0	A0A151NA84	Uncharacterized protein.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.551
FBN1	ITGB3	A0A151M9R0	A0A151M0A8	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.575
FBN1	ITGB3-2	A0A151M9R0	A0A151PBV2	Uncharacterized protein.	Integrin beta; Belongs to the integrin beta chain family.	0.575
FBN1	PCSK4	A0A151M9R0	A0A151N6X1	Uncharacterized protein.	Proprotein convertase subtilisin/kexin type 4.	0.566
FBN1	PCSK4-2	A0A151M9R0	A0A151N717	Uncharacterized protein.	Uncharacterized protein.	0.566
FBN1	TGFB1	A0A151M9R0	A0A151P039	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.666
FBN1	TGFB2	A0A151M9R0	A0A151P3E4	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.511
FBN1	TGFB3	A0A151M9R0	A0A151MLF6	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.425
FBN1	TGFBR1	A0A151M9R0	A0A151PHS2	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.607
FBN1	TGFBR2-2	A0A151M9R0	A0A151MQZ6	Uncharacterized protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.591
FBN1	Y1Q_0018253	A0A151M9R0	A0A151N609	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase S8 family.	0.566