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ANAPC7 ANAPC7 ANAPC5 ANAPC5 SCARB1 SCARB1 Y1Q_0018642 Y1Q_0018642 HIST1H4D HIST1H4D Y1Q_0006757 Y1Q_0006757 Y1Q_0020451 Y1Q_0020451 CDKN2D CDKN2D KXD1 KXD1 Y1Q_0013324 Y1Q_0013324 MINK1 MINK1 CDC16 CDC16 MAP4K4-2 MAP4K4-2 CEBPB CEBPB ANAPC16 ANAPC16 Y1Q_0008896 Y1Q_0008896 Y1Q_0017854 Y1Q_0017854 MRE11A MRE11A Y1Q_0020094 Y1Q_0020094 HIST1H1T HIST1H1T HIST1H2BF HIST1H2BF ANAPC1 ANAPC1 RPS6KA2 RPS6KA2 MAP2K7 MAP2K7 ASF1A ASF1A MAP3K5 MAP3K5 CDKN2C CDKN2C BARHL2 BARHL2 CDK4 CDK4 RAD50 RAD50 MAPK9 MAPK9 MAPKAPK3 MAPKAPK3 MDM4 MDM4 CDKN1C CDKN1C Y1Q_0003135 Y1Q_0003135 ETS2 ETS2 MAPKAPK3-2 MAPKAPK3-2 ANAPC2 ANAPC2 44G24.1 44G24.1 Y1Q_0022362 Y1Q_0022362 Y1Q_0020098 Y1Q_0020098 HIST1H110 HIST1H110 Y1Q_0020100 Y1Q_0020100 HIST2H2BE HIST2H2BE CDC26 CDC26 EHMT2 EHMT2 BARHL1 BARHL1 UBE2S UBE2S MAP4K4 MAP4K4 RPS27A RPS27A CDC23 CDC23 RNF2 RNF2 CDK2 CDK2 MAPK8 MAPK8 FOS FOS TLX1-1 TLX1-1 RBBP4-2 RBBP4-2 TM7SF3 TM7SF3 Y1Q_0013899 Y1Q_0013899 CCNA1-1 CCNA1-1 CDK6 CDK6 Y1Q_0020533 Y1Q_0020533 TP53 TP53 CCNE2-1 CCNE2-1 ANAPC10 ANAPC10 BARX1 BARX1 PHC2L PHC2L SCML2 SCML2 RBBP4 RBBP4 ERF ERF MAP2K3 MAP2K3 NPTX2 NPTX2 MAP2K6 MAP2K6 SUZ12 SUZ12 CDK3 CDK3 KDM6B-2 KDM6B-2 CABIN1 CABIN1 CCNE1 CCNE1 UBN2A UBN2A RING1 RING1 Y1Q_0009388 Y1Q_0009388 CDKN1A CDKN1A MAPK14 MAPK14 c-jun c-jun ANAPC15 ANAPC15 PHC2 PHC2 EHMT1 EHMT1 JUND JUND SCMH1 SCMH1 MAPK7 MAPK7 UBE2C UBE2C HMGA2 HMGA2 MAPK11 MAPK11 DBX2 DBX2 CCNA2 CCNA2 Y1Q_0012805 Y1Q_0012805 Y1Q_0014479 Y1Q_0014479 Y1Q_0018383 Y1Q_0018383 CDC27 CDC27 EZH1 EZH1 ANAPC4 ANAPC4 NKX1-1 NKX1-1 Y1Q_0009655 Y1Q_0009655 Y1Q_0014681 Y1Q_0014681 MAP2K4 MAP2K4 ATM ATM Y1Q_0006871 Y1Q_0006871 CDKN1D CDKN1D CDKN1B CDKN1B PHC1 PHC1 Y1Q_0010995 Y1Q_0010995 SRCAP SRCAP GLTSCR1-1 GLTSCR1-1 FOSL2 FOSL2 HLX-1 HLX-1 NME8 NME8 EZH2 EZH2 MAP3K15 MAP3K15 PHC3 PHC3 TXN TXN BARX2 BARX2 ETS1 ETS1 FZR1 FZR1 CBX7-1 CBX7-1 CBX6 CBX6 H1F0 H1F0 NPTXR NPTXR Y1Q_0016099 Y1Q_0016099 ACD ACD ETV3 ETV3 Y1Q_0012277 Y1Q_0012277 ETV3L ETV3L EED EED H2AFZ H2AFZ Y1Q_0019536 Y1Q_0019536 Y1Q_0015487 Y1Q_0015487 Y1Q_0015488 Y1Q_0015488 HIST1H2B5L HIST1H2B5L H2AFV H2AFV CBX8 CBX8 CBX4 CBX4 ANAPC11 ANAPC11 MAPK1 MAPK1 HIRA HIRA EP400 EP400 Y1Q_0018641 Y1Q_0018641 MAPKAPK5 MAPKAPK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANAPC7Anaphase-promoting complex subunit 7. (608 aa)
ANAPC5Anaphase-promoting complex subunit 5. (756 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
Y1Q_0018642Uncharacterized protein. (841 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
Y1Q_0020451Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (167 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
Y1Q_0013324Uncharacterized protein. (146 aa)
MINK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
CDC16Cell division cycle 16-like protein. (622 aa)
MAP4K4-2Uncharacterized protein. (1413 aa)
CEBPBCCAAT/enhancer-binding protein beta. (141 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
Y1Q_0008896Uncharacterized protein. (867 aa)
Y1Q_0017854ETS domain-containing transcription factor ERF-like. (190 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
Y1Q_0020094Histone H1.01-like. (168 aa)
HIST1H1THistone H1t. (203 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1942 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform C. (488 aa)
ASF1AHistone chaperone ASF1A. (204 aa)
MAP3K5Protein kinase domain-containing protein. (1314 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (170 aa)
BARHL2BarH-like 2 homeobox protein. (294 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RAD50DNA repair protein RAD50. (1448 aa)
MAPK9Mitogen-activated protein kinase. (430 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (354 aa)
MDM4Protein Mdm4. (513 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (223 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
ETS2Protein C-ets-2. (490 aa)
MAPKAPK3-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (387 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (675 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
HIST1H110Histone H1.10. (124 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
CDC26Anaphase-promoting complex subunit CDC26. (84 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform A. (1311 aa)
BARHL1BarH-like 1 homeobox protein. (228 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (215 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4 isoform A. (1285 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
CDC23Cell division cycle 23-like protein isoform B. (585 aa)
RNF2E3 ubiquitin-protein ligase RING2 isoform B. (404 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOSProto-oncogene c-Fos isoform A. (530 aa)
TLX1-1T-cell leukemia homeobox protein 1 isoform A. (304 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
TM7SF3Transmembrane 7 superfamily member 3. (581 aa)
Y1Q_0013899Uncharacterized protein. (103 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
Y1Q_0020533CNH domain-containing protein. (688 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
CCNE2-1G1/S-specific cyclin-E2 isoform B; Belongs to the cyclin family. (410 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (179 aa)
BARX1Homeobox protein BarH-like 1. (247 aa)
PHC2LPolyhomeotic-like protein 2 isoform B. (525 aa)
SCML2SAM domain-containing protein. (805 aa)
RBBP4Histone-binding protein RBBP4. (424 aa)
ERFETS domain-containing transcription factor ERF. (482 aa)
MAP2K3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
NPTX2Neuronal pentraxin-2. (347 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (348 aa)
SUZ12Polycomb protein SUZ12. (667 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
KDM6B-2Uncharacterized protein. (1393 aa)
CABIN1Calcineurin-binding protein cabin-1 isoform D. (2219 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (408 aa)
UBN2AUbinuclein 2a isoform A. (1010 aa)
RING1E3 ubiquitin-protein ligase RING1. (327 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (232 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
ANAPC15Anaphase-promoting complex subunit 15. (94 aa)
PHC2Polyhomeotic-like protein 2 isoform A. (324 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1. (931 aa)
JUNDBZIP domain-containing protein. (87 aa)
SCMH1Polycomb protein SCMH1 isoform A. (709 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (675 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
HMGA2High mobility group protein HMGI-C. (112 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
DBX2Homeobox protein DBX2. (216 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
CDC27Cell division cycle 27-like protein. (834 aa)
EZH1Uncharacterized protein. (751 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (796 aa)
NKX1-1Homeobox protein SAX-1. (386 aa)
Y1Q_0009655Homeobox domain-containing protein. (138 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform A; Belongs to the protein kinase superfamily. (394 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
Y1Q_0006871Mitogen-activated protein kinase kinase kinase 6-like. (220 aa)
CDKN1DCyclin-dependent kinase inhibitor 1D. (153 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (131 aa)
PHC1Polyhomeotic-like protein 1 isoform A. (688 aa)
Y1Q_0010995Neuronal pentraxin-1-like. (527 aa)
SRCAPHelicase SRCAP. (1772 aa)
GLTSCR1-1Glioma tumor suppressor candidate region 1 protein isoform C. (1814 aa)
FOSL2Fos-related antigen 2. (253 aa)
HLX-1H2.0-like homeobox protein isoform A. (362 aa)
NME8Thioredoxin domain-containing protein 3 isoform B. (615 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform A. (806 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15 isoform C. (1056 aa)
PHC3Polyhomeotic-like protein 3. (581 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
BARX2Homeobox protein BarH-like 2. (273 aa)
ETS1Protein C-ets-1 isoform B. (540 aa)
FZR1Fizzy-related protein-like protein. (493 aa)
CBX7-1Chromobox protein-like protein 7 isoform B. (252 aa)
CBX6Chromobox protein-like protein 6 isoform A. (427 aa)
H1F0Histone H5. (187 aa)
NPTXRNeuronal pentraxin receptor. (502 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
ACDAdrenocortical dysplasia protein-like protein. (482 aa)
ETV3ETS translocation variant 3. (612 aa)
Y1Q_0012277Mitogen-activated protein kinase kinase kinase kinase 4-like. (118 aa)
ETV3LETS translocation variant 3-like protein. (417 aa)
EEDPolycomb protein EED. (427 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
Y1Q_0019536Mitogen-activated protein kinase. (505 aa)
Y1Q_0015487Uncharacterized protein. (122 aa)
Y1Q_0015488Protein kinase domain-containing protein. (586 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AFVHistone H2A; Belongs to the histone H2A family. (128 aa)
CBX8Chromobox protein-like protein 8. (366 aa)
CBX4E3 SUMO-protein ligase CBX4. (456 aa)
ANAPC11Anaphase-promoting complex subunit 11. (98 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1022 aa)
EP400E1A-binding protein p400 isoform A. (3038 aa)
Y1Q_0018641Myb-like domain-containing protein. (783 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform B. (510 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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