STRINGSTRING
GNG8 GNG8 GNB4 GNB4 PSMD4 PSMD4 PSMB4 PSMB4 WNT11 WNT11 GNG4 GNG4 DAAM1 DAAM1 PSMA3 PSMA3 PSMD14 PSMD14 Y1Q_0011504 Y1Q_0011504 GNG3 GNG3 PDE6H PDE6H TCF7L1 TCF7L1 ROR1L ROR1L HYKK HYKK PSMC3 PSMC3 PSMA1 PSMA1 Y1Q_0002897 Y1Q_0002897 GNB3 GNB3 PSMD5-1 PSMD5-1 PSMB7 PSMB7 PSME4 PSME4 RPS27A RPS27A WDR92 WDR92 TCF7 TCF7 PSMD8 PSMD8 PSMB2 PSMB2 PRICKLE1 PRICKLE1 AP2M1 AP2M1 PSMC6 PSMC6 DVL3 DVL3 FZD8 FZD8 PSMD11 PSMD11 FZD2 FZD2 FHDC1 FHDC1 PSMC1 PSMC1 Y1Q_0023041 Y1Q_0023041 PRKCG PRKCG PSMB3 PSMB3 PSMD3 PSMD3 AP2S1 AP2S1 DAAM2 DAAM2 CTNNB1 CTNNB1 PSMF1 PSMF1 Y1Q_0002376 Y1Q_0002376 PLCB1 PLCB1 PPP3R1 PPP3R1 Y1Q_0011868 Y1Q_0011868 LEF1 LEF1 PSMD6 PSMD6 Y1Q_0023853 Y1Q_0023853 PSMB8 PSMB8 PSMB9 PSMB9 DVL3L DVL3L FZD1 FZD1 Y1Q_0020180 Y1Q_0020180 MAP3K7 MAP3K7 PLCB2 PLCB2 FZD6 FZD6 WNT5B WNT5B PSMD1 PSMD1 CLTB-1 CLTB-1 Y1Q_0005128 Y1Q_0005128 WNT4 WNT4 WNT1 WNT1 AP2A2 AP2A2 RAC1 RAC1 SMURF1 SMURF1 GNG13 GNG13 Y1Q_0016359 Y1Q_0016359 PRKCA PRKCA PSMD12 PSMD12 SMURF2 SMURF2 GNG2 GNG2 AP2A2-2 AP2A2-2 DVL1 DVL1 NLK NLK FZD8L FZD8L FZD7 FZD7 PSMA5 PSMA5 PSMC5 PSMC5 PRICKLE4 PRICKLE4 CLTA CLTA PDE6B-2 PDE6B-2 PRICKLE3 PRICKLE3 NFATC1 NFATC1 PSMC4 PSMC4 RAC2 RAC2 WNT5B-2 WNT5B-2 GNG12 GNG12 ROR1 ROR1 PARD6A PARD6A PDE6G PDE6G PSMA6 PSMA6 PSME2 PSME2 PSME1 PSME1 FZD4 FZD4 PSMD10 PSMD10 WNT11B WNT11B NFAT5 NFAT5 PSMD7 PSMD7 PSMC2 PSMC2 PSMB11 PSMB11 PSMB5 PSMB5 PSMD9-1 PSMD9-1 SCARB1 SCARB1 PSMB6 PSMB6 TCF7L2 TCF7L2 PRKCB PRKCB PLCB3 PLCB3 PSMD13 PSMD13 Y1Q_0002713 Y1Q_0002713 PSMA7 PSMA7 PDE6B PDE6B Y1Q_0001982 Y1Q_0001982 FZD3 FZD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (155 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
DAAM1Uncharacterized protein. (1070 aa)
PSMA3Proteasome subunit alpha type. (256 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (460 aa)
Y1Q_0011504Uncharacterized protein. (742 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (114 aa)
PDE6HRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (85 aa)
TCF7L1Transcription factor 7-like 1 isoform D. (567 aa)
ROR1LInactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
HYKKProteasome endopeptidase complex. (600 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
PSMA1Proteasome subunit alpha type. (261 aa)
Y1Q_0002897Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
GNB3WD_REPEATS_REGION domain-containing protein. (340 aa)
PSMD5-126S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa)
PSMB7Proteasome subunit beta. (274 aa)
PSME4Proteasome activator complex subunit 4. (1808 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
WDR92WD repeat-containing protein 92. (577 aa)
TCF7Transcription factor 7 isoform A. (452 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (257 aa)
PSMB2Proteasome subunit beta. (201 aa)
PRICKLE1Prickle-like protein 1 isoform A. (912 aa)
AP2M1AP-2 complex subunit mu isoform B; Belongs to the peptidase M10A family. (835 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
DVL3Segment polarity dishevelled-like protein DVL-3 isoform B. (732 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (242 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (518 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
FHDC1FH2 domain-containing protein 1. (1134 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
Y1Q_0023041MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (350 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (633 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (521 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
DAAM2Disheveled-associated activator of morphogenesis 2 isoform A. (1113 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
PSMF1Proteasome inhibitor PI31 subunit. (273 aa)
Y1Q_00023761-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like. (108 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1146 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
Y1Q_0011868Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform B. (391 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (348 aa)
Y1Q_0023853Uncharacterized protein. (811 aa)
PSMB8Proteasome subunit beta. (282 aa)
PSMB9Proteasome subunit beta. (216 aa)
DVL3LSegment polarity dishevelled-like protein DVL-3. (688 aa)
FZD1G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (335 aa)
Y1Q_0020180FH2 domain-containing protein 1-like. (455 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7 isoform A. (610 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (489 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (395 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
CLTB-1Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (220 aa)
Y1Q_0005128Proteasome subunit beta. (277 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (214 aa)
SMURF1E3 ubiquitin-protein ligase. (732 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
Y1Q_0016359Uncharacterized protein. (173 aa)
PRKCANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (441 aa)
SMURF2E3 ubiquitin-protein ligase. (786 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (228 aa)
AP2A2-2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (911 aa)
DVL1Uncharacterized protein. (693 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (524 aa)
FZD8LFrizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
FZD7G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (331 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
PRICKLE4Prickle-like protein 4 isoform A. (594 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa)
PDE6B-2Phosphodiesterase. (818 aa)
PRICKLE3Prickle-like protein 3 isoform B. (551 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform B. (929 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
RAC2Uncharacterized protein. (179 aa)
WNT5B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ROR1Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (909 aa)
PARD6APartitioning defective 6-like protein alpha. (367 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (90 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
PSME1Proteasome activator complex subunit 1. (150 aa)
FZD4Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (465 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
WNT11BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (811 aa)
NFAT5Nuclear factor of activated T-cells 5 isoform A. (858 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMB11Proteasome subunit beta. (261 aa)
PSMB5Proteasome subunit beta type-5. (211 aa)
PSMD9-126S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
PSMB6Proteasome subunit beta. (227 aa)
TCF7L2Transcription factor 7-like 2 isoform A. (411 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
PLCB3Phosphoinositide phospholipase C. (582 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
Y1Q_0002713Formin-H-like. (738 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PDE6BPhosphodiesterase. (864 aa)
Y1Q_0001982PLC-beta_C domain-containing protein. (450 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (632 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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