77 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNA12	Guanine nucleotide-binding protein subunit alpha-12 isoform A. (383 aa)
	VAV3-2	Uncharacterized protein. (846 aa)
	ARHGEF25	Rho guanine nucleotide exchange factor 25. (503 aa)
	TIAM2	Uncharacterized protein. (1768 aa)
	SOS1-2	Son of sevenless-like protein. (1379 aa)
	ARHGEF33-1	Rho guanine nucleotide exchange factor 33 isoform A. (769 aa)
	KALRN	Triple functional domain protein. (2926 aa)
	SESTD1	SEC14 domain and spectrin repeat-containing protein 1. (696 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (114 aa)
	MCF2	Proto-oncogene DBL isoform D. (1306 aa)
	ADRA1B	Uncharacterized protein. (203 aa)
	GNB4	Guanine nucleotide-binding protein subunit beta-4. (340 aa)
	ECT2	Protein ECT2 isoform A. (914 aa)
	ARHGEF37	Rho guanine nucleotide exchange factor 37. (697 aa)
	ARHGEF2	Rho guanine nucleotide exchange factor 2. (994 aa)
	AKAP13-1	A-kinase anchor protein 13 isoform B. (1730 aa)
	GNB3	WD_REPEATS_REGION domain-containing protein. (340 aa)
	TIAM1	T-lymphoma invasion and metastasis-inducing protein 1. (1471 aa)
	ITSN1-2	Uncharacterized protein. (492 aa)
	VAV2	Uncharacterized protein. (839 aa)
	Y1Q_0020621	DH domain-containing protein. (181 aa)
	Y1Q_0011868	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
	ARHGEF38	Rho guanine nucleotide exchange factor 38 isoform B. (777 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10-like protein isoform B. (1322 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19. (851 aa)
	Y1Q_0023273	Uncharacterized protein. (599 aa)
	RHOA	Transforming protein RhoA. (255 aa)
	RHOC	Rho-related GTP-binding protein RhoC. (193 aa)
	TGM3	Protein-glutamine gamma-glutamyltransferase E isoform B. (757 aa)
	TGM3-2	Protein-glutamine gamma-glutamyltransferase E-like. (694 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
	C1GALT1A	Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-A. (432 aa)
	ADRA1D	Alpha-1D adrenergic receptor. (507 aa)
	NET1	Neuroepithelial cell-transforming 1 protein isoform A. (591 aa)
	FGD3	FYVE, RhoGEF and PH domain-containing protein 3. (917 aa)
	GNG13	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
	GNA13	Guanine nucleotide-binding protein subunit alpha-13. (422 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (228 aa)
	SOS1-1	Son of sevenless-like protein 1 isoform A. (1305 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (628 aa)
	Y1Q_0006107	Rho guanine nucleotide exchange factor 7. (376 aa)
	ARHGEF6-2	Uncharacterized protein. (785 aa)
	MCF2-2	Uncharacterized protein. (1034 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1396 aa)
	FGD2	FYVE, RhoGEF and PH domain-containing protein 2. (696 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (590 aa)
	TBXA2R	Thromboxane A2 receptor. (355 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
	FGD4	Uncharacterized protein. (831 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11 isoform C. (1419 aa)
	VAV3	Guanine nucleotide exchange factor VAV3. (815 aa)
	ARHGEF10	DH domain-containing protein. (1355 aa)
	ARHGEF9	Uncharacterized protein. (840 aa)
	NET1-2	Uncharacterized protein. (556 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12 isoform A. (1601 aa)
	ARHGEF40	Rho guanine nucleotide exchange factor 40. (294 aa)
	NGEF	Ephexin-1. (569 aa)
	SPATA13	Spermatogenesis-associated protein 13. (1708 aa)
	Y1Q_0013240	Uncharacterized protein. (82 aa)
	Y1Q_0007655	Uncharacterized protein. (256 aa)
	ARHGEF6	Rho guanine nucleotide exchange factor 6 isoform B. (540 aa)
	Y1Q_0006163	betaPIX_CC domain-containing protein. (231 aa)
	MCF2L	Uncharacterized protein. (1170 aa)
	ARHGEF1A	Rho guanine nucleotide exchange factor 2 isoform B. (970 aa)
	ARHGEF28	Rho guanine nucleotide exchange factor 28 isoform B. (1520 aa)
	ARHGEF1L	Rho guanine nucleotide exchange factor 1 isoform A. (930 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (155 aa)
	ARHGEF39	Rho guanine nucleotide exchange factor 39. (342 aa)
	TRIO	Uncharacterized protein. (3024 aa)
	ADRA1A	Alpha-1A adrenergic receptor. (335 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5 isoform B. (1796 aa)
	ARHGEF11-2	Rho guanine nucleotide exchange factor 11-like. (99 aa)
	RHOB	Rho-related GTP-binding protein RhoB. (196 aa)
	ARHGEF17	Rho guanine nucleotide exchange factor 17 isoform A. (1659 aa)
	ARHGEF40L	Rho guanine nucleotide exchange factor 40 isoform A. (1025 aa)
	ECT2L	Epithelial cell-transforming sequence 2 oncogene-like isoform A. (968 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	ADRA1B	A0A151P5U0	A0A151M6I4	Alpha-1A adrenergic receptor.	Uncharacterized protein.	0.487
ADRA1A	ADRA1D	A0A151P5U0	A0A151MYJ3	Alpha-1A adrenergic receptor.	Alpha-1D adrenergic receptor.	0.938
ADRA1A	ARHGEF12	A0A151P5U0	A0A151NQB3	Alpha-1A adrenergic receptor.	Rho guanine nucleotide exchange factor 12 isoform A.	0.572
ADRA1A	GNA12	A0A151P5U0	A0A151N241	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit alpha-12 isoform A.	0.962
ADRA1A	GNA13	A0A151P5U0	A0A151N2A8	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit alpha-13.	0.637
ADRA1A	GNB3	A0A151P5U0	A0A151MCT7	Alpha-1A adrenergic receptor.	WD_REPEATS_REGION domain-containing protein.	0.662
ADRA1A	GNB4	A0A151P5U0	A0A151M6J3	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit beta-4.	0.663
ADRA1A	GNG12	A0A151P5U0	A0A151NJB1	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.495
ADRA1A	GNG13	A0A151P5U0	A0A151N235	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.623
ADRA1A	GNG2	A0A151P5U0	A0A151N3B0	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.567
ADRA1A	GNG3	A0A151P5U0	A0A151LZJ9	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.506
ADRA1A	GNG4	A0A151P5U0	A0A151M2U9	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.567
ADRA1A	GNG8	A0A151P5U0	A0A151P1V9	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.494
ADRA1A	KALRN	A0A151P5U0	A0A151M0X2	Alpha-1A adrenergic receptor.	Triple functional domain protein.	0.446
ADRA1A	TBXA2R	A0A151P5U0	A0A151NCI8	Alpha-1A adrenergic receptor.	Thromboxane A2 receptor.	0.489
ADRA1A	TRIO	A0A151P5U0	A0A151P288	Alpha-1A adrenergic receptor.	Uncharacterized protein.	0.446
ADRA1A	Y1Q_0011868	A0A151P5U0	A0A151MHW5	Alpha-1A adrenergic receptor.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.495
ADRA1B	ADRA1A	A0A151M6I4	A0A151P5U0	Uncharacterized protein.	Alpha-1A adrenergic receptor.	0.487
ADRA1B	GNA12	A0A151M6I4	A0A151N241	Uncharacterized protein.	Guanine nucleotide-binding protein subunit alpha-12 isoform A.	0.559
ADRA1B	GNA13	A0A151M6I4	A0A151N2A8	Uncharacterized protein.	Guanine nucleotide-binding protein subunit alpha-13.	0.560