58 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNA11	Guanine nucleotide-binding protein subunit alpha-11. (333 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1146 aa)
	Y1Q_0012624	Uncharacterized protein. (354 aa)
	KCNJ11-2	Uncharacterized protein. (394 aa)
	ABCC8-2	Uncharacterized protein. (1594 aa)
	Y1Q_0005453	VWA_N domain-containing protein. (152 aa)
	CACNA2D2	VWFA domain-containing protein. (833 aa)
	SLC2A2	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
	Y1Q_0002376	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like. (108 aa)
	Y1Q_0013974	Sialic acid-binding Ig-like lectin 5. (329 aa)
	KCNS3A	Potassium voltage-gated channel subfamily S member 3; Belongs to the potassium channel family. (555 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1276 aa)
	Y1Q_0006643	Ca_chan_IQ domain-containing protein. (672 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor-like 1. (562 aa)
	ADRA2C	Alpha-2C adrenergic receptor. (417 aa)
	ITPR3	Uncharacterized protein. (2667 aa)
	GLP1R	Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (438 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (155 aa)
	GNA11-2	Uncharacterized protein. (359 aa)
	GNA15	Guanine nucleotide-binding protein subunit alpha-15. (396 aa)
	KCNB2	Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (674 aa)
	Y1Q_0001982	PLC-beta_C domain-containing protein. (450 aa)
	Y1Q_0002754	Potassium voltage-gated channel subfamily B member 1-like. (206 aa)
	PLCB3	Phosphoinositide phospholipase C. (582 aa)
	ADRA2A	Alpha-2A adrenergic receptor. (435 aa)
	SNX19	Sorting nexin-19. (998 aa)
	CACNA2D1	Calcium channel, voltage-dependent, alpha 2/delta subunit 1 preproprotein isoform B. (989 aa)
	Y1Q_0023404	Uncharacterized protein. (118 aa)
	CD36	Platelet glycoprotein 4; Belongs to the CD36 family. (461 aa)
	ACSL3	Long-chain-fatty-acid--CoA ligase 3. (670 aa)
	THAP7-1	THAP domain-containing protein 8 isoform A. (758 aa)
	Y1Q_0006499	Uncharacterized protein; Belongs to the protein kinase superfamily. (401 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform C; Belongs to the protein kinase superfamily. (368 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1954 aa)
	KCNG2-2	BTB domain-containing protein; Belongs to the potassium channel family. (517 aa)
	THAP1	THAP domain-containing protein 1. (169 aa)
	ACSL3-2	AMP-binding domain-containing protein. (663 aa)
	CACNA1E	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1843 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (228 aa)
	GNG13	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
	Y1Q_0005149	Free fatty acid receptor 1-like. (285 aa)
	ADCY6	Uncharacterized protein. (1272 aa)
	RAPGEF5A	Rap guanine nucleotide exchange factor 5 isoform A. (865 aa)
	ITPR2-2	Uncharacterized protein. (2702 aa)
	Y1Q_0023796	Uncharacterized protein. (1088 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (1680 aa)
	Y1Q_0011868	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (114 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (873 aa)
	Y1Q_0011506	Rap guanine nucleotide exchange factor 4-like. (169 aa)
	DPP4	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (757 aa)
	ADCY3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1017 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
	RAPGEF3	Uncharacterized protein. (874 aa)
	GNB4	Guanine nucleotide-binding protein subunit beta-4. (340 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC8-2	KCNJ11-2	A0A151MC94	A0A151MC41	Uncharacterized protein.	Uncharacterized protein.	0.997
ABCC8-2	PRKACB	A0A151MC94	A0A151NJ28	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit beta isoform C; Belongs to the protein kinase superfamily.	0.565
ABCC8-2	RAPGEF3	A0A151MC94	A0A151M663	Uncharacterized protein.	Uncharacterized protein.	0.665
ABCC8-2	RAPGEF5	A0A151MC94	A0A151M006	Uncharacterized protein.	Rap guanine nucleotide exchange factor 5.	0.761
ABCC8-2	SLC2A2	A0A151MC94	A0A151MGD1	Uncharacterized protein.	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.425
ABCC8-2	Y1Q_0006499	A0A151MC94	A0A151NKT3	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.565
ABCC8-2	Y1Q_0011506	A0A151MC94	A0A151M009	Uncharacterized protein.	Rap guanine nucleotide exchange factor 4-like.	0.761
ACSL3	ACSL3-2	A0A151NNJ1	A0A151NBI9	Long-chain-fatty-acid--CoA ligase 3.	AMP-binding domain-containing protein.	0.651
ACSL3-2	ACSL3	A0A151NBI9	A0A151NNJ1	AMP-binding domain-containing protein.	Long-chain-fatty-acid--CoA ligase 3.	0.651
ADCY3	GNB4	A0A151M126	A0A151M6J3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-4.	0.813
ADCY3	GNG12	A0A151M126	A0A151NJB1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.802
ADCY3	GNG13	A0A151M126	A0A151N235	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.796
ADCY3	GNG2	A0A151M126	A0A151N3B0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.801
ADCY3	GNG3	A0A151M126	A0A151LZJ9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.801
ADCY3	GNG4	A0A151M126	A0A151M2U9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.801
ADCY3	GNG8	A0A151M126	A0A151P1V9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.437
ADCY3	PRKACB	A0A151M126	A0A151NJ28	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform C; Belongs to the protein kinase superfamily.	0.921
ADCY3	RAPGEF3	A0A151M126	A0A151M663	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.927
ADCY3	RAPGEF5	A0A151M126	A0A151M006	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 5.	0.918
ADCY3	Y1Q_0006499	A0A151M126	A0A151NKT3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.921