19 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
	LGR5	Uncharacterized protein. (579 aa)
	FZD8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (242 aa)
	LRP6-2	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	RSPO4	R-spondin-4. (239 aa)
	KXD1	KxDL motif-containing protein 1. (293 aa)
	RNF43	E3 ubiquitin-protein ligase RNF43. (377 aa)
	FZD4	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (465 aa)
	ZNRF3	E3 ubiquitin-protein ligase ZNRF3. (852 aa)
	RSPO1	R-spondin-1. (260 aa)
	FZD8L	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (956 aa)
	LRTM1	Leucine-rich repeat and transmembrane domain-containing protein 1. (345 aa)
	FZD6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (489 aa)
	RSPO2	R-spondin-2. (174 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	Y1Q_0000589	LRRNT domain-containing protein. (686 aa)
	USP8	Ubiquitin carboxyl-terminal hydrolase 8 isoform A; Belongs to the peptidase C19 family. (1133 aa)
	RSPO3	R-spondin-3. (240 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD4	FZD6	A0A151NM52	A0A151MXS3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.601
FZD4	LRP5	A0A151NM52	A0A151NXF3	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.982
FZD4	LRP6-2	A0A151NM52	A0A151P774	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.984
FZD4	RNF43	A0A151NM52	A0A151NTN2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	E3 ubiquitin-protein ligase RNF43.	0.962
FZD4	RPS27A	A0A151NM52	A0A151MGG2	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin-40S ribosomal protein S27a.	0.619
FZD4	USP8	A0A151NM52	A0A151M9E6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin carboxyl-terminal hydrolase 8 isoform A; Belongs to the peptidase C19 family.	0.412
FZD4	Y1Q_0000589	A0A151NM52	A0A151MBN9	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	LRRNT domain-containing protein.	0.402
FZD4	ZNRF3	A0A151NM52	A0A151NKK9	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	E3 ubiquitin-protein ligase ZNRF3.	0.949
FZD6	FZD4	A0A151MXS3	A0A151NM52	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.601
FZD6	FZD8	A0A151MXS3	A0A151PCQ3	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.540
FZD6	FZD8L	A0A151MXS3	A0A151N9D9	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	0.451
FZD6	LRP5	A0A151MXS3	A0A151NXF3	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.729
FZD6	LRP6-2	A0A151MXS3	A0A151P774	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.800
FZD6	RNF43	A0A151MXS3	A0A151NTN2	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	E3 ubiquitin-protein ligase RNF43.	0.619
FZD6	RPS27A	A0A151MXS3	A0A151MGG2	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin-40S ribosomal protein S27a.	0.631
FZD6	RSPO4	A0A151MXS3	A0A151P1G9	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	R-spondin-4.	0.470
FZD6	USP8	A0A151MXS3	A0A151M9E6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	Ubiquitin carboxyl-terminal hydrolase 8 isoform A; Belongs to the peptidase C19 family.	0.484
FZD6	ZNRF3	A0A151MXS3	A0A151NKK9	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	E3 ubiquitin-protein ligase ZNRF3.	0.723
FZD8	FZD6	A0A151PCQ3	A0A151MXS3	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.540
FZD8	LRP5	A0A151PCQ3	A0A151NXF3	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.957