STRINGSTRING
FGF1-1 FGF1-1 FRS2 FRS2 FGF2 FGF2 FGF20 FGF20 FGF9 FGF9 FGF6 FGF6 FGF23 FGF23 KXD1 KXD1 PTPN11 PTPN11 FGF18 FGF18 NPM3 NPM3 Y1Q_0015649 Y1Q_0015649 FGF16 FGF16 Y1Q_0011870 Y1Q_0011870 BRAF-2 BRAF-2 MKNK1 MKNK1 FGF17-1 FGF17-1 PPP2CB PPP2CB Y1Q_0006103 Y1Q_0006103 GRB2 GRB2 FGFR4 FGFR4 FNDC3A-2 FNDC3A-2 RPS27A RPS27A FNDC3A FNDC3A FGF19 FGF19 FGF4 FGF4 PPP2CA PPP2CA Y1Q_0010680 Y1Q_0010680 MKNK1-2 MKNK1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FRS2Fibroblast growth factor receptor substrate 2. (510 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
Y1Q_0015649Uncharacterized protein. (1191 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Y1Q_0011870Pkinase_Tyr domain-containing protein. (94 aa)
BRAF-2Uncharacterized protein. (791 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1. (639 aa)
FGF17-1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
Y1Q_0006103Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGFR4Uncharacterized protein. (518 aa)
FNDC3A-2Uncharacterized protein. (1195 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1011 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
PPP2CASerine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
Y1Q_0010680Uncharacterized protein. (176 aa)
MKNK1-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (470 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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