42 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FRS2	Fibroblast growth factor receptor substrate 2. (510 aa)
	SOS1-2	Son of sevenless-like protein. (1379 aa)
	MKNK1-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (470 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	Y1Q_0010680	Uncharacterized protein. (176 aa)
	FGF1-1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	PPP2CA	Serine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
	GAB1	GRB2-associated-binding protein 1 isoform A. (720 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A. (1011 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	SPRED2-1	Sprouty-related, EVH1 domain-containing protein 2 isoform A. (313 aa)
	FNDC3A-2	Uncharacterized protein. (1195 aa)
	Y1Q_0018542	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
	SPRED1	Sprouty-related, EVH1 domain-containing protein 1. (314 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
	ANOS1	Anosmin-1. (637 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	Y1Q_0006103	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	FGF17-1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (556 aa)
	MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1. (639 aa)
	BRAF-2	Uncharacterized protein. (791 aa)
	KRAS-2	GTPase KRas. (219 aa)
	KRAS-1	GTPase KRas. (215 aa)
	FLRT1-2	Fibronectin type-III domain-containing protein. (655 aa)
	Y1Q_0015649	Uncharacterized protein. (1191 aa)
	NPM3	Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	KXD1	KxDL motif-containing protein 1. (293 aa)
	Y1Q_0006325	Uncharacterized protein. (188 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (141 aa)
	NRAS	GTPase NRas. (189 aa)
	FGF23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGFRL1	Fibroblast growth factor receptor-like 1 isoform A. (478 aa)
	FLRT3	Leucine-rich repeat transmembrane protein FLRT3. (661 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANOS1	FGF1-1	A0A151N0M3	A0A151M6W0	Anosmin-1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.536
ANOS1	FGF10	A0A151N0M3	A0A151MWY9	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.496
ANOS1	FGF17-1	A0A151N0M3	A0A151NBG4	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.517
ANOS1	FGF2	A0A151N0M3	A0A151PED4	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.505
ANOS1	FGF22	A0A151N0M3	A0A151P0H0	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.496
ANOS1	FGF23	A0A151N0M3	A0A151P6U7	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.626
ANOS1	FGF4	A0A151N0M3	A0A151MBM7	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.619
ANOS1	FGF5	A0A151N0M3	A0A151MPU9	Anosmin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.468
ANOS1	FGFRL1	A0A151N0M3	A0A151P948	Anosmin-1.	Fibroblast growth factor receptor-like 1 isoform A.	0.608
ANOS1	NPM3	A0A151N0M3	A0A151NP53	Anosmin-1.	Nucleoplasmin-3; Belongs to the heparin-binding growth factors family.	0.801
BRAF-2	GRB2	A0A151NIB3	A0A151N2T8	Uncharacterized protein.	Growth factor receptor-bound protein 2.	0.614
BRAF-2	KRAS-1	A0A151NIB3	A0A151NK14	Uncharacterized protein.	GTPase KRas.	0.976
BRAF-2	KRAS-2	A0A151NIB3	A0A151NIW9	Uncharacterized protein.	GTPase KRas.	0.771
BRAF-2	NRAS	A0A151NIB3	A0A151PHE9	Uncharacterized protein.	GTPase NRas.	0.986
BRAF-2	PIK3CB	A0A151NIB3	A0A151M6C3	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.507
BRAF-2	PPP2CA	A0A151NIB3	A0A151M6Y2	Uncharacterized protein.	Serine/threonine-protein phosphatase; Belongs to the SKP1 family.	0.558
BRAF-2	PPP2CB	A0A151NIB3	A0A151N580	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.558
BRAF-2	PTPN11	A0A151NIB3	A0A151NSB1	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.408
BRAF-2	SOS1-2	A0A151NIB3	A0A151M1Q1	Uncharacterized protein.	Son of sevenless-like protein.	0.597
BRAF-2	Y1Q_0006103	A0A151NIB3	A0A151N4C4	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.408