38 items (Alligator mississippiensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (510 aa)
	Y1Q_0018542	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
	FGFR4	Uncharacterized protein. (518 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	NRAS	GTPase NRas. (189 aa)
	Y1Q_0006103	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	FGF17-1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (556 aa)
	MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1. (639 aa)
	BRAF-2	Uncharacterized protein. (791 aa)
	KRAS-2	GTPase KRas. (219 aa)
	KRAS-1	GTPase KRas. (215 aa)
	Y1Q_0011870	Pkinase_Tyr domain-containing protein. (94 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	Y1Q_0015649	Uncharacterized protein. (1191 aa)
	NPM3	Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	KXD1	KxDL motif-containing protein 1. (293 aa)
	Y1Q_0006325	Uncharacterized protein. (188 aa)
	FGF23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	SOS1-2	Son of sevenless-like protein. (1379 aa)
	MKNK1-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (470 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A. (1011 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	GAB1	GRB2-associated-binding protein 1 isoform A. (720 aa)
	PPP2CA	Serine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
	FGF1-1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	Y1Q_0010680	Uncharacterized protein. (176 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	FNDC3A-2	Uncharacterized protein. (1195 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF-2	GRB2	A0A151NIB3	A0A151N2T8	Uncharacterized protein.	Growth factor receptor-bound protein 2.	0.614
BRAF-2	KRAS-1	A0A151NIB3	A0A151NK14	Uncharacterized protein.	GTPase KRas.	0.976
BRAF-2	KRAS-2	A0A151NIB3	A0A151NIW9	Uncharacterized protein.	GTPase KRas.	0.771
BRAF-2	NRAS	A0A151NIB3	A0A151PHE9	Uncharacterized protein.	GTPase NRas.	0.986
BRAF-2	PIK3CB	A0A151NIB3	A0A151M6C3	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.507
BRAF-2	PPP2CA	A0A151NIB3	A0A151M6Y2	Uncharacterized protein.	Serine/threonine-protein phosphatase; Belongs to the SKP1 family.	0.558
BRAF-2	PPP2CB	A0A151NIB3	A0A151N580	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.558
BRAF-2	PTPN11	A0A151NIB3	A0A151NSB1	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.408
BRAF-2	SOS1-2	A0A151NIB3	A0A151M1Q1	Uncharacterized protein.	Son of sevenless-like protein.	0.597
BRAF-2	Y1Q_0006103	A0A151NIB3	A0A151N4C4	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.408
BRAF-2	Y1Q_0006325	A0A151NIB3	A0A151NXS6	Uncharacterized protein.	Uncharacterized protein.	0.771
BRAF-2	Y1Q_0018542	A0A151NIB3	A0A151MP29	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.507
FGF1-1	FGF17-1	A0A151M6W0	A0A151NBG4	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.707
FGF1-1	FGF18	A0A151M6W0	A0A151NRI2	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.605
FGF1-1	FGF19	A0A151M6W0	A0A151MBT6	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.512
FGF1-1	FGF23	A0A151M6W0	A0A151P6U7	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.660
FGF1-1	FGF4	A0A151M6W0	A0A151MBM7	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.599
FGF1-1	FGF6	A0A151M6W0	A0A151P725	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
FGF1-1	FGFR4	A0A151M6W0	A0A151N2P5	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Uncharacterized protein.	0.960
FGF1-1	FRS2	A0A151M6W0	A0A151PF84	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 2.	0.568