STRINGSTRING
ATM ATM RPA1 RPA1 POLD1-2 POLD1-2 RFC4 RFC4 RAD50 RAD50 RMI1 RMI1 Y1Q_0000419 Y1Q_0000419 RAD51B RAD51B EXD2 EXD2 POLE3 POLE3 RPS27A RPS27A EXO1 EXO1 RCBTB1 RCBTB1 POLH POLH RCBTB1-2 RCBTB1-2 TDRD3 TDRD3 SPIDR SPIDR BRCA2 BRCA2 RFC3 RFC3 RPA3 RPA3 MUS81L MUS81L BLM BLM POLD4 POLD4 RAD51 RAD51 SLX1A SLX1A RMI2 RMI2 TOP3A TOP3A MEIOB MEIOB EME1 EME1 RFC5 RFC5 RFC2 RFC2 WRN WRN RAD51C RAD51C EME2 EME2 RAD51D RAD51D MUS81 MUS81 Y1Q_0008724 Y1Q_0008724 BARD1 BARD1 ANKRD12 ANKRD12 CHEK1 CHEK1 SLX4 SLX4 Y1Q_0000842 Y1Q_0000842 POLE POLE RECQL4 RECQL4 SCARB1 SCARB1 KXD1 KXD1 POLD2 POLD2 DNA2 DNA2 Y1Q_0006787 Y1Q_0006787 MRE11A MRE11A Y1Q_0007595 Y1Q_0007595 ANKRD11 ANKRD11 PCNA PCNA RAD51AP1 RAD51AP1 XRCC3 XRCC3 RFC1 RFC1 BRCA1 BRCA1 XRCC2 XRCC2 POLE2 POLE2 RBBP8-1 RBBP8-1 POLK POLK ANKRD31-1 ANKRD31-1 GEN1 GEN1 POLD3-1 POLD3-1 POLD1 POLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATMNon-specific serine/threonine protein kinase. (3063 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
POLD1-2DNA polymerase delta catalytic subunit. (392 aa)
RFC4Replication factor C subunit 4. (364 aa)
RAD50DNA repair protein RAD50. (1448 aa)
RMI1RecQ-mediated genome instability protein 1. (524 aa)
Y1Q_0000419Uncharacterized protein. (78 aa)
RAD51BDNA repair RAD51-like protein 2. (278 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2 isoform A. (621 aa)
POLE3DNA polymerase epsilon subunit 3. (143 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
EXO1Exonuclease 1. (775 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (566 aa)
POLHDNA polymerase eta. (707 aa)
RCBTB1-2BTB domain-containing protein. (595 aa)
TDRD3Tudor domain-containing protein 3 isoform A. (743 aa)
SPIDRDNA repair-scaffolding protein isoform A. (971 aa)
BRCA2Breast cancer type 2 susceptibility protein isoform A. (1174 aa)
RFC3Replication factor C subunit 3. (356 aa)
RPA3Replication protein A subunit. (120 aa)
MUS81LCrossover junction endonuclease MUS81. (156 aa)
BLMBloom syndrome protein. (1213 aa)
POLD4DNA polymerase delta subunit 4 isoform A. (206 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (393 aa)
SLX1AStructure-specific endonuclease subunit SLX1. (221 aa)
RMI2RecQ-mediated genome instability protein 2. (75 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
EME1Crossover junction endonuclease EME1. (282 aa)
RFC5Replication factor C subunit 5. (336 aa)
RFC2Replication factor C subunit 2. (340 aa)
WRNWerner syndrome ATP-dependent helicase. (1443 aa)
RAD51CDNA repair RAD51-like protein 3. (367 aa)
EME2Putative crossover junction endonuclease EME2. (451 aa)
RAD51DDNA repair RAD51-like protein 4 isoform A. (415 aa)
MUS81Crossover junction endonuclease MUS81. (271 aa)
Y1Q_0008724Uncharacterized protein. (128 aa)
BARD1BRCA1-associated RING domain protein 1 isoform B. (792 aa)
ANKRD12Ankyrin repeat domain-containing protein 12. (761 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
SLX4Structure-specific endonuclease subunit SLX4 isoform C. (1726 aa)
Y1Q_0000842DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
RECQL4ATP-dependent DNA helicase Q4 isoform A. (1385 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
POLD2DNA polymerase delta subunit 2. (501 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa)
Y1Q_0006787DNA polymerase delta catalytic subunit-like. (198 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
Y1Q_0007595DNA_pol_B_exo1 domain-containing protein. (86 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2899 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
RAD51AP1RAD51-associated protein 1. (315 aa)
XRCC3DNA repair protein XRCC3. (388 aa)
RFC1Replication factor C subunit 1. (1130 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
XRCC2DNA repair protein XRCC2. (103 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
RBBP8-1DNA endonuclease RBBP8 isoform B. (936 aa)
POLKDNA polymerase kappa isoform A. (651 aa)
ANKRD31-1Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa)
GEN1Flap endonuclease GEN-like protein 1. (480 aa)
POLD3-1DNA polymerase delta subunit 3 isoform A. (466 aa)
POLD1DNA polymerase. (439 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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