STRINGSTRING
44G24.1 44G24.1 Y1Q_0022362 Y1Q_0022362 Y1Q_0020098 Y1Q_0020098 Y1Q_0020100 Y1Q_0020100 HIST2H2BE HIST2H2BE HIST1H2BF HIST1H2BF Y1Q_0011504 Y1Q_0011504 IFIH1 IFIH1 PSMD14 PSMD14 STAM STAM PSMA3 PSMA3 Y1Q_0000060 Y1Q_0000060 TOMM20 TOMM20 OTUB1 OTUB1 NRD1 NRD1 Y1Q_0003517 Y1Q_0003517 USP24 USP24 USP21 USP21 PSMB4 PSMB4 PSMD4 PSMD4 RNF167 RNF167 USP5 USP5 MAT2B MAT2B VDAC1 VDAC1 SMAD3 SMAD3 USP8 USP8 USP50 USP50 HYKK HYKK USP3 USP3 MDM4 MDM4 PSMC3 PSMC3 DDB2 DDB2 TRAF6 TRAF6 USP47 USP47 PSMA1 PSMA1 USP5-2 USP5-2 TOMM70A TOMM70A USP25-2 USP25-2 USP16 USP16 UBLCP1 UBLCP1 USP20 USP20 PSMD5-1 PSMD5-1 PSMB7 PSMB7 GPR21 GPR21 PSME4 PSME4 RPS27A RPS27A USP34 USP34 MUL1 MUL1 SNX3 SNX3 RUVBL1 RUVBL1 PSMD6 PSMD6 ATXN7 ATXN7 Y1Q_0020784 Y1Q_0020784 USP36 USP36 PSMB8 PSMB8 PSMB9 PSMB9 CCNA1-1 CCNA1-1 TNKS TNKS IKBKG IKBKG CYLD CYLD USP46 USP46 VDAC2 VDAC2 RNF123 RNF123 WDR76 WDR76 USP48 USP48 MAP3K7 MAP3K7 KLHL18 KLHL18 ZFYVE19 ZFYVE19 ZFYVE1 ZFYVE1 TP53 TP53 HGS HGS Y1Q_0009747 Y1Q_0009747 SMAD2-2 SMAD2-2 SMAD7 SMAD7 SKP2 SKP2 CDC20B-1 CDC20B-1 TAF10 TAF10 ARRB2 ARRB2 PSMD1 PSMD1 Y1Q_0005128 Y1Q_0005128 USP7 USP7 CCP110 CCP110 USP42 USP42 TRRAP TRRAP USP22 USP22 PSMD12 PSMD12 AXIN2 AXIN2 SMURF2 SMURF2 KLHL17 KLHL17 MTFP1 MTFP1 SUDS3 SUDS3 USP32 USP32 RNF128 RNF128 ATXN7L2 ATXN7L2 USP37 USP37 Y1Q_0008616 Y1Q_0008616 PSMA5 PSMA5 PSMC5 PSMC5 Y1Q_0013741 Y1Q_0013741 USP44 USP44 RNF13 RNF13 POLB POLB VDAC3 VDAC3 DDX58 DDX58 USP14 USP14 RIPK1 RIPK1 Y1Q_0014624 Y1Q_0014624 USP19 USP19 RCE1 RCE1 PSMC4 PSMC4 USP44-2 USP44-2 TAB1 TAB1 USP18 USP18 Y1Q_0016099 Y1Q_0016099 USP33 USP33 KEAP1 KEAP1 PSMA6 PSMA6 NFKBIA NFKBIA Y1Q_0008958 Y1Q_0008958 Y1Q_0017259 Y1Q_0017259 ARR3 ARR3 PSME2 PSME2 PSME1 PSME1 USP10 USP10 PSMD10 PSMD10 Y1Q_0015578 Y1Q_0015578 AR AR ARR3-2 ARR3-2 HIST1H2B5L HIST1H2B5L PSMD7 PSMD7 ATXN7L1 ATXN7L1 GATA3 GATA3 PSMC2 PSMC2 PSMB11 PSMB11 PSMB5 PSMB5 USP9X USP9X Y1Q_0002396 Y1Q_0002396 UFD1L UFD1L USP30 USP30 PSMD9-1 PSMD9-1 SCARB1 SCARB1 PSMB6 PSMB6 Y1Q_0013191 Y1Q_0013191 KXD1 KXD1 Y1Q_0016604 Y1Q_0016604 FKBP8 FKBP8 Y1Q_0013189 Y1Q_0013189 FOXO4 FOXO4 UBFD1 UBFD1 PSMD13 PSMD13 BIRC7-1 BIRC7-1 NPEPL1 NPEPL1 PSMA7 PSMA7 TNKS2 TNKS2 ADRM1 ADRM1 Y1Q_0000243 Y1Q_0000243 USP25 USP25 ZNRF4 ZNRF4 ZNRF4-2 ZNRF4-2 IDE IDE PSMF1 PSMF1 USP2 USP2 PSMD3 PSMD3 PSMB3 PSMB3 DMWD DMWD CDC20 CDC20 AXIN1 AXIN1 BIRC2 BIRC2 MYC MYC CYLDL CYLDL WDR20 WDR20 PSMC1 PSMC1 TADA2B TADA2B LAP3 LAP3 USP46-2 USP46-2 BECN1 BECN1 SMAD1 SMAD1 PSMD11 PSMD11 Y1Q_0018383 Y1Q_0018383 WDR48 WDR48 PSMC6 PSMC6 Y1Q_0012805 Y1Q_0012805 CFTR CFTR CCNA2 CCNA2 USP15 USP15 MDM2 MDM2 PSMB2 PSMB2 CLSPN CLSPN Y1Q_0010619 Y1Q_0010619 Y1Q_0004030 Y1Q_0004030 TGFBR1 TGFBR1 NAIP NAIP SMAD4 SMAD4 PSMD8 PSMD8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0011504Uncharacterized protein. (742 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (986 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (460 aa)
STAMSignal transducing adapter molecule 1 isoform C. (582 aa)
PSMA3Proteasome subunit alpha type. (256 aa)
Y1Q_0000060Peptidylprolyl isomerase. (169 aa)
TOMM20Mitochondrial import receptor subunit TOM20-like protein. (146 aa)
OTUB1Ubiquitin thioesterase. (268 aa)
NRD1Nardilysin; Belongs to the peptidase M16 family. (1110 aa)
Y1Q_0003517Uncharacterized protein; Belongs to the peptidase M16 family. (1073 aa)
USP24Uncharacterized protein; Belongs to the peptidase C19 family. (2600 aa)
USP21Ubiquitin carboxyl-terminal hydrolase. (458 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa)
RNF167E3 ubiquitin-protein ligase RNF167. (294 aa)
USP5Ubiquitin carboxyl-terminal hydrolase. (875 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (355 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (581 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform A; Belongs to the peptidase C19 family. (1133 aa)
USP50Ubiquitin carboxyl-terminal hydrolase. (396 aa)
HYKKProteasome endopeptidase complex. (600 aa)
USP3Ubiquitin carboxyl-terminal hydrolase. (520 aa)
MDM4Protein Mdm4. (513 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
DDB2DNA damage-binding protein 2. (517 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (576 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform A; Belongs to the peptidase C19 family. (1356 aa)
PSMA1Proteasome subunit alpha type. (261 aa)
USP5-2Ubiquitin carboxyl-terminal hydrolase. (831 aa)
TOMM70AMitochondrial import receptor subunit TOM70. (501 aa)
USP25-2USP domain-containing protein; Belongs to the peptidase C19 family. (1221 aa)
USP16Ubiquitin carboxyl-terminal hydrolase. (788 aa)
UBLCP1Ubiquitin-like domain-containing CTD phosphatase 1. (342 aa)
USP20Ubiquitin carboxyl-terminal hydrolase. (952 aa)
PSMD5-126S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa)
PSMB7Proteasome subunit beta. (274 aa)
GPR21Putative G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
PSME4Proteasome activator complex subunit 4. (1808 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
USP34Ubiquitin carboxyl-terminal hydrolase 34 isoform A; Belongs to the peptidase C19 family. (3469 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (355 aa)
SNX3Sorting nexin-3. (162 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (348 aa)
ATXN7Ataxin-7. (526 aa)
Y1Q_0020784Ubiquitin carboxyl-terminal hydrolase 2-like. (253 aa)
USP36Ubiquitin carboxyl-terminal hydrolase 36. (586 aa)
PSMB8Proteasome subunit beta. (282 aa)
PSMB9Proteasome subunit beta. (216 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
TNKSPoly [ADP-ribose] polymerase. (1256 aa)
IKBKGNF-kappa-B essential modulator. (542 aa)
CYLDUncharacterized protein. (949 aa)
USP46Ubiquitin carboxyl-terminal hydrolase. (396 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (303 aa)
RNF123E3 ubiquitin-protein ligase RNF123. (1308 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (486 aa)
USP48Ubiquitin carboxyl-terminal hydrolase 48; Belongs to the peptidase C19 family. (1036 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7 isoform A. (610 aa)
KLHL18Kelch-like protein 18. (578 aa)
ZFYVE19Abscission/NoCut checkpoint regulator. (429 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1. (697 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate isoform B. (853 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
SMAD2-2Mothers against decapentaplegic homolog. (512 aa)
SMAD7Mothers against decapentaplegic homolog. (384 aa)
SKP2S-phase kinase-associated protein 2. (419 aa)
CDC20B-1Cell division cycle 20-like protein B isoform A. (555 aa)
TAF10Transcription initiation factor TFIID subunit 10. (121 aa)
ARRB2Arrestin_C domain-containing protein. (407 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
Y1Q_0005128Proteasome subunit beta. (277 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1080 aa)
CCP110Centriolar coiled-coil protein of isoform A. (1084 aa)
USP42Ubiquitin carboxyl-terminal hydrolase. (839 aa)
TRRAPTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3770 aa)
USP22Ubiquitin carboxyl-terminal hydrolase. (525 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (441 aa)
AXIN2Axin-2 isoform B. (836 aa)
SMURF2E3 ubiquitin-protein ligase. (786 aa)
KLHL17BTB domain-containing protein. (590 aa)
MTFP1Mitochondrial fission process protein 1. (167 aa)
SUDS3Sin3 histone deacetylase corepressor complex component SDS3. (336 aa)
USP32Ubiquitin carboxyl-terminal hydrolase 32 isoform D; Belongs to the peptidase C19 family. (1609 aa)
RNF128E3 ubiquitin-protein ligase RNF128. (269 aa)
ATXN7L2Ataxin-7-like protein 2. (751 aa)
USP37Ubiquitin carboxyl-terminal hydrolase 37; Belongs to the peptidase C19 family. (1085 aa)
Y1Q_0008616HSA domain-containing protein. (1301 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
Y1Q_0013741Ubiquitin carboxyl-terminal hydrolase 2-like; Belongs to the peptidase C19 family. (179 aa)
USP44Ubiquitin carboxyl-terminal hydrolase. (545 aa)
RNF13E3 ubiquitin-protein ligase RNF13. (375 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (296 aa)
DDX58Putative ATP-dependent RNA helicase DDX58. (928 aa)
USP14Ubiquitin carboxyl-terminal hydrolase. (492 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (699 aa)
Y1Q_0014624USP domain-containing protein; Belongs to the peptidase C19 family. (228 aa)
USP19Ubiquitin carboxyl-terminal hydrolase 19 isoform A. (1473 aa)
RCE1CAAX prenyl protease 2. (286 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
USP44-2USP domain-containing protein; Belongs to the peptidase C19 family. (309 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (502 aa)
USP18Ubl carboxyl-terminal hydrolase 18; Belongs to the peptidase C19 family. (359 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
USP33Ubiquitin carboxyl-terminal hydrolase. (957 aa)
KEAP1Kelch-like ECH-associated protein 1. (480 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
NFKBIANF-kappa-B inhibitor alpha. (299 aa)
Y1Q_0008958Methyltransf_11 domain-containing protein. (301 aa)
Y1Q_0017259Myc_N domain-containing protein. (77 aa)
ARR3Arrestin-C isoform B. (428 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
PSME1Proteasome activator complex subunit 1. (150 aa)
USP10Ubiquitin carboxyl-terminal hydrolase. (665 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
Y1Q_0015578USP domain-containing protein; Belongs to the peptidase C19 family. (369 aa)
ARAndrogen receptor. (634 aa)
ARR3-2Arrestin_C domain-containing protein. (394 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
ATXN7L1Ataxin-7-like protein 1. (775 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMB11Proteasome subunit beta. (261 aa)
PSMB5Proteasome subunit beta type-5. (211 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2552 aa)
Y1Q_0002396USP domain-containing protein; Belongs to the peptidase C19 family. (85 aa)
UFD1LUbiquitin fusion degradation 1-like protein. (307 aa)
USP30Ubiquitin carboxyl-terminal hydrolase. (481 aa)
PSMD9-126S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
PSMB6Proteasome subunit beta. (227 aa)
Y1Q_0013191Ubiquitin carboxyl-terminal hydrolase. (570 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
Y1Q_0016604USP domain-containing protein; Belongs to the peptidase C19 family. (145 aa)
FKBP8Peptidylprolyl isomerase. (415 aa)
Y1Q_0013189Ubiquitin carboxyl-terminal hydrolase. (528 aa)
FOXO4Forkhead box protein O4. (480 aa)
UBFD1Ubiquitin domain-containing protein UBFD1. (260 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
BIRC7-1Baculoviral IAP repeat-containing protein 7 isoform A. (309 aa)
NPEPL1Putative aminopeptidase NPEPL1. (523 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
TNKS2Poly [ADP-ribose] polymerase. (1141 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1. (405 aa)
Y1Q_0000243E3 ubiquitin-protein ligase RNF13-like. (333 aa)
USP25Ubiquitin carboxyl-terminal hydrolase 25 isoform A; Belongs to the peptidase C19 family. (1147 aa)
ZNRF4Zinc/RING finger protein 4. (302 aa)
ZNRF4-2E3 ubiquitin-protein ligase RNF167-like. (317 aa)
IDEInsulin-degrading enzyme isoform A; Belongs to the peptidase M16 family. (1026 aa)
PSMF1Proteasome inhibitor PI31 subunit. (273 aa)
USP2USP domain-containing protein. (105 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (521 aa)
PSMB3Proteasome subunit beta. (205 aa)
DMWDDystrophia myotonica WD repeat-containing protein. (297 aa)
CDC20Cell division cycle 20-like protein. (427 aa)
AXIN1Uncharacterized protein. (892 aa)
BIRC2Inhibitor of apoptosis protein. (493 aa)
MYCMyc proto-oncogene protein. (169 aa)
CYLDLUbiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
WDR20Uncharacterized protein. (188 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
TADA2BTranscriptional adapter. (420 aa)
LAP3Cytosol aminopeptidase. (522 aa)
USP46-2USP domain-containing protein; Belongs to the peptidase C19 family. (357 aa)
BECN1Beclin-1. (467 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (518 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
WDR48WD repeat-containing protein 48. (677 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1500 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
USP15Ubiquitin carboxyl-terminal hydrolase. (982 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
PSMB2Proteasome subunit beta. (201 aa)
CLSPNClaspin. (1316 aa)
Y1Q_0010619Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (1690 aa)
Y1Q_0004030Uncharacterized protein. (147 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
NAIPBaculoviral IAP repeat-containing protein 1 isoform A. (878 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (257 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (28%) [HD]