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| | SLF1 | Ankyrin repeat domain-containing protein 32. (825 aa) |
| | POLD1 | DNA polymerase. (439 aa) |
| | Y1Q_0011106 | Short transient receptor potential channel 2-like. (506 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169 isoform B. (626 aa) |
| | POLD3-1 | DNA polymerase delta subunit 3 isoform A. (466 aa) |
| | GEN1 | Flap endonuclease GEN-like protein 1. (480 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (696 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa) |
| | Y1Q_0014479 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | XRCC2 | DNA repair protein XRCC2. (103 aa) |
| | Y1Q_0018383 | Histone H2B-like; Belongs to the histone H2B family. (152 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (284 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein. (832 aa) |
| | ATRIP | ATR-interacting protein. (672 aa) |
| | RFC1 | Replication factor C subunit 1. (1130 aa) |
| | NSD2 | Uncharacterized protein. (1370 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36. (261 aa) |
| | XRCC3 | DNA repair protein XRCC3. (388 aa) |
| | Y1Q_0014681 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa) |
| | RAD51AP1 | RAD51-associated protein 1. (315 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3063 aa) |
| | RHNO1 | RAD9. (261 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | Y1Q_0019415 | Uncharacterized protein. (85 aa) |
| | ANKRD11 | Ankyrin repeat domain-containing protein 11. (2899 aa) |
| | CTNNA3 | Catenin alpha-3. (157 aa) |
| | CMTR1-1 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (521 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa) |
| | Y1Q_0007595 | DNA_pol_B_exo1 domain-containing protein. (86 aa) |
| | BRE | BRCA1-A complex subunit BRE. (398 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1514 aa) |
| | Y1Q_0016180 | Uncharacterized protein. (89 aa) |
| | MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa) |
| | Y1Q_0012919 | Uncharacterized protein. (87 aa) |
| | Y1Q_0006787 | DNA polymerase delta catalytic subunit-like. (198 aa) |
| | FAM175A | BRCA1-A complex subunit Abraxas. (407 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (501 aa) |
| | SIRT6 | NAD-dependent protein deacetylase sirtuin-6. (357 aa) |
| | PIAS4 | E3 SUMO-protein ligase PIAS4. (541 aa) |
| | KXD1 | KxDL motif-containing protein 1. (293 aa) |
| | Y1Q_0000043 | Uncharacterized protein. (73 aa) |
| | Y1Q_0006757 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa) |
| | HIST1H4D | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | RAD9B-1 | Cell cycle checkpoint control protein RAD9B isoform B. (364 aa) |
| | SCARB1 | Scavenger receptor class B member 1 isoform A. (959 aa) |
| | HIST1H2B5L | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4 isoform A. (1385 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa) |
| | Y1Q_0000842 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa) |
| | Y1Q_0016099 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD52-1 | DNA repair RAD52-like protein isoform A. (467 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4 isoform C. (1726 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80 isoform B. (187 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12. (761 aa) |
| | Y1Q_0001015 | Reverse transcriptase domain-containing protein. (170 aa) |
| | TIMELESS | Timeless-like protein. (616 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1 isoform B. (792 aa) |
| | Y1Q_0008724 | Uncharacterized protein. (128 aa) |
| | MUS81 | Crossover junction endonuclease MUS81. (271 aa) |
| | Y1Q_0009388 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa) |
| | LIG3 | DNA ligase. (906 aa) |
| | RAD51D | DNA repair RAD51-like protein 4 isoform A. (415 aa) |
| | EME2 | Putative crossover junction endonuclease EME2. (451 aa) |
| | RAD51C | DNA repair RAD51-like protein 3. (367 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1443 aa) |
| | RFC2 | Replication factor C subunit 2. (340 aa) |
| | RFC5 | Replication factor C subunit 5. (336 aa) |
| | CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa) |
| | EME1 | Crossover junction endonuclease EME1. (282 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform A. (516 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2. (75 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1. (221 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1. (329 aa) |
| | Y1Q_0017935 | Reverse transcriptase domain-containing protein. (228 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (253 aa) |
| | XRCC1 | DNA repair protein XRCC1-like. (608 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (393 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa) |
| | POLD4 | DNA polymerase delta subunit 4 isoform A. (206 aa) |
| | BLM | Bloom syndrome protein. (1213 aa) |
| | MUS81L | Crossover junction endonuclease MUS81. (156 aa) |
| | RPA3 | Replication protein A subunit. (120 aa) |
| | CCNA1-1 | Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein isoform A. (1174 aa) |
| | Y1Q_0003896 | Reverse transcriptase domain-containing protein. (253 aa) |
| | SPIDR | DNA repair-scaffolding protein isoform A. (971 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (144 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | TP53BP1-1 | Tumor suppressor p53-binding protein 1 isoform A. (2124 aa) |
| | PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (695 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (589 aa) |
| | CDK2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | Y1Q_0018245 | Timeless-like protein. (364 aa) |
| | TDRD3 | Tudor domain-containing protein 3 isoform A. (743 aa) |
| | RCBTB1-2 | BTB domain-containing protein. (595 aa) |
| | POLH | DNA polymerase eta. (707 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (566 aa) |
| | EXO1 | Exonuclease 1. (775 aa) |
| | RPS27A | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | Y1Q_0019041 | XPGI domain-containing protein. (343 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (143 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (549 aa) |
| | Y1Q_0003135 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2 isoform A. (621 aa) |
| | RAD51B | DNA repair RAD51-like protein 2. (278 aa) |
| | Y1Q_0000419 | Uncharacterized protein. (78 aa) |
| | Y1Q_0001599 | Reverse transcriptase domain-containing protein. (173 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (338 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1. (524 aa) |
| | RAD50 | DNA repair protein RAD50. (1448 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | UIMC1L | BRCA1-A complex subunit RAP80 isoform B. (562 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (702 aa) |
| | SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (403 aa) |
| | HIST1H2BF | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Y1Q_0020100 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Y1Q_0020098 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N. (112 aa) |
| | Y1Q_0022362 | Histone H2B.3-like. (135 aa) |
| | 44G24.1 | Histone H2B.3; Belongs to the histone H2B family. (142 aa) |
| | POLD1-2 | DNA polymerase delta catalytic subunit. (392 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa) |
| | ANKRD31-1 | Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa) |
| | POLK | DNA polymerase kappa isoform A. (651 aa) |
| | RBBP8-1 | DNA endonuclease RBBP8 isoform B. (936 aa) |
| | BABAM1 | BRISC and BRCA1-A complex member 1. (325 aa) |
| | CCNA2 | Cyclin-A2; Belongs to the cyclin family. (382 aa) |
| | Y1Q_0012805 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
