STRINGSTRING
RPA1 RPA1 POLD1-2 POLD1-2 44G24.1 44G24.1 Y1Q_0022362 Y1Q_0022362 UBE2N UBE2N Y1Q_0020098 Y1Q_0020098 Y1Q_0020100 Y1Q_0020100 HIST2H2BE HIST2H2BE HIST1H2BF HIST1H2BF SIRT7 SIRT7 UIMC1L UIMC1L RFC4 RFC4 RAD50 RAD50 RMI1 RMI1 TIPIN TIPIN Y1Q_0001599 Y1Q_0001599 Y1Q_0000419 Y1Q_0000419 RAD51B RAD51B EXD2 EXD2 Y1Q_0003135 Y1Q_0003135 POLE3 POLE3 RPS27A RPS27A EXO1 EXO1 RCBTB1 RCBTB1 POLH POLH RCBTB1-2 RCBTB1-2 TDRD3 TDRD3 Y1Q_0018245 Y1Q_0018245 CDK2 CDK2 RNF168 RNF168 PPP4R2 PPP4R2 TP53BP1-1 TP53BP1-1 PPP4C PPP4C UBE2V2 UBE2V2 SPIDR SPIDR Y1Q_0003896 Y1Q_0003896 BRCA2 BRCA2 RFC3 RFC3 CCNA1-1 CCNA1-1 RPA3 RPA3 MUS81L MUS81L BLM BLM POLD4 POLD4 RAD9A RAD9A RAD51 RAD51 RAD1 RAD1 Y1Q_0017935 Y1Q_0017935 ERCC1 ERCC1 SLX1A SLX1A RMI2 RMI2 TOP3A TOP3A MEIOB MEIOB EME1 EME1 CDK3 CDK3 RFC5 RFC5 RFC2 RFC2 WRN WRN RAD51C RAD51C EME2 EME2 RAD51D RAD51D Y1Q_0009388 Y1Q_0009388 MUS81 MUS81 Y1Q_0008724 Y1Q_0008724 BARD1 BARD1 ATR ATR TIMELESS TIMELESS Y1Q_0001015 Y1Q_0001015 ANKRD12 ANKRD12 CHEK1 CHEK1 UIMC1 UIMC1 SLX4 SLX4 RAD52-1 RAD52-1 Y1Q_0016099 Y1Q_0016099 Y1Q_0000842 Y1Q_0000842 POLE POLE RECQL4 RECQL4 HIST1H2B5L HIST1H2B5L SCARB1 SCARB1 RAD9B-1 RAD9B-1 HIST1H4D HIST1H4D Y1Q_0006757 Y1Q_0006757 Y1Q_0000043 Y1Q_0000043 KXD1 KXD1 PIAS4 PIAS4 SIRT6 SIRT6 POLD2 POLD2 DNA2 DNA2 FAM175A FAM175A Y1Q_0006787 Y1Q_0006787 Y1Q_0012919 Y1Q_0012919 MRE11A MRE11A Y1Q_0016180 Y1Q_0016180 TOPBP1 TOPBP1 BRE BRE Y1Q_0007595 Y1Q_0007595 CMTR1-1 CMTR1-1 CTNNA3 CTNNA3 ANKRD11 ANKRD11 Y1Q_0019415 Y1Q_0019415 PCNA PCNA RHNO1 RHNO1 ATM ATM RAD51AP1 RAD51AP1 Y1Q_0014681 Y1Q_0014681 XRCC3 XRCC3 BRCC3 BRCC3 NSD2 NSD2 RFC1 RFC1 ATRIP ATRIP BRCA1 BRCA1 HUS1 HUS1 Y1Q_0018383 Y1Q_0018383 XRCC2 XRCC2 Y1Q_0014479 Y1Q_0014479 POLE2 POLE2 Y1Q_0012805 Y1Q_0012805 CCNA2 CCNA2 BABAM1 BABAM1 RBBP8-1 RBBP8-1 POLK POLK ANKRD31-1 ANKRD31-1 SLF1 SLF1 RAD17 RAD17 GEN1 GEN1 POLD3-1 POLD3-1 RNF169 RNF169 POLD1 POLD1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
POLD1-2DNA polymerase delta catalytic subunit. (392 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
UBE2NUbiquitin-conjugating enzyme E2 N. (112 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (403 aa)
UIMC1LBRCA1-A complex subunit RAP80 isoform B. (562 aa)
RFC4Replication factor C subunit 4. (364 aa)
RAD50DNA repair protein RAD50. (1448 aa)
RMI1RecQ-mediated genome instability protein 1. (524 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (338 aa)
Y1Q_0001599Reverse transcriptase domain-containing protein. (173 aa)
Y1Q_0000419Uncharacterized protein. (78 aa)
RAD51BDNA repair RAD51-like protein 2. (278 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2 isoform A. (621 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
POLE3DNA polymerase epsilon subunit 3. (143 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
EXO1Exonuclease 1. (775 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (566 aa)
POLHDNA polymerase eta. (707 aa)
RCBTB1-2BTB domain-containing protein. (595 aa)
TDRD3Tudor domain-containing protein 3 isoform A. (743 aa)
Y1Q_0018245Timeless-like protein. (364 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (589 aa)
PPP4R2Serine/threonine-protein phosphatase 4 regulatory subunit 2. (695 aa)
TP53BP1-1Tumor suppressor p53-binding protein 1 isoform A. (2124 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (144 aa)
SPIDRDNA repair-scaffolding protein isoform A. (971 aa)
Y1Q_0003896Reverse transcriptase domain-containing protein. (253 aa)
BRCA2Breast cancer type 2 susceptibility protein isoform A. (1174 aa)
RFC3Replication factor C subunit 3. (356 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
RPA3Replication protein A subunit. (120 aa)
MUS81LCrossover junction endonuclease MUS81. (156 aa)
BLMBloom syndrome protein. (1213 aa)
POLD4DNA polymerase delta subunit 4 isoform A. (206 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (393 aa)
RAD1Cell cycle checkpoint protein RAD1. (253 aa)
Y1Q_0017935Reverse transcriptase domain-containing protein. (228 aa)
ERCC1DNA excision repair protein ERCC-1. (329 aa)
SLX1AStructure-specific endonuclease subunit SLX1. (221 aa)
RMI2RecQ-mediated genome instability protein 2. (75 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
EME1Crossover junction endonuclease EME1. (282 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
RFC5Replication factor C subunit 5. (336 aa)
RFC2Replication factor C subunit 2. (340 aa)
WRNWerner syndrome ATP-dependent helicase. (1443 aa)
RAD51CDNA repair RAD51-like protein 3. (367 aa)
EME2Putative crossover junction endonuclease EME2. (451 aa)
RAD51DDNA repair RAD51-like protein 4 isoform A. (415 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
MUS81Crossover junction endonuclease MUS81. (271 aa)
Y1Q_0008724Uncharacterized protein. (128 aa)
BARD1BRCA1-associated RING domain protein 1 isoform B. (792 aa)
ATRSerine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa)
TIMELESSTimeless-like protein. (616 aa)
Y1Q_0001015Reverse transcriptase domain-containing protein. (170 aa)
ANKRD12Ankyrin repeat domain-containing protein 12. (761 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform B. (187 aa)
SLX4Structure-specific endonuclease subunit SLX4 isoform C. (1726 aa)
RAD52-1DNA repair RAD52-like protein isoform A. (467 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0000842DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
RECQL4ATP-dependent DNA helicase Q4 isoform A. (1385 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
RAD9B-1Cell cycle checkpoint control protein RAD9B isoform B. (364 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
Y1Q_0000043Uncharacterized protein. (73 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (541 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
POLD2DNA polymerase delta subunit 2. (501 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa)
FAM175ABRCA1-A complex subunit Abraxas. (407 aa)
Y1Q_0006787DNA polymerase delta catalytic subunit-like. (198 aa)
Y1Q_0012919Uncharacterized protein. (87 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
Y1Q_0016180Uncharacterized protein. (89 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1514 aa)
BREBRCA1-A complex subunit BRE. (398 aa)
Y1Q_0007595DNA_pol_B_exo1 domain-containing protein. (86 aa)
CMTR1-1E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (521 aa)
CTNNA3Catenin alpha-3. (157 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2899 aa)
Y1Q_0019415Uncharacterized protein. (85 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
RHNO1RAD9. (261 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
RAD51AP1RAD51-associated protein 1. (315 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
XRCC3DNA repair protein XRCC3. (388 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (261 aa)
NSD2Uncharacterized protein. (1370 aa)
RFC1Replication factor C subunit 1. (1130 aa)
ATRIPATR-interacting protein. (672 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
XRCC2DNA repair protein XRCC2. (103 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
BABAM1BRISC and BRCA1-A complex member 1. (325 aa)
RBBP8-1DNA endonuclease RBBP8 isoform B. (936 aa)
POLKDNA polymerase kappa isoform A. (651 aa)
ANKRD31-1Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa)
SLF1Ankyrin repeat domain-containing protein 32. (825 aa)
RAD17Cell cycle checkpoint protein RAD17. (696 aa)
GEN1Flap endonuclease GEN-like protein 1. (480 aa)
POLD3-1DNA polymerase delta subunit 3 isoform A. (466 aa)
RNF169E3 ubiquitin-protein ligase RNF169 isoform B. (626 aa)
POLD1DNA polymerase. (439 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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