STRINGSTRING
EYA1 EYA1 RNF169 RNF169 ANKRD31-1 ANKRD31-1 EYA3 EYA3 BABAM1 BABAM1 Y1Q_0012805 Y1Q_0012805 Y1Q_0014479 Y1Q_0014479 Y1Q_0018383 Y1Q_0018383 BRCA1 BRCA1 APBB2 APBB2 APBB2-2 APBB2-2 NSD2 NSD2 BRCC3 BRCC3 Y1Q_0014681 Y1Q_0014681 ATM ATM APBB1 APBB1 Y1Q_0008127 Y1Q_0008127 ANKRD11 ANKRD11 CTNNA3 CTNNA3 CMTR1-1 CMTR1-1 BRE BRE MRE11A MRE11A Y1Q_0012919 Y1Q_0012919 FAM175A FAM175A EYA2 EYA2 PIAS4 PIAS4 KXD1 KXD1 Y1Q_0000043 Y1Q_0000043 Y1Q_0006757 Y1Q_0006757 HIST1H4D HIST1H4D SCARB1 SCARB1 UBXN1 UBXN1 HIST1H2B5L HIST1H2B5L CHEK2 CHEK2 Y1Q_0016099 Y1Q_0016099 UIMC1 UIMC1 ANKRD12 ANKRD12 Y1Q_0001015 Y1Q_0001015 Y1Q_0018101 Y1Q_0018101 BARD1 BARD1 SUMO1 SUMO1 Y1Q_0009388 Y1Q_0009388 KPNA7 KPNA7 PPP5C PPP5C KPNA7-2 KPNA7-2 Y1Q_0017935 Y1Q_0017935 TP53 TP53 Y1Q_0003896 Y1Q_0003896 UBE2V2 UBE2V2 TP53BP1-1 TP53BP1-1 RNF168 RNF168 RPS27A RPS27A BAP1 BAP1 Y1Q_0003135 Y1Q_0003135 Y1Q_0001599 Y1Q_0001599 RAD50 RAD50 UIMC1L UIMC1L EYA4 EYA4 HIST1H2BF HIST1H2BF HIST2H2BE HIST2H2BE Y1Q_0020100 Y1Q_0020100 Y1Q_0020098 Y1Q_0020098 UBE2N UBE2N Y1Q_0022362 Y1Q_0022362 44G24.1 44G24.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (649 aa)
RNF169E3 ubiquitin-protein ligase RNF169 isoform B. (626 aa)
ANKRD31-1Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (727 aa)
BABAM1BRISC and BRCA1-A complex member 1. (325 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
APBB2Amyloid beta A4 protein-binding family B member 2. (344 aa)
APBB2-2WW domain-containing protein. (416 aa)
NSD2Uncharacterized protein. (1370 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (261 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
APBB1Amyloid beta A4 protein-binding family B member 1. (379 aa)
Y1Q_0008127Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2899 aa)
CTNNA3Catenin alpha-3. (157 aa)
CMTR1-1E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (521 aa)
BREBRCA1-A complex subunit BRE. (398 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
Y1Q_0012919Uncharacterized protein. (87 aa)
FAM175ABRCA1-A complex subunit Abraxas. (407 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (534 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (541 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
Y1Q_0000043Uncharacterized protein. (73 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
UBXN1UBX domain-containing protein 1. (320 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform B. (433 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform B. (187 aa)
ANKRD12Ankyrin repeat domain-containing protein 12. (761 aa)
Y1Q_0001015Reverse transcriptase domain-containing protein. (170 aa)
Y1Q_0018101F-box/LRR-repeat protein 16-like. (543 aa)
BARD1BRCA1-associated RING domain protein 1 isoform B. (792 aa)
SUMO1Small ubiquitin-related modifier. (93 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
KPNA7Importin subunit alpha; Belongs to the importin alpha family. (529 aa)
PPP5CSerine/threonine-protein phosphatase. (466 aa)
KPNA7-2Importin subunit alpha; Belongs to the importin alpha family. (518 aa)
Y1Q_0017935Reverse transcriptase domain-containing protein. (228 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
Y1Q_0003896Reverse transcriptase domain-containing protein. (253 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (144 aa)
TP53BP1-1Tumor suppressor p53-binding protein 1 isoform A. (2124 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (589 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (728 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
Y1Q_0001599Reverse transcriptase domain-containing protein. (173 aa)
RAD50DNA repair protein RAD50. (1448 aa)
UIMC1LBRCA1-A complex subunit RAP80 isoform B. (562 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
UBE2NUbiquitin-conjugating enzyme E2 N. (112 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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