STRINGSTRING
ERCC3 ERCC3 GTF2H5 GTF2H5 PARP2 PARP2 ERCC5 ERCC5 GTF2H4 GTF2H4 PIAS1 PIAS1 CHD1L CHD1L VTCN1 VTCN1 PARP3 PARP3 RPS27A RPS27A XPC XPC RAD23A RAD23A UBE2V2 UBE2V2 RPA3 RPA3 WDR76 WDR76 ERCC1 ERCC1 ERCC2 ERCC2 RNF111-1 RNF111-1 DDB2 DDB2 GTF2H1 GTF2H1 MEIOB MEIOB KCTD2 KCTD2 MNAT1 MNAT1 SUMO1 SUMO1 NFATC2IP NFATC2IP XPA XPA RAD23B RAD23B SUMO3 SUMO3 RBX1 RBX1 CUL4B CUL4B Y1Q_0015515 Y1Q_0015515 SCARB1 SCARB1 GTF2H3 GTF2H3 CCNH CCNH CETN3 CETN3 GTF2H2 GTF2H2 CDK7 CDK7 VWA5B1L VWA5B1L PARP1 PARP1 DDB1 DDB1 PIAS3 PIAS3 CUL4A CUL4A KXD1 KXD1 USP45 USP45 RPA1 RPA1 UBE2N UBE2N
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (779 aa)
GTF2H5General transcription factor IIH subunit 5. (115 aa)
PARP2Poly [ADP-ribose] polymerase. (702 aa)
ERCC5DNA repair protein complementing XP-G cells isoform B. (1152 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (404 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (651 aa)
CHD1LChromodomain-helicase-DNA-binding protein 1-like. (887 aa)
VTCN1V-set domain-containing T-cell activation inhibitor 1. (289 aa)
PARP3Poly [ADP-ribose] polymerase. (549 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
XPCDNA repair protein complementing XP-C cells. (955 aa)
RAD23AUV excision repair RAD23-like protein A. (357 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (144 aa)
RPA3Replication protein A subunit. (120 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (486 aa)
ERCC1DNA excision repair protein ERCC-1. (329 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
RNF111-1E3 ubiquitin-protein ligase Arkadia isoform A. (911 aa)
DDB2DNA damage-binding protein 2. (517 aa)
GTF2H1L-lactate dehydrogenase. (910 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
KCTD2BTB/POZ domain-containing protein KCTD2. (159 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
SUMO1Small ubiquitin-related modifier. (93 aa)
NFATC2IPNFATC2-interacting protein. (352 aa)
XPADNA repair protein complementing XP-A cells. (244 aa)
RAD23BUV excision repair RAD23-like protein B. (397 aa)
SUMO3Small ubiquitin-related modifier. (94 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (104 aa)
CUL4BCullin-4B; Belongs to the cullin family. (614 aa)
Y1Q_0015515Cullin domain-containing protein; Belongs to the cullin family. (160 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
GTF2H3General transcription factor IIH subunit 3. (328 aa)
CCNHCyclin-H; Belongs to the cyclin family. (247 aa)
CETN3Centrin-3. (167 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
VWA5B1LVon Willebrand factor A domain-containing protein 5B1 isoform C. (1274 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
PIAS3Uncharacterized protein. (641 aa)
CUL4ACULLIN_2 domain-containing protein; Belongs to the cullin family. (763 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
USP45Ubiquitin carboxyl-terminal hydrolase. (824 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
UBE2NUbiquitin-conjugating enzyme E2 N. (112 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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