STRINGSTRING
CDK7 CDK7 POLK POLK RPAP3 RPAP3 VWA5B1L VWA5B1L POLE2 POLE2 RFC1 RFC1 YY1 YY1 PCNA PCNA PARP1 PARP1 Y1Q_0007595 Y1Q_0007595 MCRS1 MCRS1 COPS4 COPS4 Y1Q_0006787 Y1Q_0006787 ACTR5 ACTR5 DDB1 DDB1 PIAS3 PIAS3 POLD2 POLD2 CUL4A CUL4A INO80E INO80E KXD1 KXD1 USP45 USP45 SCARB1 SCARB1 GTF2H3 GTF2H3 ERCC5 ERCC5 Y1Q_0015515 Y1Q_0015515 CUL4B CUL4B POLE POLE Y1Q_0000841 Y1Q_0000841 Y1Q_0000842 Y1Q_0000842 RBX1 RBX1 SUMO3 SUMO3 NFRKB NFRKB RAD23B RAD23B XPA XPA Y1Q_0008724 Y1Q_0008724 INO80D INO80D NFATC2IP NFATC2IP SUMO1 SUMO1 RFC2 RFC2 RFC5 RFC5 MNAT1 MNAT1 KCTD2 KCTD2 ATAD5 ATAD5 MEIOB MEIOB COPS3 COPS3 ERCC4 ERCC4 RNF111-1 RNF111-1 COPS2 COPS2 PIAS1 PIAS1 GPS1 GPS1 RFC4 RFC4 GTF2H4 GTF2H4 TFPT TFPT INO80C-1 INO80C-1 Y1Q_0024416 Y1Q_0024416 PARP2 PARP2 GTF2H5 GTF2H5 ERCC3 ERCC3 UBE2N UBE2N POLD1-2 POLD1-2 RPA1 RPA1 ACTR8 ACTR8 ERCC2 ERCC2 ERCC1 ERCC1 WBP1 WBP1 INO80 INO80 POLD4 POLD4 WDR76 WDR76 Y1Q_0020670 Y1Q_0020670 RPA3 RPA3 RFC3 RFC3 UBE2V2 UBE2V2 COPS5 COPS5 RAD23A RAD23A COPS7B COPS7B XPC XPC RUVBL1 RUVBL1 RCBTB1-2 RCBTB1-2 RCBTB1 RCBTB1 RPS27A RPS27A VTCN1 VTCN1 PARP3 PARP3 POLE3 POLE3 DDB2 DDB2 CHD1L CHD1L COPS7A COPS7A GTF2H1 GTF2H1 POLD1 POLD1 POLD3-1 POLD3-1 CCNH CCNH CETN3 CETN3 COPS6 COPS6 GTF2H2 GTF2H2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
POLKDNA polymerase kappa isoform A. (651 aa)
RPAP3RNA polymerase II-associated protein 3. (652 aa)
VWA5B1LVon Willebrand factor A domain-containing protein 5B1 isoform C. (1274 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
RFC1Replication factor C subunit 1. (1130 aa)
YY1Transcriptional repressor protein YY1. (243 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
Y1Q_0007595DNA_pol_B_exo1 domain-containing protein. (86 aa)
MCRS1Microspherule protein 1. (491 aa)
COPS4COP9 signalosome complex subunit 4. (190 aa)
Y1Q_0006787DNA polymerase delta catalytic subunit-like. (198 aa)
ACTR5Actin-related protein 5; Belongs to the actin family. (557 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
PIAS3Uncharacterized protein. (641 aa)
POLD2DNA polymerase delta subunit 2. (501 aa)
CUL4ACULLIN_2 domain-containing protein; Belongs to the cullin family. (763 aa)
INO80EINO80 complex subunit E isoform A. (253 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
USP45Ubiquitin carboxyl-terminal hydrolase. (824 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
GTF2H3General transcription factor IIH subunit 3. (328 aa)
ERCC5DNA repair protein complementing XP-G cells isoform B. (1152 aa)
Y1Q_0015515Cullin domain-containing protein; Belongs to the cullin family. (160 aa)
CUL4BCullin-4B; Belongs to the cullin family. (614 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
Y1Q_0000841DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (311 aa)
Y1Q_0000842DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (104 aa)
SUMO3Small ubiquitin-related modifier. (94 aa)
NFRKBNuclear factor related to kappa-B-binding protein isoform B. (1254 aa)
RAD23BUV excision repair RAD23-like protein B. (397 aa)
XPADNA repair protein complementing XP-A cells. (244 aa)
Y1Q_0008724Uncharacterized protein. (128 aa)
INO80DINO80 complex subunit D. (1029 aa)
NFATC2IPNFATC2-interacting protein. (352 aa)
SUMO1Small ubiquitin-related modifier. (93 aa)
RFC2Replication factor C subunit 2. (340 aa)
RFC5Replication factor C subunit 5. (336 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
KCTD2BTB/POZ domain-containing protein KCTD2. (159 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1673 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
COPS3COP9 signalosome complex subunit 3. (423 aa)
ERCC4DNA repair endonuclease XPF. (903 aa)
RNF111-1E3 ubiquitin-protein ligase Arkadia isoform A. (911 aa)
COPS2COP9 signalosome complex subunit 2 isoform B. (436 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (651 aa)
GPS1COP9 signalosome complex subunit 1 isoform A. (465 aa)
RFC4Replication factor C subunit 4. (364 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (404 aa)
TFPTTCF3 fusion partner. (251 aa)
INO80C-1INO80 complex subunit C isoform A. (188 aa)
Y1Q_0024416Uncharacterized protein. (127 aa)
PARP2Poly [ADP-ribose] polymerase. (702 aa)
GTF2H5General transcription factor IIH subunit 5. (115 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (779 aa)
UBE2NUbiquitin-conjugating enzyme E2 N. (112 aa)
POLD1-2DNA polymerase delta catalytic subunit. (392 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
ERCC1DNA excision repair protein ERCC-1. (329 aa)
WBP1WW domain-binding protein 1. (549 aa)
INO80DNA helicase INO80. (1539 aa)
POLD4DNA polymerase delta subunit 4 isoform A. (206 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (486 aa)
Y1Q_0020670COP9 signalosome complex subunit 4-like. (104 aa)
RPA3Replication protein A subunit. (120 aa)
RFC3Replication factor C subunit 3. (356 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (144 aa)
COPS5COP9 signalosome complex subunit 5. (149 aa)
RAD23AUV excision repair RAD23-like protein A. (357 aa)
COPS7BCOP9 signalosome complex subunit 7b. (293 aa)
XPCDNA repair protein complementing XP-C cells. (955 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
RCBTB1-2BTB domain-containing protein. (595 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (566 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
VTCN1V-set domain-containing T-cell activation inhibitor 1. (289 aa)
PARP3Poly [ADP-ribose] polymerase. (549 aa)
POLE3DNA polymerase epsilon subunit 3. (143 aa)
DDB2DNA damage-binding protein 2. (517 aa)
CHD1LChromodomain-helicase-DNA-binding protein 1-like. (887 aa)
COPS7ACOP9 signalosome complex subunit 7a. (291 aa)
GTF2H1L-lactate dehydrogenase. (910 aa)
POLD1DNA polymerase. (439 aa)
POLD3-1DNA polymerase delta subunit 3 isoform A. (466 aa)
CCNHCyclin-H; Belongs to the cyclin family. (247 aa)
CETN3Centrin-3. (167 aa)
COPS6COP9 signalosome complex subunit 6. (297 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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