47 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
	POLD1-2	DNA polymerase delta catalytic subunit. (392 aa)
	ERCC3	TFIIH basal transcription factor complex helicase XPB subunit. (779 aa)
	GTF2H5	General transcription factor IIH subunit 5. (115 aa)
	PARP2	Poly [ADP-ribose] polymerase. (702 aa)
	GTF2H4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (404 aa)
	RFC4	Replication factor C subunit 4. (364 aa)
	DDB2	DNA damage-binding protein 2. (517 aa)
	GTF2H1	L-lactate dehydrogenase. (910 aa)
	CHD1L	Chromodomain-helicase-DNA-binding protein 1-like. (887 aa)
	PARP3	Poly [ADP-ribose] polymerase. (549 aa)
	POLE3	DNA polymerase epsilon subunit 3. (143 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (156 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (566 aa)
	RCBTB1-2	BTB domain-containing protein. (595 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RPA3	Replication protein A subunit. (120 aa)
	POLD4	DNA polymerase delta subunit 4 isoform A. (206 aa)
	ERCC1	DNA excision repair protein ERCC-1. (329 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
	ERCC4	DNA repair endonuclease XPF. (903 aa)
	RFC5	Replication factor C subunit 5. (336 aa)
	RFC2	Replication factor C subunit 2. (340 aa)
	Y1Q_0008724	Uncharacterized protein. (128 aa)
	XPA	DNA repair protein complementing XP-A cells. (244 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1. (104 aa)
	Y1Q_0000842	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
	CUL4B	Cullin-4B; Belongs to the cullin family. (614 aa)
	Y1Q_0015515	Cullin domain-containing protein; Belongs to the cullin family. (160 aa)
	ERCC5	DNA repair protein complementing XP-G cells isoform B. (1152 aa)
	GTF2H3	General transcription factor IIH subunit 3. (328 aa)
	SCARB1	Scavenger receptor class B member 1 isoform A. (959 aa)
	KXD1	KxDL motif-containing protein 1. (293 aa)
	CUL4A	CULLIN_2 domain-containing protein; Belongs to the cullin family. (763 aa)
	POLD2	DNA polymerase delta subunit 2. (501 aa)
	DDB1	DNA damage-binding protein 1. (1140 aa)
	Y1Q_0006787	DNA polymerase delta catalytic subunit-like. (198 aa)
	Y1Q_0007595	DNA_pol_B_exo1 domain-containing protein. (86 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	RFC1	Replication factor C subunit 1. (1130 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
	POLK	DNA polymerase kappa isoform A. (651 aa)
	GTF2H2	General transcription factor IIH subunit. (395 aa)
	POLD3-1	DNA polymerase delta subunit 3 isoform A. (466 aa)
	POLD1	DNA polymerase. (439 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHD1L	CUL4A	A0A151MD12	A0A151NWT0	Chromodomain-helicase-DNA-binding protein 1-like.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.481
CHD1L	CUL4B	A0A151MD12	A0A151NN33	Chromodomain-helicase-DNA-binding protein 1-like.	Cullin-4B; Belongs to the cullin family.	0.481
CHD1L	DDB1	A0A151MD12	A0A151NYZ5	Chromodomain-helicase-DNA-binding protein 1-like.	DNA damage-binding protein 1.	0.654
CHD1L	DDB2	A0A151MD12	A0A151MB97	Chromodomain-helicase-DNA-binding protein 1-like.	DNA damage-binding protein 2.	0.744
CHD1L	ERCC1	A0A151MD12	A0A151MYI3	Chromodomain-helicase-DNA-binding protein 1-like.	DNA excision repair protein ERCC-1.	0.524
CHD1L	ERCC2	A0A151MD12	A0A151MYN4	Chromodomain-helicase-DNA-binding protein 1-like.	TFIIH basal transcription factor complex helicase XPD subunit.	0.628
CHD1L	ERCC3	A0A151MD12	A0A151M146	Chromodomain-helicase-DNA-binding protein 1-like.	TFIIH basal transcription factor complex helicase XPB subunit.	0.677
CHD1L	ERCC4	A0A151MD12	A0A151N1B4	Chromodomain-helicase-DNA-binding protein 1-like.	DNA repair endonuclease XPF.	0.665
CHD1L	ERCC5	A0A151MD12	A0A151NRB9	Chromodomain-helicase-DNA-binding protein 1-like.	DNA repair protein complementing XP-G cells isoform B.	0.697
CHD1L	GTF2H1	A0A151MD12	A0A151MCB3	Chromodomain-helicase-DNA-binding protein 1-like.	L-lactate dehydrogenase.	0.623
CHD1L	GTF2H2	A0A151MD12	A0A151PHY7	Chromodomain-helicase-DNA-binding protein 1-like.	General transcription factor IIH subunit.	0.607
CHD1L	GTF2H3	A0A151MD12	A0A151NRY4	Chromodomain-helicase-DNA-binding protein 1-like.	General transcription factor IIH subunit 3.	0.606
CHD1L	GTF2H4	A0A151MD12	A0A151M5U1	Chromodomain-helicase-DNA-binding protein 1-like.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.431
CHD1L	GTF2H5	A0A151MD12	A0A151M2E2	Chromodomain-helicase-DNA-binding protein 1-like.	General transcription factor IIH subunit 5.	0.646
CHD1L	KXD1	A0A151MD12	A0A151NUA6	Chromodomain-helicase-DNA-binding protein 1-like.	KxDL motif-containing protein 1.	0.619
CHD1L	PARP1	A0A151MD12	A0A151P373	Chromodomain-helicase-DNA-binding protein 1-like.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.878
CHD1L	PARP2	A0A151MD12	A0A151M3N3	Chromodomain-helicase-DNA-binding protein 1-like.	Poly [ADP-ribose] polymerase.	0.802
CHD1L	PARP3	A0A151MD12	A0A151MER1	Chromodomain-helicase-DNA-binding protein 1-like.	Poly [ADP-ribose] polymerase.	0.646
CHD1L	PCNA	A0A151MD12	A0A151P620	Chromodomain-helicase-DNA-binding protein 1-like.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.532
CHD1L	POLE3	A0A151MD12	A0A151MEU2	Chromodomain-helicase-DNA-binding protein 1-like.	DNA polymerase epsilon subunit 3.	0.646