STRINGSTRING
SLF1 SLF1 ANKRD31-1 ANKRD31-1 RBBP8-1 RBBP8-1 TAF4B TAF4B MAPK11 MAPK11 MDM2 MDM2 DYRK2 DYRK2 CCNA2 CCNA2 PRKAG2 PRKAG2 HUS1 HUS1 CDK5R1 CDK5R1 BRCA1 BRCA1 ATRIP ATRIP ATM ATM Y1Q_0002398 Y1Q_0002398 PRKAG1 PRKAG1 DYRK4 DYRK4 RHNO1 RHNO1 ANKRD11 ANKRD11 TOPBP1 TOPBP1 Y1Q_0016180 Y1Q_0016180 Y1Q_0016784 Y1Q_0016784 MRE11A MRE11A STK11 STK11 TP53INP2 TP53INP2 DNA2 DNA2 TP53RK TP53RK AURKA AURKA TAF4 TAF4 TAF11 TAF11 CSNK2A1 CSNK2A1 PIN1 PIN1 SSRP1 SSRP1 TAF5 TAF5 KXD1 KXD1 TAF1 TAF1 RAD9B-1 RAD9B-1 SCARB1 SCARB1 MAPKAPK5 MAPKAPK5 CDK5R2 CDK5R2 SUPT16H SUPT16H CSNK2B CSNK2B TAF3 TAF3 TAF9B TAF9B TAF7L TAF7L RECQL4 RECQL4 NUAK1 NUAK1 HIPK2 HIPK2 DCLRE1B DCLRE1B CHEK1 CHEK1 ANKRD12 ANKRD12 Y1Q_0004744 Y1Q_0004744 ATR ATR BARD1 BARD1 MAPK14 MAPK14 Y1Q_0007802 Y1Q_0007802 Y1Q_0012818 Y1Q_0012818 WRN WRN RFC2 RFC2 RFC5 RFC5 PRKAB1 PRKAB1 NOC2L NOC2L CDK3 CDK3 MEIOB MEIOB TOP3A TOP3A RMI2 RMI2 TAF10 TAF10 TP53INP1-1 TP53INP1-1 TAF2 TAF2 PRKAA1-2 PRKAA1-2 RAD1 RAD1 TP53 TP53 RAD9A RAD9A BLM BLM CSNK2A2 CSNK2A2 TAF6-1 TAF6-1 Y1Q_0020755 Y1Q_0020755 RPA3 RPA3 CDK5R1L CDK5R1L CCNA1-1 CCNA1-1 RFC3 RFC3 AURKB AURKB HIPK4 HIPK4 CDK2 CDK2 TDRD3 TDRD3 EXO1 EXO1 RPS27A RPS27A TAF13 TAF13 Y1Q_0000620 Y1Q_0000620 EXD2 EXD2 MDM4 MDM4 NUAK2 NUAK2 DYRK3 DYRK3 RMI1 RMI1 RAD50 RAD50 RFC4 RFC4 PRKAA1 PRKAA1 TBPL1 TBPL1 TAF5L TAF5L TBP TBP TBPL2 TBPL2 RPA1 RPA1 RAD17 RAD17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLF1Ankyrin repeat domain-containing protein 32. (825 aa)
ANKRD31-1Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa)
RBBP8-1DNA endonuclease RBBP8 isoform B. (936 aa)
TAF4BProteasome endopeptidase complex; Belongs to the peptidase T1A family. (1010 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (526 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (567 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (306 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
ATRIPATR-interacting protein. (672 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
Y1Q_0002398Uncharacterized protein. (72 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform A. (330 aa)
DYRK4Dual specificity tyrosine-phosphorylation-regulated kinase 4 isoform B. (710 aa)
RHNO1RAD9. (261 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2899 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1514 aa)
Y1Q_0016180Uncharacterized protein. (89 aa)
Y1Q_00167845'-AMP-activated protein kinase subunit gamma-3-like. (129 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (418 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (152 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa)
TP53RKTP53-regulating kinase. (383 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (450 aa)
TAF4Transcription initiation factor TFIID subunit 4. (976 aa)
TAF11Transcription initiation factor TFIID subunit 11. (153 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (435 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (159 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (705 aa)
TAF5Transcription initiation factor TFIID subunit 5. (655 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
TAF1Transcription initiation factor TFIID subunit. (1966 aa)
RAD9B-1Cell cycle checkpoint control protein RAD9B isoform B. (364 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform B. (510 aa)
CDK5R2Cyclin-dependent kinase 5 activator 2. (278 aa)
SUPT16HFACT complex subunit SPT16. (1044 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa)
TAF3Transcription initiation factor TFIID subunit 3 isoform C. (1040 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (255 aa)
TAF7LTranscription initiation factor TFIID subunit 7-like. (353 aa)
RECQL4ATP-dependent DNA helicase Q4 isoform A. (1385 aa)
NUAK1NUAK family SNF1-like kinase 1. (651 aa)
HIPK2Protein kinase domain-containing protein. (1175 aa)
DCLRE1B5' exonuclease Apollo isoform B. (1619 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
ANKRD12Ankyrin repeat domain-containing protein 12. (761 aa)
Y1Q_0004744Protein kinase domain-containing protein. (161 aa)
ATRSerine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa)
BARD1BRCA1-associated RING domain protein 1 isoform B. (792 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Y1Q_0007802Transcription initiation factor TFIID subunit 4-like. (750 aa)
Y1Q_0012818Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (341 aa)
WRNWerner syndrome ATP-dependent helicase. (1443 aa)
RFC2Replication factor C subunit 2. (340 aa)
RFC5Replication factor C subunit 5. (336 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (302 aa)
NOC2LNucleolar complex 2-like protein. (785 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa)
RMI2RecQ-mediated genome instability protein 2. (75 aa)
TAF10Transcription initiation factor TFIID subunit 10. (121 aa)
TP53INP1-1Tumor protein p53-inducible nuclear protein 1 isoform B. (225 aa)
TAF2Transcription initiation factor TFIID subunit 2. (1145 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
RAD1Cell cycle checkpoint protein RAD1. (253 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa)
BLMBloom syndrome protein. (1213 aa)
CSNK2A2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (392 aa)
TAF6-1Transcription initiation factor TFIID subunit 6 isoform A. (666 aa)
Y1Q_00207555'-AMP-activated protein kinase subunit gamma-3-like. (99 aa)
RPA3Replication protein A subunit. (120 aa)
CDK5R1LCyclin-dependent kinase 5 activator 1. (295 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
RFC3Replication factor C subunit 3. (356 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (372 aa)
HIPK4Homeodomain-interacting protein kinase 4. (514 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
TDRD3Tudor domain-containing protein 3 isoform A. (743 aa)
EXO1Exonuclease 1. (775 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
Y1Q_0000620Protein kinase domain-containing protein. (901 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2 isoform A. (621 aa)
MDM4Protein Mdm4. (513 aa)
NUAK2Protein kinase domain-containing protein. (615 aa)
DYRK3Protein kinase domain-containing protein. (581 aa)
RMI1RecQ-mediated genome instability protein 1. (524 aa)
RAD50DNA repair protein RAD50. (1448 aa)
RFC4Replication factor C subunit 4. (364 aa)
PRKAA1Non-specific serine/threonine protein kinase. (527 aa)
TBPL1TATA box-binding protein-like protein 1. (255 aa)
TAF5LTAF5-like RNA polymerase II p300/CBP-associated factor-associated factor subunit 5L. (576 aa)
TBPTATA-box-binding protein. (301 aa)
TBPL2TATA box-binding protein-like protein 2. (331 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
RAD17Cell cycle checkpoint protein RAD17. (696 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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