STRINGSTRING
PRR5 PRR5 RFFL RFFL MLST8 MLST8 MDM2 MDM2 CCNA2 CCNA2 Y1Q_0017424 Y1Q_0017424 ATM ATM CDK1 CDK1 TP53 TP53 RICTOR RICTOR MAPKAP1 MAPKAP1 KXD1 KXD1 AKT3 AKT3 CCNG1 CCNG1 PPP2CA PPP2CA MDM4 MDM4 PPP2R1A PPP2R1A RPS27A RPS27A AKT3-2 AKT3-2 PDPK1 PDPK1 CDK2 CDK2 CCNA1-1 CCNA1-1 AKT2 AKT2 USP7 USP7 TXNDC11 TXNDC11 RNF34 RNF34 SCARB1 SCARB1 DAXX DAXX CDK3 CDK3 MTOR MTOR PPP2CB PPP2CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRR5Proline-rich protein 5 isoform B. (468 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (348 aa)
MLST8Target of rapamycin complex subunit LST8. (403 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
Y1Q_0017424Uncharacterized protein. (235 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RICTORRapamycin-insensitive companion of mTOR. (1439 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (540 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CCNG1Cyclin-G1; Belongs to the cyclin family. (256 aa)
PPP2CASerine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
MDM4Protein Mdm4. (513 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform. (643 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
AKT3-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (515 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
AKT2Non-specific serine/threonine protein kinase. (270 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1080 aa)
TXNDC11Thioredoxin domain-containing protein 11. (901 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (345 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
DAXXDeath domain-associated protein 6 isoform A. (758 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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