20 items (Alligator mississippiensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	POU4F1	POU domain protein. (193 aa)
	ZNF385B	Zinc finger protein 385B isoform B. (505 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	POU4F3-1	POU domain protein. (337 aa)
	AKT3-2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
	AKT2	Non-specific serine/threonine protein kinase. (270 aa)
	ZNF385D-2	U1-type domain-containing protein. (92 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	PPP1R13L	RelA-associated inhibitor. (797 aa)
	Y1Q_0006003	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (688 aa)
	BANP	Protein BANP. (508 aa)
	PHF20	PHD finger protein 20. (1058 aa)
	PPP1R13B	Apoptosis-stimulating of p53 protein 1. (1153 aa)
	POU4F3-2	POU domain protein. (316 aa)
	PPP1R13BB	Apoptosis-stimulating of p53 protein 1 isoform D. (1133 aa)
	POU4F2	POU domain protein. (316 aa)
	Y1Q_0017424	Uncharacterized protein. (235 aa)
	ZNF385C-1	Zinc finger protein 385C isoform A. (1099 aa)
	Y1Q_0010122	Uncharacterized protein. (300 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	A0A151MPY5	A0A151M239	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT2	AKT3-2	A0A151MPY5	A0A151MH49	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT2	PHF20	A0A151MPY5	A0A151NW92	Non-specific serine/threonine protein kinase.	PHD finger protein 20.	0.462
AKT2	TP53	A0A151MPY5	A0A151MW63	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.591
AKT2	Y1Q_0017424	A0A151MPY5	A0A151PCN9	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.899
AKT3	AKT2	A0A151M239	A0A151MPY5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.902
AKT3	AKT3-2	A0A151M239	A0A151MH49	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT3	PHF20	A0A151M239	A0A151NW92	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PHD finger protein 20.	0.462
AKT3	TP53	A0A151M239	A0A151MW63	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.591
AKT3-2	AKT2	A0A151MH49	A0A151MPY5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.902
AKT3-2	AKT3	A0A151MH49	A0A151M239	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT3-2	PHF20	A0A151MH49	A0A151NW92	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PHD finger protein 20.	0.462
BANP	TP53	A0A151NCN7	A0A151MW63	Protein BANP.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.757
BANP	TP63	A0A151NCN7	A0A151MM54	Protein BANP.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.544
BANP	Y1Q_0006003	A0A151NCN7	A0A151N3K6	Protein BANP.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.544
PHF20	AKT2	A0A151NW92	A0A151MPY5	PHD finger protein 20.	Non-specific serine/threonine protein kinase.	0.462
PHF20	AKT3	A0A151NW92	A0A151M239	PHD finger protein 20.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.462
PHF20	AKT3-2	A0A151NW92	A0A151MH49	PHD finger protein 20.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.462
PHF20	TP53	A0A151NW92	A0A151MW63	PHD finger protein 20.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.818
PHF20	Y1Q_0017424	A0A151NW92	A0A151PCN9	PHD finger protein 20.	Uncharacterized protein.	0.462