STRINGSTRING
WDR64 WDR64 STRN3 STRN3 KITLG KITLG RHOG RHOG MORN2-1 MORN2-1 CD86 CD86 PPP2R5E PPP2R5E ESR2 ESR2 FAM102B FAM102B Y1Q_0012336 Y1Q_0012336 PIK3CB-2 PIK3CB-2 PIK3CB PIK3CB Y1Q_0010680 Y1Q_0010680 FGF1-1 FGF1-1 PPP2CA PPP2CA FNDC3A FNDC3A FAM102A FAM102A PIP5KL1 PIP5KL1 PPP2R5D PPP2R5D PPP2R1A PPP2R1A INSC INSC INS INS FGF19 FGF19 FNBP4 FNBP4 FGF4 FGF4 FGF3 FGF3 TRAF6 TRAF6 NRG4 NRG4 FGF7-2 FGF7-2 PIP5K1B PIP5K1B PIK3AP1-1 PIK3AP1-1 PIP4K2C PIP4K2C Y1Q_0003612 Y1Q_0003612 IRAK4 IRAK4 FRS2 FRS2 MET-2 MET-2 FGF2 FGF2 PIP4K2A PIP4K2A PDGFRA-2 PDGFRA-2 FGF20 FGF20 KIT-2 KIT-2 FGFR3 FGFR3 PPP4R4 PPP4R4 PPP2R5C-2 PPP2R5C-2 FGF9 FGF9 FGF6 FGF6 FGF23 FGF23 PIP4K2B PIP4K2B ERBB2 ERBB2 TGFA TGFA PPP2R5C PPP2R5C EGFR EGFR Y1Q_0017491 Y1Q_0017491 Y1Q_0017492 Y1Q_0017492 FGF22 FGF22 PPP4R1 PPP4R1 IL1RL1-1 IL1RL1-1 FGFR2-2 FGFR2-2 STRN4 STRN4 PTPN11 PTPN11 FGF18 FGF18 NRG2 NRG2 NRG2-2 NRG2-2 HBEGF-1 HBEGF-1 Y1Q_0023424 Y1Q_0023424 HGF HGF NPM3 NPM3 Y1Q_0015649 Y1Q_0015649 FGF16 FGF16 Y1Q_0011870 Y1Q_0011870 BANK1 BANK1 ESR1 ESR1 STRN3-2 STRN3-2 PDGFB PDGFB Y1Q_0003573 Y1Q_0003573 Y1Q_0008090 Y1Q_0008090 PPP4R1-2 PPP4R1-2 NRG1-1 NRG1-1 PIP5K1C PIP5K1C FGFR2 FGFR2 FGF17-1 FGF17-1 ERBB4 ERBB4 CD28 CD28 PIK3R1 PIK3R1 FGF13-1 FGF13-1 EPGN EPGN EREG EREG PPP2CB PPP2CB BTC BTC GAB2 GAB2 Y1Q_0006103 Y1Q_0006103 PIK3CD PIK3CD GRB2 GRB2 FGFR4 FGFR4 PDGFA-1 PDGFA-1 PIK3R1-2 PIK3R1-2 FGF10 FGF10 ERBB3 ERBB3 PPP2R5B PPP2R5B Y1Q_0005265 Y1Q_0005265 NRG3 NRG3 FLT3 FLT3 FGF5 FGF5 Y1Q_0018542 Y1Q_0018542 GAB1 GAB1 PDGFRA PDGFRA IL1RAP-1 IL1RAP-1 CD276 CD276 FNDC3A-2 FNDC3A-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR64WD repeat-containing protein 64. (1106 aa)
STRN3Striatin-3 isoform B. (784 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (277 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
MORN2-1MORN repeat-containing protein 2 isoform A. (138 aa)
CD86T-lymphocyte activation antigen CD86. (344 aa)
PPP2R5ESerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (515 aa)
ESR2Estrogen receptor beta. (406 aa)
FAM102BProtein FAM102B. (361 aa)
Y1Q_0012336PIPK domain-containing protein. (608 aa)
PIK3CB-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Y1Q_0010680Uncharacterized protein. (176 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PPP2CASerine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1011 aa)
FAM102AProtein FAM102A. (383 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (440 aa)
PPP2R5DSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (596 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform. (643 aa)
INSCInscuteable-like protein isoform B. (553 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (147 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
FNBP4Formin-binding protein 4 isoform B. (904 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (576 aa)
NRG4Pro-neuregulin-4, membrane-bound. (115 aa)
FGF7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
PIP5K1BPIPK domain-containing protein. (618 aa)
PIK3AP1-1Phosphoinositide 3-kinase adapter protein 1 isoform A. (867 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (458 aa)
Y1Q_0003612Rho-GAP domain-containing protein. (189 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (468 aa)
FRS2Fibroblast growth factor receptor substrate 2. (510 aa)
MET-2Uncharacterized protein. (1348 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PIP4K2APIPK domain-containing protein. (405 aa)
PDGFRA-2Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1166 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
KIT-2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (947 aa)
FGFR3Fibroblast growth factor receptor. (837 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform A. (864 aa)
PPP2R5C-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (602 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (411 aa)
ERBB2Receptor protein-tyrosine kinase. (1262 aa)
TGFAProtransforming growth factor alpha. (159 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (479 aa)
EGFRUncharacterized protein. (633 aa)
Y1Q_0017491Uncharacterized protein. (138 aa)
Y1Q_0017492Protein kinase domain-containing protein. (493 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (141 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (956 aa)
IL1RL1-1Interleukin-1 receptor-like 1 isoform A. (548 aa)
FGFR2-2Fibroblast growth factor receptor. (783 aa)
STRN4WD_REPEATS_REGION domain-containing protein. (563 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform D. (675 aa)
NRG2-2Uncharacterized protein. (261 aa)
HBEGF-1Proheparin-binding EGF-like growth factor isoform B. (205 aa)
Y1Q_0023424Ig-like domain-containing protein. (156 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (723 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
Y1Q_0015649Uncharacterized protein. (1191 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Y1Q_0011870Pkinase_Tyr domain-containing protein. (94 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform B. (788 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
STRN3-2WD_REPEATS_REGION domain-containing protein. (712 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
Y1Q_0003573SH3 domain-containing protein. (167 aa)
Y1Q_0008090LisH domain-containing protein. (1143 aa)
PPP4R1-2WRNPLPNID domain-containing protein. (952 aa)
NRG1-1Pro-neuregulin-1, membrane-bound isoform C. (636 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (637 aa)
FGFR2Fibroblast growth factor receptor. (818 aa)
FGF17-1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ERBB4Receptor protein-tyrosine kinase. (1335 aa)
CD28T-cell-specific surface glycoprotein CD28. (226 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
FGF13-1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
EPGNEpigen isoform B. (150 aa)
EREGProepiregulin. (159 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
BTCProbetacellulin. (170 aa)
GAB2GRB2-associated-binding protein 2. (677 aa)
Y1Q_0006103Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGFR4Uncharacterized protein. (518 aa)
PDGFA-1Platelet-derived growth factor subunit A isoform B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PIK3R1-2Uncharacterized protein. (750 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
ERBB3Protein kinase domain-containing protein. (1303 aa)
PPP2R5BSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (493 aa)
Y1Q_0005265Uncharacterized protein. (212 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform A. (353 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1110 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
Y1Q_0018542Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
GAB1GRB2-associated-binding protein 1 isoform A. (720 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1097 aa)
IL1RAP-1Interleukin-1 receptor accessory protein isoform B. (852 aa)
CD276CD276 antigen isoform A. (338 aa)
FNDC3A-2Uncharacterized protein. (1195 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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