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SCARB1 SCARB1 PSMD13 PSMD13 CDC16 CDC16 KXD1 KXD1 PSMB6 PSMB6 Y1Q_0006757 Y1Q_0006757 HIST1H4D HIST1H4D CDC45 CDC45 PSMD4 PSMD4 ANAPC5 ANAPC5 ANAPC7 ANAPC7 PSMD9-1 PSMD9-1 ANAPC11 ANAPC11 PSMB5 PSMB5 PSMC2 PSMC2 MCM10 MCM10 ORC5 ORC5 H2AFV H2AFV PSMD7 PSMD7 HIST1H2B5L HIST1H2B5L PSMD10 PSMD10 H2AFZ H2AFZ PSME1 PSME1 PSME2 PSME2 PSMA6 PSMA6 POLE POLE Y1Q_0000841 Y1Q_0000841 Y1Q_0000842 Y1Q_0000842 Y1Q_0016099 Y1Q_0016099 MCM5 MCM5 PSMC4 PSMC4 FZR1 FZR1 GMNN GMNN MCM3 MCM3 ORC2 ORC2 Y1Q_0008724 Y1Q_0008724 PSMC5 PSMC5 PSMA5 PSMA5 Y1Q_0009388 Y1Q_0009388 Y1Q_0019034 Y1Q_0019034 CDK3 CDK3 PSMD12 PSMD12 MEIOB MEIOB POLA1 POLA1 Y1Q_0005128 Y1Q_0005128 PSMD1 PSMD1 ANAPC10 ANAPC10 CDT1 CDT1 ORC3 ORC3 POLA2 POLA2 ORC6 ORC6 RPA3 RPA3 TM7SF3 TM7SF3 MCM4 MCM4 Y1Q_0003907 Y1Q_0003907 KPNA6 KPNA6 PSMB9 PSMB9 PSMB8 PSMB8 PSMD6 PSMD6 MCM2 MCM2 TM4SF19 TM4SF19 CDK2 CDK2 CDC23 CDC23 MCM8 MCM8 RPS27A RPS27A UBE2S UBE2S PSMB7 PSMB7 PSMD5-1 PSMD5-1 CDC26 CDC26 ANAPC2 ANAPC2 POLE3 POLE3 Y1Q_0003135 Y1Q_0003135 PSMA1 PSMA1 PSMC3 PSMC3 HYKK HYKK ANAPC15 ANAPC15 RPA1 RPA1 44G24.1 44G24.1 Y1Q_0022362 Y1Q_0022362 Y1Q_0020098 Y1Q_0020098 Y1Q_0020100 Y1Q_0020100 HIST2H2BE HIST2H2BE HIST1H2BF HIST1H2BF PSMD14 PSMD14 ORC4 ORC4 MCM6 MCM6 ANAPC1 ANAPC1 KPNA1 KPNA1 PSMA3 PSMA3 PSMB1 PSMB1 KPNA5 KPNA5 MCM9 MCM9 MCM9L MCM9L ORC1 ORC1 CDC7-1 CDC7-1 PSMB4 PSMB4 PSMD8 PSMD8 MCM7 MCM7 PSMB2 PSMB2 UBE2C UBE2C Y1Q_0012805 Y1Q_0012805 PSMC6 PSMC6 POLE2 POLE2 PRIM2 PRIM2 Y1Q_0014479 Y1Q_0014479 Y1Q_0018383 Y1Q_0018383 CDC6 CDC6 PSMD11 PSMD11 CDC27 CDC27 PRIM1 PRIM1 ANAPC4 ANAPC4 PSMC1 PSMC1 PSMD2 PSMD2 Y1Q_0014681 Y1Q_0014681 PSMB3 PSMB3 PSMD3 PSMD3 GLTSCR1-1 GLTSCR1-1 PSMF1 PSMF1 ANAPC16 ANAPC16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
CDC16Cell division cycle 16-like protein. (622 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
PSMB6Proteasome subunit beta. (227 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CDC45Cell division control 45-like protein. (501 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa)
ANAPC5Anaphase-promoting complex subunit 5. (756 aa)
ANAPC7Anaphase-promoting complex subunit 7. (608 aa)
PSMD9-126S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa)
ANAPC11Anaphase-promoting complex subunit 11. (98 aa)
PSMB5Proteasome subunit beta type-5. (211 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
MCM10MCM10-like protein. (868 aa)
ORC5Origin recognition complex subunit 5. (420 aa)
H2AFVHistone H2A; Belongs to the histone H2A family. (128 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
PSME1Proteasome activator complex subunit 1. (150 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
Y1Q_0000841DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (311 aa)
Y1Q_0000842DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
MCM5DNA helicase; Belongs to the MCM family. (773 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
FZR1Fizzy-related protein-like protein. (493 aa)
GMNNGeminin. (223 aa)
MCM3DNA helicase; Belongs to the MCM family. (772 aa)
ORC2Origin recognition complex subunit 2. (569 aa)
Y1Q_0008724Uncharacterized protein. (128 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
Y1Q_0019034RPN1_C domain-containing protein. (356 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (441 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
POLA1DNA polymerase. (1498 aa)
Y1Q_0005128Proteasome subunit beta. (277 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (179 aa)
CDT1DNA replication factor Cdt1. (516 aa)
ORC3Origin recognition complex subunit 3 isoform A. (713 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (597 aa)
ORC6Origin recognition complex subunit 6. (267 aa)
RPA3Replication protein A subunit. (120 aa)
TM7SF3Transmembrane 7 superfamily member 3. (581 aa)
MCM4DNA helicase; Belongs to the MCM family. (861 aa)
Y1Q_0003907MCM domain-containing protein. (120 aa)
KPNA6Importin subunit alpha; Belongs to the importin alpha family. (551 aa)
PSMB9Proteasome subunit beta. (216 aa)
PSMB8Proteasome subunit beta. (282 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (348 aa)
MCM2DNA helicase; Belongs to the MCM family. (888 aa)
TM4SF19Transmembrane 4 L6 family member 19. (205 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CDC23Cell division cycle 23-like protein isoform B. (585 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (795 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (215 aa)
PSMB7Proteasome subunit beta. (274 aa)
PSMD5-126S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa)
CDC26Anaphase-promoting complex subunit CDC26. (84 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (675 aa)
POLE3DNA polymerase epsilon subunit 3. (143 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
PSMA1Proteasome subunit alpha type. (261 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
HYKKProteasome endopeptidase complex. (600 aa)
ANAPC15Anaphase-promoting complex subunit 15. (94 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (460 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
MCM6DNA helicase; Belongs to the MCM family. (822 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1942 aa)
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (515 aa)
PSMA3Proteasome subunit alpha type. (256 aa)
PSMB1Proteasome subunit beta. (240 aa)
KPNA5Importin subunit alpha; Belongs to the importin alpha family. (539 aa)
MCM9DNA helicase MCM9; Belongs to the MCM family. (463 aa)
MCM9LDNA helicase MCM9. (752 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (949 aa)
CDC7-1Cell division cycle 7-related protein kinase isoform B. (672 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (257 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PSMB2Proteasome subunit beta. (201 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (503 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (549 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (518 aa)
CDC27Cell division cycle 27-like protein. (834 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (456 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (796 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2. (513 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (521 aa)
GLTSCR1-1Glioma tumor suppressor candidate region 1 protein isoform C. (1814 aa)
PSMF1Proteasome inhibitor PI31 subunit. (273 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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