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| | HIST1H2B5L | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10. (226 aa) |
| | PSME1 | Proteasome activator complex subunit 1. (150 aa) |
| | PSME2 | Proteasome activator complex subunit 2. (242 aa) |
| | SFN | 14-3-3 protein sigma; Belongs to the 14-3-3 family. (246 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform B. (433 aa) |
| | PSMA6 | Proteasome subunit alpha type. (252 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4 isoform A. (1385 aa) |
| | Y1Q_0016099 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | WEE2-1 | Wee1-like protein kinase. (592 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (773 aa) |
| | PSMC4 | 26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa) |
| | PIEZO2-2 | Piezo-type mechanosensitive ion channel component. (2595 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12. (761 aa) |
| | Y1Q_0001015 | Reverse transcriptase domain-containing protein. (170 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (772 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1 isoform B. (792 aa) |
| | ORC2 | Origin recognition complex subunit 2. (569 aa) |
| | PSMC5 | Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | Y1Q_0009388 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa) |
| | YWHAQ | 14-3-3 protein theta; Belongs to the 14-3-3 family. (267 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1443 aa) |
| | RFC2 | Replication factor C subunit 2. (340 aa) |
| | YWHAG | 14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | YWHAH | 14-3-3 protein eta; Belongs to the 14-3-3 family. (247 aa) |
| | RFC5 | Replication factor C subunit 5. (336 aa) |
| | CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12. (441 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform A. (516 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2. (75 aa) |
| | Y1Q_0005128 | Proteasome subunit beta. (277 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component 1. (229 aa) |
| | Y1Q_0004667 | Uncharacterized protein. (92 aa) |
| | YWHAZ | 14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (319 aa) |
| | Y1Q_0017935 | Reverse transcriptase domain-containing protein. (228 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (253 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | Y1Q_0014292 | Piezo_RRas_bdg domain-containing protein. (81 aa) |
| | Y1Q_0020715 | Piezo_RRas_bdg domain-containing protein. (220 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa) |
| | ORC3 | Origin recognition complex subunit 3 isoform A. (713 aa) |
| | BLM | Bloom syndrome protein. (1213 aa) |
| | ORC6 | Origin recognition complex subunit 6. (267 aa) |
| | RPA3 | Replication protein A subunit. (120 aa) |
| | CNTD2 | Cyclin N-terminal domain-containing protein 2; Belongs to the cyclin family. (232 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (257 aa) |
| | FAM38B | Piezo-type mechanosensitive ion channel component 2. (797 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169 isoform B. (626 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (696 aa) |
| | SLF1 | Ankyrin repeat domain-containing protein 32. (825 aa) |
| | ANKRD31-1 | Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa) |
| | WDR41 | WD repeat-containing protein 41. (459 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B1 isoform B; Belongs to the cyclin family. (411 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | CLSPN | Claspin. (1316 aa) |
| | RBBP8-1 | DNA endonuclease RBBP8 isoform B. (936 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | BABAM1 | BRISC and BRCA1-A complex member 1. (325 aa) |
| | PKMYT1 | Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (554 aa) |
| | Y1Q_0012805 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | PSMC6 | 26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa) |
| | Y1Q_0014479 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | Y1Q_0018383 | Histone H2B-like; Belongs to the histone H2B family. (152 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (549 aa) |
| | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11. (518 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (284 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein. (832 aa) |
| | ATRIP | ATR-interacting protein. (672 aa) |
| | NSD2 | Uncharacterized protein. (1370 aa) |
| | PSMC1 | 26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36. (261 aa) |
| | CCNB3 | G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (435 aa) |
| | Y1Q_0014681 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3063 aa) |
| | RHNO1 | RAD9. (261 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (521 aa) |
| | ANKRD11 | Ankyrin repeat domain-containing protein 11. (2899 aa) |
| | CTNNA3 | Catenin alpha-3. (157 aa) |
| | CMTR1-1 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (521 aa) |
| | Y1Q_0007301 | Piezo-type mechanosensitive ion channel component 1-like. (506 aa) |
| | BRE | BRCA1-A complex subunit BRE. (398 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1514 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit. (273 aa) |
| | Y1Q_0016180 | Uncharacterized protein. (89 aa) |
| | MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa) |
| | Y1Q_0012919 | Uncharacterized protein. (87 aa) |
| | Y1Q_0018179 | PIEZO domain-containing protein. (254 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa) |
| | YWHAB | 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (300 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2510 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13. (376 aa) |
| | PIAS4 | E3 SUMO-protein ligase PIAS4. (541 aa) |
| | PSMB6 | Proteasome subunit beta. (227 aa) |
| | Y1Q_0000043 | Uncharacterized protein. (73 aa) |
| | Y1Q_0006757 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa) |
| | HIST1H4D | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | CDC45 | Cell division control 45-like protein. (501 aa) |
| | RAD9B-1 | Cell cycle checkpoint control protein RAD9B isoform B. (364 aa) |
| | SCARB1 | Scavenger receptor class B member 1 isoform A. (959 aa) |
| | PSMD9-1 | 26S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa) |
| | PSMB5 | Proteasome subunit beta type-5. (211 aa) |
| | PSMB11 | Proteasome subunit beta. (261 aa) |
| | PSMC2 | 26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa) |
| | MCM10 | MCM10-like protein. (868 aa) |
| | ORC5 | Origin recognition complex subunit 5. (420 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (861 aa) |
| | Y1Q_0003907 | MCM domain-containing protein. (120 aa) |
| | Y1Q_0003896 | Reverse transcriptase domain-containing protein. (253 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (144 aa) |
| | PSMB9 | Proteasome subunit beta. (216 aa) |
| | PSMB8 | Proteasome subunit beta. (282 aa) |
| | YWHAE | 14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | TP53BP1-1 | Tumor suppressor p53-binding protein 1 isoform A. (2124 aa) |
| | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6. (348 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (589 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (888 aa) |
| | TM4SF19 | Transmembrane 4 L6 family member 19. (205 aa) |
| | CDK2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | TDRD3 | Tudor domain-containing protein 3 isoform A. (743 aa) |
| | RCBTB1-2 | BTB domain-containing protein. (595 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (566 aa) |
| | EXO1 | Exonuclease 1. (775 aa) |
| | MCM8 | DNA helicase MCM8; Belongs to the MCM family. (795 aa) |
| | RPS27A | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | PSME4 | Proteasome activator complex subunit 4. (1808 aa) |
| | PSMB7 | Proteasome subunit beta. (274 aa) |
| | PSMD5-1 | 26S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa) |
| | Y1Q_0003135 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa) |
| | WEE1 | Wee1-like protein kinase. (1114 aa) |
| | PSMA1 | Proteasome subunit alpha type. (261 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2 isoform A. (621 aa) |
| | PSMC3 | 26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa) |
| | CCNB2 | G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa) |
| | Y1Q_0001599 | Reverse transcriptase domain-containing protein. (173 aa) |
| | HYKK | Proteasome endopeptidase complex. (600 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1. (524 aa) |
| | RAD50 | DNA repair protein RAD50. (1448 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa) |
| | CDC7-1 | Cell division cycle 7-related protein kinase isoform B. (672 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (949 aa) |
| | 44G24.1 | Histone H2B.3; Belongs to the histone H2B family. (142 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa) |
| | MCM9L | DNA helicase MCM9. (752 aa) |
| | MCM9 | DNA helicase MCM9; Belongs to the MCM family. (463 aa) |
| | PSMA3 | Proteasome subunit alpha type. (256 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (822 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (460 aa) |
| | Y1Q_0015745 | Uncharacterized protein. (257 aa) |
| | HIST1H2BF | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HIST2H2BE | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Y1Q_0020100 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | Y1Q_0020098 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N. (112 aa) |
| | Y1Q_0022362 | Histone H2B.3-like. (135 aa) |
| | GTSE1 | G2 and S phase-expressed protein 1. (747 aa) |
| | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7. (322 aa) |
