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KXD1 KXD1 ZNF385B ZNF385B PSMD14 PSMD14 PSMA3 PSMA3 PSMB4 PSMB4 PSMD4 PSMD4 HYKK HYKK MDM4 MDM4 PSMC3 PSMC3 PSMA1 PSMA1 CDKN1C CDKN1C PSMD5-1 PSMD5-1 PSMB7 PSMB7 PSME4 PSME4 RPS27A RPS27A RFWD2 RFWD2 CDK2 CDK2 PSMD6 PSMD6 PSMB8 PSMB8 PSMB9 PSMB9 CCNA1-1 CCNA1-1 ZNF385D-2 ZNF385D-2 TP53 TP53 CCNE2-1 CCNE2-1 PSMD1 PSMD1 Y1Q_0005128 Y1Q_0005128 PSMD12 PSMD12 CDK3 CDK3 CCNE1 CCNE1 CDKN1A CDKN1A PSMA5 PSMA5 PSMC5 PSMC5 PSMC4 PSMC4 PSMA6 PSMA6 PSME2 PSME2 PSME1 PSME1 PSMD10 PSMD10 PSMD7 PSMD7 PSMC2 PSMC2 PSMB11 PSMB11 PSMB5 PSMB5 PSMD9-1 PSMD9-1 SCARB1 SCARB1 PSMB6 PSMB6 PSMD13 PSMD13 PSMA7 PSMA7 PSMF1 PSMF1 PSMD3 PSMD3 PSMB3 PSMB3 CDKN1B CDKN1B CDKN1D CDKN1D ATM ATM PSMC1 PSMC1 PSMD11 PSMD11 ZNF385C-1 ZNF385C-1 PSMC6 PSMC6 CCNA2 CCNA2 MDM2 MDM2 PSMB2 PSMB2 Y1Q_0010122 Y1Q_0010122 PSMD8 PSMD8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KXD1KxDL motif-containing protein 1. (293 aa)
ZNF385BZinc finger protein 385B isoform B. (505 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (460 aa)
PSMA3Proteasome subunit alpha type. (256 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa)
HYKKProteasome endopeptidase complex. (600 aa)
MDM4Protein Mdm4. (513 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
PSMA1Proteasome subunit alpha type. (261 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (223 aa)
PSMD5-126S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa)
PSMB7Proteasome subunit beta. (274 aa)
PSME4Proteasome activator complex subunit 4. (1808 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
RFWD2E3 ubiquitin-protein ligase RFWD2 isoform A. (796 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (348 aa)
PSMB8Proteasome subunit beta. (282 aa)
PSMB9Proteasome subunit beta. (216 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
ZNF385D-2U1-type domain-containing protein. (92 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
CCNE2-1G1/S-specific cyclin-E2 isoform B; Belongs to the cyclin family. (410 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
Y1Q_0005128Proteasome subunit beta. (277 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (441 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (408 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (232 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
PSME1Proteasome activator complex subunit 1. (150 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMB11Proteasome subunit beta. (261 aa)
PSMB5Proteasome subunit beta type-5. (211 aa)
PSMD9-126S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
PSMB6Proteasome subunit beta. (227 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMF1Proteasome inhibitor PI31 subunit. (273 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (521 aa)
PSMB3Proteasome subunit beta. (205 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (131 aa)
CDKN1DCyclin-dependent kinase inhibitor 1D. (153 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (518 aa)
ZNF385C-1Zinc finger protein 385C isoform A. (1099 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
PSMB2Proteasome subunit beta. (201 aa)
Y1Q_0010122Uncharacterized protein. (300 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (257 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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