STRINGSTRING
RECQL4 RECQL4 NUDC-1 NUDC-1 Y1Q_0016099 Y1Q_0016099 RANGAP1 RANGAP1 WEE2-1 WEE2-1 NUP37 NUP37 MCM5 MCM5 CENPM CENPM PSMC4 PSMC4 CHEK1 CHEK1 CDCA8 CDCA8 PIEZO2-2 PIEZO2-2 SEH1L SEH1L ANKRD12 ANKRD12 NDC80 NDC80 Y1Q_0001015 Y1Q_0001015 BIRC5 BIRC5 MCM3 MCM3 CENPQ-1 CENPQ-1 ATR ATR BARD1 BARD1 BIRC5B BIRC5B ORC2 ORC2 SGOL2 SGOL2 PSMC5 PSMC5 PSMA5 PSMA5 Y1Q_0008603 Y1Q_0008603 CDKN1A CDKN1A Y1Q_0009388 Y1Q_0009388 YWHAQ YWHAQ DYNC1LI2 DYNC1LI2 CCNE1 CCNE1 CLIP2 CLIP2 MIS12 MIS12 DYNLL2 DYNLL2 PAFAH1B1 PAFAH1B1 WRN WRN RFC2 RFC2 YWHAG YWHAG PPP2CB PPP2CB DYNLL1 DYNLL1 YWHAH YWHAH RFC5 RFC5 CDK3 CDK3 NUP85 NUP85 PSMD12 PSMD12 MEIOB MEIOB TOP3A TOP3A MAD1L1 MAD1L1 RMI2 RMI2 NDE1 NDE1 Y1Q_0005128 Y1Q_0005128 PSMD1 PSMD1 PIEZO1 PIEZO1 ANAPC10 ANAPC10 Y1Q_0004667 Y1Q_0004667 CCNE2-1 CCNE2-1 YWHAZ YWHAZ Y1Q_0017935 Y1Q_0017935 CDC20B-1 CDC20B-1 Y1Q_0009945 Y1Q_0009945 CENPK CENPK RAD1 RAD1 SKA1-1 SKA1-1 TP53 TP53 Y1Q_0014292 Y1Q_0014292 Y1Q_0020715 Y1Q_0020715 BUB1B BUB1B CASC5 CASC5 CDK1 CDK1 PPP2R5B PPP2R5B RAD9A RAD9A ORC3 ORC3 BLM BLM MTUS2-1 MTUS2-1 ORC6 ORC6 MAPRE3-1 MAPRE3-1 DYNC1LI1 DYNC1LI1 ZNF385D-2 ZNF385D-2 SGOL1 SGOL1 RPA3 RPA3 DYNC1I1 DYNC1I1 CNTD2 CNTD2 CCNA1-1 CCNA1-1 RFC3 RFC3 MCM4 MCM4 Y1Q_0003907 Y1Q_0003907 Y1Q_0003896 Y1Q_0003896 MAPRE2 MAPRE2 UBE2V2 UBE2V2 NUP160 NUP160 CKAP5 CKAP5 PSMB9 PSMB9 PSMB8 PSMB8 YWHAE YWHAE TP53BP1-1 TP53BP1-1 PSMD6 PSMD6 SEC13 SEC13 RNF168 RNF168 MCM2 MCM2 TM4SF19 TM4SF19 RCC2 RCC2 CENPC CENPC Y1Q_0002109 Y1Q_0002109 CDK2 CDK2 NUF2 NUF2 CENPL CENPL RFWD2 RFWD2 MAPRE1 MAPRE1 CDC23 CDC23 TDRD3 TDRD3 RCBTB1-2 RCBTB1-2 RCBTB1 RCBTB1 AHCTF1 AHCTF1 EXO1 EXO1 MCM8 MCM8 XPO1 XPO1 RPS27A RPS27A PSME4 PSME4 UBE2S UBE2S PSMB7 PSMB7 PSMD5-1 PSMD5-1 CDC26 CDC26 ANAPC2 ANAPC2 Y1Q_0003135 Y1Q_0003135 PPP2R5D PPP2R5D PPP2R1A PPP2R1A CDKN1C CDKN1C WEE1 WEE1 PSMA1 PSMA1 KIF18A KIF18A EXD2 EXD2 CKAP5-2 CKAP5-2 PSMC3 PSMC3 MDM4 MDM4 CCNB2 CCNB2 Y1Q_0001599 Y1Q_0001599 HYKK HYKK ZWILCH ZWILCH RMI1 RMI1 ERCC6L2 ERCC6L2 RAD50 RAD50 PPP2CA PPP2CA RFC4 RFC4 PSMD4 PSMD4 PSMB4 PSMB4 CDC7-1 CDC7-1 ORC1 ORC1 MCM9L MCM9L MCM9 MCM9 NUP133 NUP133 PPP2R5E PPP2R5E PSMA3 PSMA3 BUB1 BUB1 ANAPC1 ANAPC1 NUP98 NUP98 CLASP1 CLASP1 MCM6 MCM6 ORC4 ORC4 PSMD14 PSMD14 DYNC1I2 DYNC1I2 SPC25 SPC25 ZNF385B ZNF385B Y1Q_0015745 Y1Q_0015745 HIST1H2BF HIST1H2BF HIST2H2BE HIST2H2BE Y1Q_0020100 Y1Q_0020100 Y1Q_0020098 Y1Q_0020098 UBE2N UBE2N Y1Q_0022362 Y1Q_0022362 44G24.1 44G24.1 RPA1 RPA1 ANAPC15 ANAPC15 PSMD8 PSMD8 FAM38B FAM38B RNF169 RNF169 RAD17 RAD17 SLF1 SLF1 ANKRD31-1 ANKRD31-1 CENPH CENPH WDR41 WDR41 Y1Q_0010122 Y1Q_0010122 CCNB1 CCNB1 MCM7 MCM7 CLSPN CLSPN RBBP8-1 RBBP8-1 PSMB2 PSMB2 BABAM1 BABAM1 UBE2C UBE2C MDM2 MDM2 NUP107 NUP107 CCNA2 CCNA2 MAD2L1 MAD2L1 PKMYT1 PKMYT1 Y1Q_0012805 Y1Q_0012805 PSMC6 PSMC6 Y1Q_0014479 Y1Q_0014479 ZNF385C-1 ZNF385C-1 Y1Q_0018383 Y1Q_0018383 CDC6 CDC6 PSMD11 PSMD11 HUS1 HUS1 CDC27 CDC27 KIF2C KIF2C BRCA1 BRCA1 CENPPL CENPPL CENPP CENPP ATRIP ATRIP ANAPC4 ANAPC4 NSD2 NSD2 PSMC1 PSMC1 PPP2R5C-2 PPP2R5C-2 BRCC3 BRCC3 DYNC1H1 DYNC1H1 CCNB3 CCNB3 Y1Q_0014681 Y1Q_0014681 ERCC6L ERCC6L ATM ATM CDKN1D CDKN1D CDKN1B CDKN1B RHNO1 RHNO1 CDC20 CDC20 PSMB3 PSMB3 PSMD3 PSMD3 ANKRD11 ANKRD11 CENPF CENPF BUB3 BUB3 GLTSCR1-1 GLTSCR1-1 CTNNA3 CTNNA3 CMTR1-1 CMTR1-1 PPP2R5C PPP2R5C NSL1 NSL1 Y1Q_0007301 Y1Q_0007301 BRE BRE TOPBP1 TOPBP1 CLASP2 CLASP2 PSMF1 PSMF1 Y1Q_0016180 Y1Q_0016180 MRE11A MRE11A Y1Q_0012919 Y1Q_0012919 Y1Q_0018179 Y1Q_0018179 CENPO CENPO DNA2 DNA2 ZW10 ZW10 ANAPC16 ANAPC16 YWHAB YWHAB PIEZO2 PIEZO2 PSMA7 PSMA7 INCENPL INCENPL NNF1 NNF1 INCENP INCENP PSMD13 PSMD13 RANBP2 RANBP2 CDC16 CDC16 PLK1 PLK1 PIAS4 PIAS4 DSN1 DSN1 NDEL1 NDEL1 KXD1 KXD1 PSMB6 PSMB6 Y1Q_0000043 Y1Q_0000043 KNTC1 KNTC1 Y1Q_0006757 Y1Q_0006757 HIST1H4D HIST1H4D CLIP1 CLIP1 CDC45 CDC45 RAD9B-1 RAD9B-1 SCARB1 SCARB1 ANAPC5 ANAPC5 ANAPC7 ANAPC7 PSMD9-1 PSMD9-1 ANAPC11 ANAPC11 SPDL1 SPDL1 PSMB5 PSMB5 ZWINT ZWINT PSMB11 PSMB11 PSMC2 PSMC2 MCM10 MCM10 ORC5 ORC5 GTSE1 GTSE1 PSMD7 PSMD7 HIST1H2B5L HIST1H2B5L PSMD10 PSMD10 CENPI CENPI CENPN CENPN PSME1 PSME1 PSME2 PSME2 NUP43 NUP43 SPC24 SPC24 SFN SFN CHEK2 CHEK2 PSMA6 PSMA6 ITGB3BP ITGB3BP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RECQL4ATP-dependent DNA helicase Q4 isoform A. (1385 aa)
NUDC-1Nuclear migration protein nudC isoform A. (346 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
RANGAP1Ran GTPase-activating protein 1. (568 aa)
WEE2-1Wee1-like protein kinase. (592 aa)
NUP37Nucleoporin Nup37. (341 aa)
MCM5DNA helicase; Belongs to the MCM family. (773 aa)
CENPMCentromere protein M. (177 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
CDCA8Borealin. (234 aa)
PIEZO2-2Piezo-type mechanosensitive ion channel component. (2595 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (360 aa)
ANKRD12Ankyrin repeat domain-containing protein 12. (761 aa)
NDC80Kinetochore NDC80-like protein. (639 aa)
Y1Q_0001015Reverse transcriptase domain-containing protein. (170 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (140 aa)
MCM3DNA helicase; Belongs to the MCM family. (772 aa)
CENPQ-1Centromere protein Q isoform A. (220 aa)
ATRSerine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa)
BARD1BRCA1-associated RING domain protein 1 isoform B. (792 aa)
BIRC5BBaculoviral IAP repeat-containing 5b. (171 aa)
ORC2Origin recognition complex subunit 2. (569 aa)
SGOL2Shugoshin-like 2. (356 aa)
PSMC5Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family. (411 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
Y1Q_0008603Uncharacterized protein. (483 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (232 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (267 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (489 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (408 aa)
CLIP2Uncharacterized protein. (1015 aa)
MIS12MIS12-like protein. (188 aa)
DYNLL2Dynein light chain. (77 aa)
PAFAH1B1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
WRNWerner syndrome ATP-dependent helicase. (1443 aa)
RFC2Replication factor C subunit 2. (340 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
DYNLL1Dynein light chain. (123 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (247 aa)
RFC5Replication factor C subunit 5. (336 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (348 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (620 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (441 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform A. (516 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform B. (1005 aa)
RMI2RecQ-mediated genome instability protein 2. (75 aa)
NDE1Nuclear distribution nudE-like protein 1. (323 aa)
Y1Q_0005128Proteasome subunit beta. (277 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
PIEZO1Piezo-type mechanosensitive ion channel component 1. (229 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (179 aa)
Y1Q_0004667Uncharacterized protein. (92 aa)
CCNE2-1G1/S-specific cyclin-E2 isoform B; Belongs to the cyclin family. (410 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (319 aa)
Y1Q_0017935Reverse transcriptase domain-containing protein. (228 aa)
CDC20B-1Cell division cycle 20-like protein B isoform A. (555 aa)
Y1Q_0009945Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (744 aa)
CENPKCentromere protein K. (290 aa)
RAD1Cell cycle checkpoint protein RAD1. (253 aa)
SKA1-1Spindle and kinetochore-associated protein 1 isoform A. (315 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
Y1Q_0014292Piezo_RRas_bdg domain-containing protein. (81 aa)
Y1Q_0020715Piezo_RRas_bdg domain-containing protein. (220 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (997 aa)
CASC5Protein CASC5 isoform A. (2158 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
PPP2R5BSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (493 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa)
ORC3Origin recognition complex subunit 3 isoform A. (713 aa)
BLMBloom syndrome protein. (1213 aa)
MTUS2-1Microtubule-associated tumor suppressor candidate 2-like isoform A. (1045 aa)
ORC6Origin recognition complex subunit 6. (267 aa)
MAPRE3-1Microtubule-associated protein RP/EB family member 3 isoform B. (338 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (532 aa)
ZNF385D-2U1-type domain-containing protein. (92 aa)
SGOL1Shugoshin-like 1 isoform A. (447 aa)
RPA3Replication protein A subunit. (120 aa)
DYNC1I1WD_REPEATS_REGION domain-containing protein. (675 aa)
CNTD2Cyclin N-terminal domain-containing protein 2; Belongs to the cyclin family. (232 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
RFC3Replication factor C subunit 3. (356 aa)
MCM4DNA helicase; Belongs to the MCM family. (861 aa)
Y1Q_0003907MCM domain-containing protein. (120 aa)
Y1Q_0003896Reverse transcriptase domain-containing protein. (253 aa)
MAPRE2Microtubule-associated protein RP/EB family member 2. (325 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (144 aa)
NUP160Nuclear pore complex protein Nup160. (1373 aa)
CKAP5Cytoskeleton-associated protein 5. (1360 aa)
PSMB9Proteasome subunit beta. (216 aa)
PSMB8Proteasome subunit beta. (282 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
TP53BP1-1Tumor suppressor p53-binding protein 1 isoform A. (2124 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (348 aa)
SEC13SEC13-like protein; Belongs to the WD repeat SEC13 family. (320 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (589 aa)
MCM2DNA helicase; Belongs to the MCM family. (888 aa)
TM4SF19Transmembrane 4 L6 family member 19. (205 aa)
RCC2Protein RCC2. (435 aa)
CENPCCentromere protein C. (613 aa)
Y1Q_0002109Uncharacterized protein. (179 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
NUF2Kinetochore protein Nuf2. (553 aa)
CENPLCentromere protein L isoform A. (341 aa)
RFWD2E3 ubiquitin-protein ligase RFWD2 isoform A. (796 aa)
MAPRE1Microtubule-associated protein RP/EB family member 1. (286 aa)
CDC23Cell division cycle 23-like protein isoform B. (585 aa)
TDRD3Tudor domain-containing protein 3 isoform A. (743 aa)
RCBTB1-2BTB domain-containing protein. (595 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (566 aa)
AHCTF1Protein ELYS. (1901 aa)
EXO1Exonuclease 1. (775 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (795 aa)
XPO1Exportin-1. (1001 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
PSME4Proteasome activator complex subunit 4. (1808 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (215 aa)
PSMB7Proteasome subunit beta. (274 aa)
PSMD5-126S proteasome non-ATPase regulatory subunit 5 isoform B. (837 aa)
CDC26Anaphase-promoting complex subunit CDC26. (84 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (675 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
PPP2R5DSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (596 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform. (643 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (223 aa)
WEE1Wee1-like protein kinase. (1114 aa)
PSMA1Proteasome subunit alpha type. (261 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2 isoform A. (621 aa)
CKAP5-2Uncharacterized protein. (2029 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (404 aa)
MDM4Protein Mdm4. (513 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
Y1Q_0001599Reverse transcriptase domain-containing protein. (173 aa)
HYKKProteasome endopeptidase complex. (600 aa)
ZWILCHZwilch-like protein. (568 aa)
RMI1RecQ-mediated genome instability protein 1. (524 aa)
ERCC6L2DNA excision repair protein ERCC-6-like 2. (1396 aa)
RAD50DNA repair protein RAD50. (1448 aa)
PPP2CASerine/threonine-protein phosphatase; Belongs to the SKP1 family. (474 aa)
RFC4Replication factor C subunit 4. (364 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform A. (381 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (281 aa)
CDC7-1Cell division cycle 7-related protein kinase isoform B. (672 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (949 aa)
MCM9LDNA helicase MCM9. (752 aa)
MCM9DNA helicase MCM9; Belongs to the MCM family. (463 aa)
NUP133Nuclear pore complex protein Nup133. (1154 aa)
PPP2R5ESerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (515 aa)
PSMA3Proteasome subunit alpha type. (256 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1. (1069 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1942 aa)
NUP98Nuclear pore complex protein Nup98-Nup96 isoform A. (1816 aa)
CLASP1CLIP-associating protein 1 isoform B. (1464 aa)
MCM6DNA helicase; Belongs to the MCM family. (822 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (460 aa)
DYNC1I2Cytoplasmic dynein 1 intermediate chain 2 isoform C. (726 aa)
SPC25Kinetochore protein Spc25. (269 aa)
ZNF385BZinc finger protein 385B isoform B. (505 aa)
Y1Q_0015745Uncharacterized protein. (257 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
UBE2NUbiquitin-conjugating enzyme E2 N. (112 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (584 aa)
ANAPC15Anaphase-promoting complex subunit 15. (94 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (257 aa)
FAM38BPiezo-type mechanosensitive ion channel component 2. (797 aa)
RNF169E3 ubiquitin-protein ligase RNF169 isoform B. (626 aa)
RAD17Cell cycle checkpoint protein RAD17. (696 aa)
SLF1Ankyrin repeat domain-containing protein 32. (825 aa)
ANKRD31-1Putative ankyrin repeat domain-containing protein 31 isoform C. (1142 aa)
CENPHCentromere protein H. (240 aa)
WDR41WD repeat-containing protein 41. (459 aa)
Y1Q_0010122Uncharacterized protein. (300 aa)
CCNB1G2/mitotic-specific cyclin-B1 isoform B; Belongs to the cyclin family. (411 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CLSPNClaspin. (1316 aa)
RBBP8-1DNA endonuclease RBBP8 isoform B. (936 aa)
PSMB2Proteasome subunit beta. (201 aa)
BABAM1BRISC and BRCA1-A complex member 1. (325 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (859 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
PKMYT1Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (554 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
ZNF385C-1Zinc finger protein 385C isoform A. (1099 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (549 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (518 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
CDC27Cell division cycle 27-like protein. (834 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (740 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
CENPPLCentromere protein P. (82 aa)
CENPPCentromere protein P. (150 aa)
ATRIPATR-interacting protein. (672 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (796 aa)
NSD2Uncharacterized protein. (1370 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
PPP2R5C-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (602 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (261 aa)
DYNC1H1Uncharacterized protein. (4633 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (435 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
ERCC6LDNA excision repair protein ERCC-6-like. (694 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
CDKN1DCyclin-dependent kinase inhibitor 1D. (153 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (131 aa)
RHNO1RAD9. (261 aa)
CDC20Cell division cycle 20-like protein. (427 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (521 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2899 aa)
CENPFCentromere protein F. (2477 aa)
BUB3Mitotic checkpoint protein BUB3. (384 aa)
GLTSCR1-1Glioma tumor suppressor candidate region 1 protein isoform C. (1814 aa)
CTNNA3Catenin alpha-3. (157 aa)
CMTR1-1E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (521 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (479 aa)
NSL1Kinetochore-associated NSL1-like protein. (274 aa)
Y1Q_0007301Piezo-type mechanosensitive ion channel component 1-like. (506 aa)
BREBRCA1-A complex subunit BRE. (398 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1514 aa)
CLASP2Uncharacterized protein. (1568 aa)
PSMF1Proteasome inhibitor PI31 subunit. (273 aa)
Y1Q_0016180Uncharacterized protein. (89 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
Y1Q_0012919Uncharacterized protein. (87 aa)
Y1Q_0018179PIEZO domain-containing protein. (254 aa)
CENPOCentromere protein O. (351 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa)
ZW10Centromere/kinetochore zw10-like protein. (751 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (300 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2510 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
INCENPLInner centromere protein-like isoform D. (1075 aa)
NNF1Nnf1 protein. (197 aa)
INCENPInner centromere protein isoform A. (888 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
RANBP2E3 SUMO-protein ligase RanBP2. (2133 aa)
CDC16Cell division cycle 16-like protein. (622 aa)
PLK1Serine/threonine-protein kinase PLK. (664 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (541 aa)
DSN1Kinetochore-associated DSN1-like protein. (350 aa)
NDEL1Nuclear distribution protein nudE-like 1. (369 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
PSMB6Proteasome subunit beta. (227 aa)
Y1Q_0000043Uncharacterized protein. (73 aa)
KNTC1Kinetochore-associated protein 1. (2218 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CLIP1CAP-Gly domain-containing linker protein 1 isoform A. (1893 aa)
CDC45Cell division control 45-like protein. (501 aa)
RAD9B-1Cell cycle checkpoint control protein RAD9B isoform B. (364 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
ANAPC5Anaphase-promoting complex subunit 5. (756 aa)
ANAPC7Anaphase-promoting complex subunit 7. (608 aa)
PSMD9-126S proteasome non-ATPase regulatory subunit 9 isoform B. (205 aa)
ANAPC11Anaphase-promoting complex subunit 11. (98 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (626 aa)
PSMB5Proteasome subunit beta type-5. (211 aa)
ZWINTZW10 interactor. (352 aa)
PSMB11Proteasome subunit beta. (261 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
MCM10MCM10-like protein. (868 aa)
ORC5Origin recognition complex subunit 5. (420 aa)
GTSE1G2 and S phase-expressed protein 1. (747 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
CENPICentromere protein I. (736 aa)
CENPNCentromere protein N. (347 aa)
PSME1Proteasome activator complex subunit 1. (150 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
NUP43Nucleoporin Nup43. (379 aa)
SPC24Kinetochore protein Spc24. (207 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (246 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform B. (433 aa)
PSMA6Proteasome subunit alpha type. (252 aa)
ITGB3BPCentromere protein R. (181 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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