STRINGSTRING
POLR2E POLR2E GATAD2B GATAD2B CCNH CCNH GTF2H2 GTF2H2 CDK7 CDK7 Y1Q_0012805 Y1Q_0012805 Y1Q_0014479 Y1Q_0014479 PTRF PTRF Y1Q_0018383 Y1Q_0018383 UBTF UBTF POLR1A POLR1A Y1Q_0014681 Y1Q_0014681 MTA1 MTA1 TAF1A-1 TAF1A-1 TAF1D TAF1D POLR2L-1 POLR2L-1 AIRE AIRE GTF2H1 GTF2H1 POLR1B POLR1B CHD3 CHD3 Y1Q_0003135 Y1Q_0003135 TTF1 TTF1 POLR1C POLR1C ERCC6 ERCC6 GATAD2A GATAD2A RBBP4-2 RBBP4-2 TWISTNB TWISTNB CBX3 CBX3 MBD2 MBD2 ERCC2 ERCC2 CD3EAP CD3EAP TAF1C TAF1C RBBP4 RBBP4 RRN3 RRN3 CHD5 CHD5 MNAT1 MNAT1 CHD3-2 CHD3-2 TAF1B TAF1B Y1Q_0009388 Y1Q_0009388 POLR1E POLR1E MBD3 MBD3 POLR2F POLR2F Y1Q_0016099 Y1Q_0016099 POLR2L-2 POLR2L-2 H2AFZ H2AFZ HIST1H2B5L HIST1H2B5L H2AFV H2AFV DMTF1 DMTF1 GTF2H3 GTF2H3 MTA1-2 MTA1-2 ACRC-1 ACRC-1 HIST1H4D HIST1H4D Y1Q_0006757 Y1Q_0006757 GTF2H4 GTF2H4 ZNRD1 ZNRD1 POLR2H POLR2H MTA2 MTA2 TBPL1 TBPL1 TBP TBP GTF2H5 GTF2H5 TBPL2 TBPL2 ERCC3 ERCC3 HIST1H2BF HIST1H2BF HIST2H2BE HIST2H2BE Y1Q_0020100 Y1Q_0020100 Y1Q_0020098 Y1Q_0020098 Y1Q_0022362 Y1Q_0022362 44G24.1 44G24.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR2EDNA-directed RNA polymerases I, II, and III subunit RPABC1. (231 aa)
GATAD2BTranscriptional repressor p66-beta isoform B. (634 aa)
CCNHCyclin-H; Belongs to the cyclin family. (247 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
Y1Q_0012805Histone H2B; Belongs to the histone H2B family. (118 aa)
Y1Q_0014479Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa)
PTRFPolymerase I and transcript release factor. (360 aa)
Y1Q_0018383Histone H2B-like; Belongs to the histone H2B family. (152 aa)
UBTFNucleolar transcription factor 1 isoform B. (711 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1689 aa)
Y1Q_0014681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (119 aa)
MTA1Metastasis-associated protein MTA1. (590 aa)
TAF1A-1TATA box-binding protein-associated factor RNA polymerase I subunit A isoform B. (454 aa)
TAF1DTATA box-binding protein-associated factor RNA polymerase I subunit D. (330 aa)
POLR2L-1DNA-directed RNA polymerases I, II, and III subunit RPABC5. (104 aa)
AIREAutoimmune regulator isoform B. (519 aa)
GTF2H1L-lactate dehydrogenase. (910 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1078 aa)
CHD3Chromodomain-helicase-DNA-binding protein 3. (1920 aa)
Y1Q_0003135Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
TTF1Transcription termination factor 1. (476 aa)
POLR1CDNA-directed RNA polymerases I and III subunit RPAC1. (346 aa)
ERCC6DNA excision repair protein ERCC-6. (1491 aa)
GATAD2ATranscriptional repressor p66-alpha isoform C. (621 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
TWISTNBDNA-directed RNA polymerase I subunit RPA43. (317 aa)
CBX3Chromobox protein-like protein 3. (173 aa)
MBD2Methyl-CpG-binding domain protein 2. (222 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
CD3EAPDNA-directed RNA polymerase I subunit RPA34. (226 aa)
TAF1CTATA box-binding protein-associated factor RNA polymerase I subunit C. (117 aa)
RBBP4Histone-binding protein RBBP4. (424 aa)
RRN3RNA polymerase I-specific transcription initiation factor RRN3. (617 aa)
CHD5Uncharacterized protein. (1864 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CHD3-2Uncharacterized protein. (1966 aa)
TAF1BTATA box-binding protein-associated factor RNA polymerase I subunit B. (592 aa)
Y1Q_0009388Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
POLR1EDNA-directed RNA polymerase I subunit RPA49. (417 aa)
MBD3Methyl-CpG-binding domain protein 3. (329 aa)
POLR2FDNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
Y1Q_0016099Histone H2B; Belongs to the histone H2B family. (126 aa)
POLR2L-2DNA-directed RNA polymerases I, II, and III subunit RPABC5. (74 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AFVHistone H2A; Belongs to the histone H2A family. (128 aa)
DMTF1Cyclin-D-binding Myb-like transcription factor 1 isoform B. (804 aa)
GTF2H3General transcription factor IIH subunit 3. (328 aa)
MTA1-2Uncharacterized protein. (694 aa)
ACRC-1Acidic repeat-containing protein isoform B. (498 aa)
HIST1H4DHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
Y1Q_0006757Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (111 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (404 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (121 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (161 aa)
MTA2Uncharacterized protein. (676 aa)
TBPL1TATA box-binding protein-like protein 1. (255 aa)
TBPTATA-box-binding protein. (301 aa)
GTF2H5General transcription factor IIH subunit 5. (115 aa)
TBPL2TATA box-binding protein-like protein 2. (331 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (779 aa)
HIST1H2BFHistone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0020100Histone H2B; Belongs to the histone H2B family. (126 aa)
Y1Q_0020098Histone H2B; Belongs to the histone H2B family. (166 aa)
Y1Q_0022362Histone H2B.3-like. (135 aa)
44G24.1Histone H2B.3; Belongs to the histone H2B family. (142 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.