STRINGSTRING
Y1Q_0004038 Y1Q_0004038 TGFBR1 TGFBR1 CHRDL2 CHRDL2 SMAD4 SMAD4 STUB1 STUB1 SMAD6 SMAD6 DRAP1 DRAP1 ITGB3 ITGB3 ACVR1-2 ACVR1-2 Y1Q_0011595 Y1Q_0011595 ACVR2A ACVR2A CCNT2 CCNT2 ITGB5 ITGB5 TGFBR2 TGFBR2 INHBB INHBB ZFYVE9 ZFYVE9 Y1Q_0022110 Y1Q_0022110 Y1Q_0022112 Y1Q_0022112 Y1Q_0022111 Y1Q_0022111 FAM58A FAM58A CGN CGN SNW1 SNW1 SMAD2 SMAD2 MEIS3 MEIS3 NEDD8 NEDD8 SMAD3 SMAD3 FBN1 FBN1 RNF111-1 RNF111-1 FSTL1 FSTL1 CDK9 CDK9 SKIL SKIL RPS27A RPS27A MEIS1 MEIS1 LTBP2 LTBP2 GREM2 GREM2 GDF2 GDF2 TGFB3 TGFB3 SMAD5 SMAD5 F11R F11R ITGB8-1 ITGB8-1 TGFBR2-2 TGFBR2-2 ACVR1C ACVR1C ACVR1 ACVR1 IRX5 IRX5 IRX6-1 IRX6-1 IRX3 IRX3 BMPR1A-2 BMPR1A-2 CCNT1 CCNT1 MEIS2 MEIS2 Y1Q_0009747 Y1Q_0009747 SMAD2-2 SMAD2-2 SMAD7 SMAD7 FST FST SMURF1 SMURF1 NOG NOG SMURF2 SMURF2 SKI SKI Y1Q_0018253 Y1Q_0018253 PCSK4 PCSK4 PCSK4-2 PCSK4-2 NOG2 NOG2 MEN1 MEN1 BMPR2 BMPR2 Y1Q_0008635 Y1Q_0008635 Y1Q_0008637 Y1Q_0008637 ITGAV-2 ITGAV-2 PARD3B PARD3B TFDP2 TFDP2 NCOR1 NCOR1 IRX4 IRX4 IRX1 IRX1 IRX2 IRX2 TGIF1 TGIF1 Y1Q_0016705 Y1Q_0016705 LDLRAD4 LDLRAD4 AMH AMH STRAP STRAP PARD6A PARD6A LTBP2-2 LTBP2-2 LTBP3 LTBP3 BMPR1A BMPR1A CHRDL1 CHRDL1 ATP1B4 ATP1B4 USP9X USP9X Y1Q_0018673 Y1Q_0018673 SCARB1 SCARB1 CCNC CCNC MTMR4 MTMR4 KXD1 KXD1 LTBP4 LTBP4 ARHGEF28 ARHGEF28 PMEPA1-1 PMEPA1-1 Y1Q_0002693 Y1Q_0002693 Y1Q_0022523 Y1Q_0022523 JUNB JUNB TGFB1 TGFB1 TGIF2 TGIF2 FSTL3 FSTL3 Y1Q_0017506 Y1Q_0017506 PARP1 PARP1 TGFB2 TGFB2 UBE2M UBE2M FOXH1 FOXH1 Y1Q_0020693 Y1Q_0020693 SP1 SP1 AMHR2 AMHR2 BMP10 BMP10 CCNK CCNK ZCCHC4 ZCCHC4 SMAD1 SMAD1 ITGB3-2 ITGB3-2 MKX MKX BAMBI BAMBI PARD3 PARD3 ACVR2B ACVR2B E2F5 E2F5 Y1Q_0022650 Y1Q_0022650
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y1Q_0004038Zinc finger FYVE domain-containing protein. (1340 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
CHRDL2Chordin-like protein 2. (435 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
STUB1E3 ubiquitin-protein ligase CHIP isoform A. (339 aa)
SMAD6Mothers against decapentaplegic homolog. (265 aa)
DRAP1Dr1-associated corepressor. (219 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
ACVR1-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
Y1Q_0011595Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (498 aa)
CCNT2Cyclin-T2 isoform B; Belongs to the cyclin family. (351 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
INHBBUncharacterized protein. (132 aa)
ZFYVE9Zinc finger FYVE domain-containing protein 9. (721 aa)
Y1Q_0022110Uncharacterized protein. (113 aa)
Y1Q_0022112Uncharacterized protein. (79 aa)
Y1Q_0022111Uncharacterized protein. (81 aa)
FAM58ACyclin-related protein FAM58A; Belongs to the cyclin family. (231 aa)
CGNCingulin isoform A. (1295 aa)
SNW1SNW domain-containing protein 1. (536 aa)
SMAD2Mothers against decapentaplegic homolog. (474 aa)
MEIS3Homeobox protein Meis3 isoform B. (398 aa)
NEDD8NEDD8. (79 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
FBN1Uncharacterized protein. (2939 aa)
RNF111-1E3 ubiquitin-protein ligase Arkadia isoform A. (911 aa)
FSTL1Follistatin-related protein 1. (258 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (418 aa)
SKILSki-like protein. (336 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
MEIS1Homeobox protein Meis1. (470 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2 isoform A. (1616 aa)
GREM2Gremlin-2. (167 aa)
GDF2Growth/differentiation factor 2. (430 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
SMAD5Mothers against decapentaplegic homolog. (490 aa)
F11RJunctional adhesion molecule A. (310 aa)
ITGB8-1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TGFBR2-2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
IRX5Iroquois-class homeodomain protein IRX-5. (487 aa)
IRX6-1Iroquois-class homeodomain protein IRX-6 isoform A. (504 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (246 aa)
BMPR1A-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (600 aa)
CCNT1Cyclin-T1; Belongs to the cyclin family. (592 aa)
MEIS2Homeobox domain-containing protein. (415 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
SMAD2-2Mothers against decapentaplegic homolog. (512 aa)
SMAD7Mothers against decapentaplegic homolog. (384 aa)
FSTFollistatin. (343 aa)
SMURF1E3 ubiquitin-protein ligase. (732 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
SMURF2E3 ubiquitin-protein ligase. (786 aa)
SKISki oncogene isoform A. (637 aa)
Y1Q_0018253Uncharacterized protein; Belongs to the peptidase S8 family. (460 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4. (578 aa)
PCSK4-2Uncharacterized protein. (188 aa)
NOG2Noggin; Belongs to the noggin family. (214 aa)
MEN1Menin. (456 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
Y1Q_0008635Par3_HAL_N_term domain-containing protein. (198 aa)
Y1Q_0008637Uncharacterized protein. (521 aa)
ITGAV-2Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
PARD3BPartitioning defective 3-like protein B. (796 aa)
TFDP2Transcription factor. (447 aa)
NCOR1Nuclear receptor corepressor 1 isoform B. (2411 aa)
IRX4Iroquois-class homeodomain protein IRX-4. (449 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (307 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (321 aa)
TGIF1Homeobox protein TGIF1. (268 aa)
Y1Q_0016705Mothers against decapentaplegic-like protein 6-like. (215 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4. (310 aa)
AMHMuellerian-inhibiting factor. (629 aa)
STRAPSerine-threonine kinase receptor-associated protein. (350 aa)
PARD6APartitioning defective 6-like protein alpha. (367 aa)
LTBP2-2Uncharacterized protein. (1551 aa)
LTBP3Uncharacterized protein. (620 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CHRDL1Chordin-like protein 1 isoform B. (456 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (321 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2552 aa)
Y1Q_0018673Uncharacterized protein. (2454 aa)
SCARB1Scavenger receptor class B member 1 isoform A. (959 aa)
CCNCCyclin-C; Belongs to the cyclin family. (283 aa)
MTMR4Myotubularin-related protein 4 isoform A. (1123 aa)
KXD1KxDL motif-containing protein 1. (293 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4. (1231 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform B. (1520 aa)
PMEPA1-1Protein TMEPAI isoform B. (238 aa)
Y1Q_0002693Uncharacterized protein. (87 aa)
Y1Q_0022523Uncharacterized protein. (291 aa)
JUNBTranscription factor jun-B. (292 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
TGIF2Homeobox protein TGIF2. (295 aa)
FSTL3Follistatin-related protein 3. (249 aa)
Y1Q_0017506TGF_BETA_2 domain-containing protein. (424 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
UBE2MNEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
FOXH1Forkhead box protein H1. (310 aa)
Y1Q_0020693Forkhead box protein H1. (75 aa)
SP1Transcription factor Sp1. (746 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (497 aa)
BMP10Bone morphogenetic protein 10. (426 aa)
CCNKCyclin-K; Belongs to the cyclin family. (585 aa)
ZCCHC4Zinc finger CCHC domain-containing protein 4. (502 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
MKXHomeobox protein Mohawk. (352 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
PARD3Partitioning defective 3-like protein isoform A. (1225 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
E2F5Transcription factor E2F5. (386 aa)
Y1Q_0022650Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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