STRINGSTRING
AKT2 AKT2 GNG4 GNG4 AKT3 AKT3 ESR2 ESR2 Y1Q_0003573 Y1Q_0003573 KRAS-2 KRAS-2 KRAS-1 KRAS-1 STRN3-2 STRN3-2 ESR1 ESR1 ZDHHC7 ZDHHC7 HBEGF-1 HBEGF-1 UHMK1 UHMK1 STRN4 STRN4 Y1Q_0006325 Y1Q_0006325 GNG8 GNG8 ZDHHC21 ZDHHC21 TGFA TGFA PRMT1 PRMT1 MMP7 MMP7 Y1Q_0017424 Y1Q_0017424 CAV2 CAV2 CAV1 CAV1 Y1Q_0003612 Y1Q_0003612 NRAS NRAS GNB4 GNB4 GNB3 GNB3 XPO1 XPO1 AKT3-2 AKT3-2 STRN3 STRN3 WDR64 WDR64 PDPK1 PDPK1 CAV3 CAV3 MMP9 MMP9 Y1Q_0018542 Y1Q_0018542 PIK3R1-2 PIK3R1-2 ELK1 ELK1 PRMT1-2 PRMT1-2 GNG13 GNG13 GNG2 GNG2 BTC BTC EREG EREG EPGN EPGN HSPB1 HSPB1 PIK3R1 PIK3R1 CREB1 CREB1 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase. (270 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (87 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ESR2Estrogen receptor beta. (406 aa)
Y1Q_0003573SH3 domain-containing protein. (167 aa)
KRAS-2GTPase KRas. (219 aa)
KRAS-1GTPase KRas. (215 aa)
STRN3-2WD_REPEATS_REGION domain-containing protein. (712 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (261 aa)
HBEGF-1Proheparin-binding EGF-like growth factor isoform B. (205 aa)
UHMK1Serine/threonine-protein kinase Kist. (386 aa)
STRN4WD_REPEATS_REGION domain-containing protein. (563 aa)
Y1Q_0006325Uncharacterized protein. (188 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (155 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (325 aa)
TGFAProtransforming growth factor alpha. (159 aa)
PRMT1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (379 aa)
MMP7Matrilysin. (229 aa)
Y1Q_0017424Uncharacterized protein. (235 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (158 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
Y1Q_0003612Rho-GAP domain-containing protein. (189 aa)
NRASGTPase NRas. (189 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
GNB3WD_REPEATS_REGION domain-containing protein. (340 aa)
XPO1Exportin-1. (1001 aa)
AKT3-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
STRN3Striatin-3 isoform B. (784 aa)
WDR64WD repeat-containing protein 64. (1106 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (515 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MMP9Uncharacterized protein. (684 aa)
Y1Q_0018542Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
PIK3R1-2Uncharacterized protein. (750 aa)
ELK1ETS domain-containing protein Elk-1. (396 aa)
PRMT1-2Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (391 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (228 aa)
BTCProbetacellulin. (170 aa)
EREGProepiregulin. (159 aa)
EPGNEpigen isoform B. (150 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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