25 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR3C2	Mineralocorticoid receptor isoform A. (1022 aa)
	ACE	Angiotensin-converting enzyme. (1244 aa)
	CASP14-2	Uncharacterized protein; Belongs to the peptidase C14A family. (249 aa)
	DPP4	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (757 aa)
	DPP4-2	Uncharacterized protein; Belongs to the peptidase S9B family. (992 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (474 aa)
	BDNF	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (246 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (147 aa)
	GHRL-1	Appetite-regulating hormone isoform B. (145 aa)
	NPY	Pro-neuropeptide Y isoform A. (161 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	HIF1A	Uncharacterized protein. (747 aa)
	CASP18	Initiator caspase; Belongs to the peptidase C14A family. (424 aa)
	CASP8-1	Caspase-8 isoform B; Belongs to the peptidase C14A family. (462 aa)
	MC4R	Melanocortin receptor 4. (331 aa)
	PRL	Prolactin. (236 aa)
	OPN4	Opsin 4xa. (553 aa)
	SCT	Secretin. (141 aa)
	SIRT3-1	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
	INSR-2	Tyrosine-protein kinase receptor. (1352 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (634 aa)
	GLP1R	Glucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (438 aa)
	NTF3-1	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (319 aa)
	APLN	Apelin. (70 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (292 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	A0A151PC80	A0A151N089	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.433
ACE	AGT	A0A151PC80	A0A151M2N2	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.968
ACE	DPP4-2	A0A151PC80	A0A151M0D2	Angiotensin-converting enzyme.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.540
ACE	INS	A0A151PC80	A0A151MCB0	Angiotensin-converting enzyme.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.504
ACE	NR3C2	A0A151PC80	A0A151PB58	Angiotensin-converting enzyme.	Mineralocorticoid receptor isoform A.	0.560
ACE2	ACE	A0A151N089	A0A151PC80	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.433
ACE2	AGT	A0A151N089	A0A151M2N2	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.924
ACE2	DPP4	A0A151N089	A0A151M0A4	Angiotensin-converting enzyme.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.708
ACE2	DPP4-2	A0A151N089	A0A151M0D2	Angiotensin-converting enzyme.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.790
ACE2	INS	A0A151N089	A0A151MCB0	Angiotensin-converting enzyme.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.404
AGT	ACE	A0A151M2N2	A0A151PC80	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.968
AGT	ACE2	A0A151M2N2	A0A151N089	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.924
AGT	DPP4	A0A151M2N2	A0A151M0A4	Angiotensinogen; Belongs to the serpin family.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.456
AGT	DPP4-2	A0A151M2N2	A0A151M0D2	Angiotensinogen; Belongs to the serpin family.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.472
AGT	GHRL-1	A0A151M2N2	A0A151MK48	Angiotensinogen; Belongs to the serpin family.	Appetite-regulating hormone isoform B.	0.565
AGT	NPY	A0A151M2N2	A0A151MQK1	Angiotensinogen; Belongs to the serpin family.	Pro-neuropeptide Y isoform A.	0.469
AGT	NR3C2	A0A151M2N2	A0A151PB58	Angiotensinogen; Belongs to the serpin family.	Mineralocorticoid receptor isoform A.	0.724
APLN	GHRL-1	A0A151P8B7	A0A151MK48	Apelin.	Appetite-regulating hormone isoform B.	0.487
APLN	NPY	A0A151P8B7	A0A151MQK1	Apelin.	Pro-neuropeptide Y isoform A.	0.756
BDNF	INS	A0A151MBN4	A0A151MCB0	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.538