STRINGSTRING
ETS1 ETS1 CHD8 CHD8 RUNX1 RUNX1 STAT1 STAT1 KDM5B KDM5B MYCN MYCN DDX17 DDX17 MAFK MAFK RELA RELA TP53 TP53 EOMES EOMES EGR1 EGR1 RUNX1-2 RUNX1-2 SPI1 SPI1 TBP TBP OTX2 OTX2 NFE2L2 NFE2L2 NR1H3 NR1H3 PPARG PPARG GATA6 GATA6 KMT2D KMT2D BRCA1 BRCA1 YAP1 YAP1 PGR-1 PGR-1 E2F1 E2F1 TRIM28 TRIM28 CEBPB CEBPB TAF1 TAF1 GATA3 GATA3 ZBTB33 ZBTB33 ESR1 ESR1 KMT2D-2 KMT2D-2 CREBBP CREBBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ETS1Protein C-ets-1 isoform B. (540 aa)
CHD8Uncharacterized protein. (2136 aa)
RUNX1Runt-related transcription factor. (398 aa)
STAT1Signal transducer and activator of transcription. (753 aa)
KDM5BLysine-specific demethylase 5B isoform A. (1519 aa)
MYCNN-myc proto-oncogene protein. (248 aa)
DDX17Putative ATP-dependent RNA helicase DDX17 isoform B; Belongs to the DEAD box helicase family. (605 aa)
MAFKTranscription factor MafK. (188 aa)
RELATranscription factor p65. (350 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
EOMESEomesodermin-like protein isoform B. (404 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (429 aa)
RUNX1-2Runt domain-containing protein. (486 aa)
SPI1Transcription factor PU.1. (266 aa)
TBPTATA-box-binding protein. (301 aa)
OTX2Homeobox protein OTX2. (373 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (482 aa)
NR1H3Oxysterols receptor LXR-alpha. (408 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (453 aa)
GATA6Transcription factor GATA-6. (325 aa)
KMT2DHistone-lysine N-methyltransferase 2D isoform C. (4340 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
YAP1Transcriptional coactivator YAP1 isoform A. (432 aa)
PGR-1Progesterone receptor isoform B. (408 aa)
E2F1Transcription factor E2F1. (426 aa)
TRIM28Transcription intermediary factor 1-beta isoform C. (823 aa)
CEBPBCCAAT/enhancer-binding protein beta. (141 aa)
TAF1Transcription initiation factor TFIID subunit. (1966 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
ZBTB33Transcriptional regulator Kaiso. (702 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
KMT2D-2Uncharacterized protein. (2572 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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