24 items (Alligator mississippiensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	ITCH	E3 ubiquitin-protein ligase. (894 aa)
	TLR2A	Toll-like receptor 2 type-1; Belongs to the Toll-like receptor family. (801 aa)
	IFITM3	Uncharacterized protein. (66 aa)
	IRF7	Interferon regulatory factor 7. (605 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
	ITCH-2	E3 ubiquitin-protein ligase. (832 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (292 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (677 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (125 aa)
	WWP1	E3 ubiquitin-protein ligase. (946 aa)
	IRF3	Interferon regulatory factor 3 isoform B. (462 aa)
	CASP14-2	Uncharacterized protein; Belongs to the peptidase C14A family. (249 aa)
	EEA1	Early endosome antigen 1. (1428 aa)
	TANK	TRAF family member-associated NF-kappa-B activator. (472 aa)
	EIF4A3-2	Uncharacterized protein; Belongs to the DEAD box helicase family. (409 aa)
	NEDD4L	E3 ubiquitin-protein ligase. (887 aa)
	CASP9	Caspase-9; Belongs to the peptidase C14A family. (423 aa)
	Y1Q_0019264	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (129 aa)
	MAVS	Mitochondrial antiviral-signaling protein. (768 aa)
	TFRC	Transferrin receptor protein 1. (779 aa)
	DDX54	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (806 aa)
	NRP2-2	Neuropilin; Belongs to the neuropilin family. (942 aa)
	CD63	Tetraspanin. (240 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP14-2	CASP3	A0A151LY53	A0A151PAW5	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase-3; Belongs to the peptidase C14A family.	0.900
CASP14-2	CASP9	A0A151LY53	A0A151MJ40	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase-9; Belongs to the peptidase C14A family.	0.987
CASP14-2	IFNG	A0A151LY53	A0A151PFH4	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.457
CASP14-2	Y1Q_0019264	A0A151LY53	A0A151MQK6	Uncharacterized protein; Belongs to the peptidase C14A family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.894
CASP3	CASP14-2	A0A151PAW5	A0A151LY53	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.900
CASP3	CASP9	A0A151PAW5	A0A151MJ40	Caspase-3; Belongs to the peptidase C14A family.	Caspase-9; Belongs to the peptidase C14A family.	0.985
CASP3	IFNG	A0A151PAW5	A0A151PFH4	Caspase-3; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.456
CASP3	Y1Q_0019264	A0A151PAW5	A0A151MQK6	Caspase-3; Belongs to the peptidase C14A family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.893
CASP9	CASP14-2	A0A151MJ40	A0A151LY53	Caspase-9; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.987
CASP9	CASP3	A0A151MJ40	A0A151PAW5	Caspase-9; Belongs to the peptidase C14A family.	Caspase-3; Belongs to the peptidase C14A family.	0.985
CASP9	Y1Q_0019264	A0A151MJ40	A0A151MQK6	Caspase-9; Belongs to the peptidase C14A family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.998
CD63	EEA1	A0A151NL05	A0A151LYR9	Tetraspanin.	Early endosome antigen 1.	0.598
DDX54	EIF4E	A0A151N5A2	A0A151NMP7	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.461
DDX54	EIF4E1B	A0A151N5A2	A0A151NYG2	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Eukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family.	0.641
DDX54	TANK	A0A151N5A2	A0A151M0A1	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	TRAF family member-associated NF-kappa-B activator.	0.463
EEA1	CD63	A0A151LYR9	A0A151NL05	Early endosome antigen 1.	Tetraspanin.	0.598
EEA1	TFRC	A0A151LYR9	A0A151MZF9	Early endosome antigen 1.	Transferrin receptor protein 1.	0.586
EIF4A3-2	EIF4E	A0A151M1I6	A0A151NMP7	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.854
EIF4A3-2	EIF4E1B	A0A151M1I6	A0A151NYG2	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family.	0.805
EIF4E	DDX54	A0A151NMP7	A0A151N5A2	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.461