STRINGSTRING
H6PD H6PD c-jun c-jun PPARG PPARG RPS23 RPS23 FH FH LGSN LGSN CRYGN CRYGN KLF6 KLF6 RPS8 RPS8 NR3C2 NR3C2 RPLP1 RPLP1 CRYL1 CRYL1 KLF8 KLF8 KLF8L KLF8L RPS11 RPS11 YBX3 YBX3 NFE2L1 NFE2L1 TGFB2 TGFB2 RPS6 RPS6 HMBS HMBS RPS10 RPS10 BASP1 BASP1 RPL38 RPL38 ISYNA1 ISYNA1 ACTB ACTB HSF5 HSF5 CRYBB2 CRYBB2 CRYBA2 CRYBA2 RPL8 RPL8 NFAT5 NFAT5 MAF MAF SPARCL1 SPARCL1 POU4F1 POU4F1 LDHB LDHB NFIA NFIA CRYZ CRYZ CRYGS CRYGS NFIB NFIB CUX1-2 CUX1-2 CUX1 CUX1 RPLP0 RPLP0 GSTT1 GSTT1 PAX6 PAX6 RPS2 RPS2 CRYM CRYM TUBB TUBB TFRC TFRC YWHAZ YWHAZ KLF10 KLF10 CRYBB1 CRYBB1 CRYBA4 CRYBA4 EEF1A2 EEF1A2 BACH2 BACH2 CREB5 CREB5 HOXA10 HOXA10 DESMB DESMB SMAD5 SMAD5 NKX6-3 NKX6-3 RPS20 RPS20 PABPC1 PABPC1 TGFB3 TGFB3 ARIH1 ARIH1 NR2C2 NR2C2 CD24 CD24 HADH HADH BFSP1 BFSP1 CRYZL1 CRYZL1 GAPDH GAPDH TBP TBP GLIS1 GLIS1 FOXE3 FOXE3 RPL5 RPL5 MSX2 MSX2 NR3C1 NR3C1 RPL4 RPL4 B2M B2M
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H6PDGDH/6PGL endoplasmic bifunctional protein. (715 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (453 aa)
RPS2340S ribosomal protein S23 isoform A; Belongs to the universal ribosomal protein uS12 family. (143 aa)
FHSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (1165 aa)
LGSNLengsin; Belongs to the glutamine synthetase family. (439 aa)
CRYGNGamma-crystallin N; Belongs to the beta/gamma-crystallin family. (177 aa)
KLF6Krueppel-like factor 6. (283 aa)
RPS840S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
NR3C2Mineralocorticoid receptor isoform A. (1022 aa)
RPLP160S acidic ribosomal protein P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
CRYL1Lambda-crystallin-like protein. (324 aa)
KLF8Krueppel-like factor 8. (363 aa)
KLF8LKrueppel-like factor 5. (451 aa)
RPS1140S ribosomal protein S11 isoform A; Belongs to the universal ribosomal protein uS17 family. (158 aa)
YBX3Y-box-binding protein 3. (221 aa)
NFE2L1Nuclear factor erythroid 2-related factor 1. (876 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
HMBSPorphobilinogen deaminase isoform A. (346 aa)
RPS1040S ribosomal protein S10. (195 aa)
BASP1Brain acid soluble protein 1. (244 aa)
RPL3860S ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
ISYNA1Inositol-3-phosphate synthase 1. (557 aa)
ACTBUncharacterized protein. (400 aa)
HSF5Heat shock factor protein 5. (527 aa)
CRYBB2Beta-crystallin B2; Belongs to the beta/gamma-crystallin family. (204 aa)
CRYBA2Beta-crystallin A2; Belongs to the beta/gamma-crystallin family. (208 aa)
RPL860S ribosomal protein L8. (267 aa)
NFAT5Nuclear factor of activated T-cells 5 isoform A. (858 aa)
MAFTranscription factor Maf; Belongs to the bZIP family. (278 aa)
SPARCL1SPARC-like protein 1. (694 aa)
POU4F1POU domain protein. (193 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (375 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (509 aa)
CRYZQuinone oxidoreductase. (367 aa)
CRYGSBeta-crystallin S; Belongs to the beta/gamma-crystallin family. (182 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (511 aa)
CUX1-2Homeobox protein cut-like 1. (350 aa)
CUX1Protein CASP isoform B. (781 aa)
RPLP060S acidic ribosomal protein P0. (367 aa)
GSTT1Glutathione S-transferase theta-1; Belongs to the GST superfamily. (261 aa)
PAX6Paired box protein Pax-6. (516 aa)
RPS240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (221 aa)
CRYMKetimine reductase mu-crystallin. (314 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
TFRCTransferrin receptor protein 1. (779 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (319 aa)
KLF10Krueppel-like factor 10. (121 aa)
CRYBB1Beta-crystallin B1; Belongs to the beta/gamma-crystallin family. (238 aa)
CRYBA4Beta-crystallin A4 isoform A; Belongs to the beta/gamma-crystallin family. (351 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (469 aa)
BACH2Transcription regulator protein BACH2. (605 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (552 aa)
HOXA10Homeobox protein Hox-A10. (265 aa)
DESMBDesmin; Belongs to the intermediate filament family. (388 aa)
SMAD5Mothers against decapentaplegic homolog. (490 aa)
NKX6-3Homeobox protein Nkx-6.3. (203 aa)
RPS2040S ribosomal protein S20. (119 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (617 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
ARIH1RBR-type E3 ubiquitin transferase. (445 aa)
NR2C2Nuclear receptor subfamily 2 group C member 2. (629 aa)
CD24CD24 molecule. (84 aa)
HADHHydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (277 aa)
BFSP1Filensin; Belongs to the intermediate filament family. (657 aa)
CRYZL1Quinone oxidoreductase-like protein 1. (349 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TBPTATA-box-binding protein. (301 aa)
GLIS1Zinc finger protein GLIS1 isoform B. (784 aa)
FOXE3Forkhead box protein E3. (211 aa)
RPL560S ribosomal protein L5. (317 aa)
MSX2Homeobox protein MSX-2. (255 aa)
NR3C1Glucocorticoid receptor. (742 aa)
RPL460S ribosomal protein L4. (363 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (116 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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