(21 nodes) Other glycan degradation network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLB1	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family. (569 aa)
	MAN2C1	Alpha-mannosidase 2C1. (1018 aa)
	NEU4	Sialidase-4. (532 aa)
	HEXB	Beta-hexosaminidase. (531 aa)
	NEU1	Sialidase-1. (242 aa)
	FUCA1	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (452 aa)
	GBA2	Non-lysosomal glucosylceramidase. (597 aa)
	ENGASE	Cytosolic endo-beta-N-acetylglucosaminidase. (922 aa)
	HEXDC	Hexosaminidase D. (472 aa)
	GBA	Glucosylceramidase. (779 aa)
	MAN2B1	Alpha-mannosidase. (985 aa)
	Y1Q_0020688	Glucosylceramidase. (347 aa)
	FUCA2	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (453 aa)
	MANBA	Beta-mannosidase; Belongs to the ubiquitin-conjugating enzyme family. (1003 aa)
	NEU2	Sialidase-2. (423 aa)
	HEXDCL	Hexosaminidase D. (661 aa)
	GLB1-2	Beta-galactosidase. (651 aa)
	MAN2B2	Alpha-mannosidase. (1006 aa)
	AGA	N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform A. (349 aa)
	HEXB-2	Uncharacterized protein. (441 aa)
	NEU3	Sialidase-3. (451 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENGASE	MAN2C1	A0A151MVP5	A0A151M9V6	Cytosolic endo-beta-N-acetylglucosaminidase.	Alpha-mannosidase 2C1.	0.692
FUCA1	FUCA2	A0A151MMN0	A0A151NLT5	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	0.909
FUCA1	GLB1	A0A151MMN0	A0A151LY90	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	0.511
FUCA1	GLB1-2	A0A151MMN0	A0A151P2K4	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Beta-galactosidase.	0.514
FUCA1	HEXDC	A0A151MMN0	A0A151N357	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Hexosaminidase D.	0.495
FUCA2	FUCA1	A0A151NLT5	A0A151MMN0	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	0.909
FUCA2	GLB1	A0A151NLT5	A0A151LY90	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	0.522
FUCA2	GLB1-2	A0A151NLT5	A0A151P2K4	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	Beta-galactosidase.	0.524
GBA	GBA2	A0A151N939	A0A151MRU9	Glucosylceramidase.	Non-lysosomal glucosylceramidase.	0.924
GBA	GLB1	A0A151N939	A0A151LY90	Glucosylceramidase.	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	0.950
GBA	GLB1-2	A0A151N939	A0A151P2K4	Glucosylceramidase.	Beta-galactosidase.	0.950
GBA	Y1Q_0020688	A0A151N939	A0A151NGN7	Glucosylceramidase.	Glucosylceramidase.	0.901
GBA2	GBA	A0A151MRU9	A0A151N939	Non-lysosomal glucosylceramidase.	Glucosylceramidase.	0.924
GBA2	GLB1	A0A151MRU9	A0A151LY90	Non-lysosomal glucosylceramidase.	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	0.908
GBA2	GLB1-2	A0A151MRU9	A0A151P2K4	Non-lysosomal glucosylceramidase.	Beta-galactosidase.	0.908
GBA2	Y1Q_0020688	A0A151MRU9	A0A151NGN7	Non-lysosomal glucosylceramidase.	Glucosylceramidase.	0.924
GLB1	FUCA1	A0A151LY90	A0A151MMN0	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	0.511
GLB1	FUCA2	A0A151LY90	A0A151NLT5	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.	0.522
GLB1	GBA	A0A151LY90	A0A151N939	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	Glucosylceramidase.	0.950
GLB1	GBA2	A0A151LY90	A0A151MRU9	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	Non-lysosomal glucosylceramidase.	0.908