(22 nodes) Glycosaminoglycan degradation network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLB1	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family. (569 aa)
	HYAL1	Hyaluronidase. (445 aa)
	HYAL2	Hyaluronidase. (474 aa)
	HYAL3-1	Hyaluronidase. (644 aa)
	HGSNAT	Heparan-alpha-glucosaminide N-acetyltransferase isoform A. (627 aa)
	HEXB	Beta-hexosaminidase. (531 aa)
	BMS1-2	Heparan-alpha-glucosaminide N-acetyltransferase-like. (496 aa)
	GALNS	N-acetylgalactosamine-6-sulfatase. (505 aa)
	GUSB	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (644 aa)
	IDS	Iduronate 2-sulfatase. (545 aa)
	NAGLU	Alpha-N-acetylglucosaminidase. (620 aa)
	IDUA	Alpha-L-iduronidase. (549 aa)
	SGSH	N-sulfoglucosamine sulfohydrolase. (415 aa)
	HPSE	Heparanase. (529 aa)
	GLB1-2	Beta-galactosidase. (651 aa)
	HPSE2-1	Inactive heparanase-2. (324 aa)
	HYAL6	Hyaluronidase. (454 aa)
	HYAL4	Hyaluronidase. (507 aa)
	SPAM1-1	Hyaluronidase. (464 aa)
	GNS	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (531 aa)
	HEXB-2	Uncharacterized protein. (441 aa)
	ARSB	Arylsulfatase B. (379 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	GNS	A0A151PHR7	A0A151PFF3	Arylsulfatase B.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.611
ARSB	HYAL1	A0A151PHR7	A0A151MEI0	Arylsulfatase B.	Hyaluronidase.	0.903
ARSB	HYAL2	A0A151PHR7	A0A151MEK7	Arylsulfatase B.	Hyaluronidase.	0.904
ARSB	HYAL3-1	A0A151PHR7	A0A151MEL0	Arylsulfatase B.	Hyaluronidase.	0.904
ARSB	HYAL4	A0A151PHR7	A0A151PEL8	Arylsulfatase B.	Hyaluronidase.	0.905
ARSB	HYAL6	A0A151PHR7	A0A151PEJ9	Arylsulfatase B.	Hyaluronidase.	0.903
ARSB	IDS	A0A151PHR7	A0A151N7T7	Arylsulfatase B.	Iduronate 2-sulfatase.	0.563
ARSB	IDUA	A0A151PHR7	A0A151NES5	Arylsulfatase B.	Alpha-L-iduronidase.	0.913
ARSB	SPAM1-1	A0A151PHR7	A0A151PF17	Arylsulfatase B.	Hyaluronidase.	0.905
BMS1-2	GNS	A0A151MT48	A0A151PFF3	Heparan-alpha-glucosaminide N-acetyltransferase-like.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.413
BMS1-2	HGSNAT	A0A151MT48	A0A151MIW6	Heparan-alpha-glucosaminide N-acetyltransferase-like.	Heparan-alpha-glucosaminide N-acetyltransferase isoform A.	0.902
BMS1-2	NAGLU	A0A151MT48	A0A151N9V1	Heparan-alpha-glucosaminide N-acetyltransferase-like.	Alpha-N-acetylglucosaminidase.	0.948
BMS1-2	SGSH	A0A151MT48	A0A151NLH1	Heparan-alpha-glucosaminide N-acetyltransferase-like.	N-sulfoglucosamine sulfohydrolase.	0.931
GALNS	GLB1	A0A151MUY5	A0A151LY90	N-acetylgalactosamine-6-sulfatase.	Beta-galactosidase; Belongs to the glycosyl hydrolase 35 family.	0.955
GALNS	GLB1-2	A0A151MUY5	A0A151P2K4	N-acetylgalactosamine-6-sulfatase.	Beta-galactosidase.	0.955
GALNS	GNS	A0A151MUY5	A0A151PFF3	N-acetylgalactosamine-6-sulfatase.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.425
GALNS	GUSB	A0A151MUY5	A0A151N6D5	N-acetylgalactosamine-6-sulfatase.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.544
GALNS	HGSNAT	A0A151MUY5	A0A151MIW6	N-acetylgalactosamine-6-sulfatase.	Heparan-alpha-glucosaminide N-acetyltransferase isoform A.	0.424
GALNS	NAGLU	A0A151MUY5	A0A151N9V1	N-acetylgalactosamine-6-sulfatase.	Alpha-N-acetylglucosaminidase.	0.485
GALNS	SGSH	A0A151MUY5	A0A151NLH1	N-acetylgalactosamine-6-sulfatase.	N-sulfoglucosamine sulfohydrolase.	0.552