68 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOS1-2	Son of sevenless-like protein. (1379 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PAK2	Non-specific serine/threonine protein kinase. (546 aa)
	PIK3CB-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	MAPK9	Mitogen-activated protein kinase. (430 aa)
	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform B; Belongs to the protein kinase superfamily. (489 aa)
	GAB1	GRB2-associated-binding protein 1 isoform A. (720 aa)
	SHC2L	SHC-transforming protein 2 isoform A. (632 aa)
	MAP2K1-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	NRG4	Pro-neuregulin-4, membrane-bound. (115 aa)
	GSK3B-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
	CBLB-2	Uncharacterized protein. (995 aa)
	ABL1-2	Tyrosine-protein kinase. (1139 aa)
	PAK7	Serine/threonine-protein kinase PAK 7 isoform B. (671 aa)
	AKT3-2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ABL1	Tyrosine-protein kinase. (665 aa)
	PAK2-2	Non-specific serine/threonine protein kinase. (741 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	CRK	Adapter molecule crk. (291 aa)
	Y1Q_0013899	Uncharacterized protein. (103 aa)
	AKT2	Non-specific serine/threonine protein kinase. (270 aa)
	NRG3	Pro-neuregulin-3, membrane-bound isoform isoform A. (353 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (475 aa)
	PAK6	Non-specific serine/threonine protein kinase. (688 aa)
	ERBB3	Protein kinase domain-containing protein. (1303 aa)
	PIK3R1-2	Uncharacterized protein. (750 aa)
	PRKCA	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	SOS1-1	Son of sevenless-like protein 1 isoform A. (1305 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
	BTC	Probetacellulin. (170 aa)
	EREG	Proepiregulin. (159 aa)
	RPS6KB1-2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (232 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1335 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1. (112 aa)
	NRG1-1	Pro-neuregulin-1, membrane-bound isoform C. (636 aa)
	CBLB	E3 ubiquitin-protein ligase CBL-B. (526 aa)
	BRAF-2	Uncharacterized protein. (791 aa)
	KRAS-1	GTPase KRas. (215 aa)
	PAPL	Non-specific serine/threonine protein kinase. (383 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1237 aa)
	PAK3	Non-specific serine/threonine protein kinase. (526 aa)
	SHC1	SHC-transforming protein 1. (421 aa)
	HBEGF-1	Proheparin-binding EGF-like growth factor isoform B. (205 aa)
	NRG2-2	Uncharacterized protein. (261 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
	Y1Q_0020451	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
	NCK2	Cytoplasmic protein NCK2. (301 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (377 aa)
	SRC-2	Tyrosine-protein kinase. (546 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1282 aa)
	SHC2	SHC-transforming protein 2. (550 aa)
	EGFR	Uncharacterized protein. (633 aa)
	TGFA	Protransforming growth factor alpha. (159 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1262 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (633 aa)
	CDKN1D	Cyclin-dependent kinase inhibitor 1D. (153 aa)
	PTK2	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
	Y1Q_0014732	Phosphoinositide phospholipase C. (1335 aa)
	STAT5B	Signal transducer and activator of transcription 5B isoform B. (593 aa)
	NRAS	GTPase NRas. (189 aa)
	BRAF	Serine/threonine-protein kinase B-raf. (651 aa)
	c-jun	Transcription factor AP-1; Belongs to the bZIP family. (320 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL1-2	A0A151MIR6	A0A151MFN4	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
ABL1	CBLB	A0A151MIR6	A0A151NGT1	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL-B.	0.486
ABL1	CBLB-2	A0A151MIR6	A0A151MDD0	Tyrosine-protein kinase.	Uncharacterized protein.	0.486
ABL1	CRK	A0A151MIR6	A0A151MLC9	Tyrosine-protein kinase.	Adapter molecule crk.	0.987
ABL1	EGFR	A0A151MIR6	A0A151P2I6	Tyrosine-protein kinase.	Uncharacterized protein.	0.555
ABL1	GRB2	A0A151MIR6	A0A151N2T8	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.699
ABL1	MAP2K1	A0A151MIR6	A0A151NXN5	Tyrosine-protein kinase.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.423
ABL1	MAP2K1-2	A0A151MIR6	A0A151M8Y0	Tyrosine-protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.420
ABL1	MAPK1	A0A151MIR6	A0A151NRL4	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.411
ABL1	NCK2	A0A151MIR6	A0A151NWX0	Tyrosine-protein kinase.	Cytoplasmic protein NCK2.	0.497
ABL1	PIK3R1	A0A151MIR6	A0A151N8Y8	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.456
ABL1	Y1Q_0013899	A0A151MIR6	A0A151MP93	Tyrosine-protein kinase.	Uncharacterized protein.	0.411
ABL1	Y1Q_0020451	A0A151MIR6	A0A151NTV5	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.411
ABL1-2	ABL1	A0A151MFN4	A0A151MIR6	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.901
ABL1-2	CBLB	A0A151MFN4	A0A151NGT1	Tyrosine-protein kinase.	E3 ubiquitin-protein ligase CBL-B.	0.486
ABL1-2	CBLB-2	A0A151MFN4	A0A151MDD0	Tyrosine-protein kinase.	Uncharacterized protein.	0.486
ABL1-2	CRK	A0A151MFN4	A0A151MLC9	Tyrosine-protein kinase.	Adapter molecule crk.	0.987
ABL1-2	GRB2	A0A151MFN4	A0A151N2T8	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.699
ABL1-2	MAP2K1	A0A151MFN4	A0A151NXN5	Tyrosine-protein kinase.	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.424
ABL1-2	MAP2K1-2	A0A151MFN4	A0A151M8Y0	Tyrosine-protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.420