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CALM1 CALM1 DGKA-2 DGKA-2 SYNJ2 SYNJ2 TMEM55B TMEM55B CDS2 CDS2 PI4KBL PI4KBL PIK3CB-2 PIK3CB-2 PIK3CB PIK3CB INPP4A INPP4A PIP5K1B PIP5K1B CALML4 CALML4 PIK3C2B PIK3C2B DGKZ DGKZ PIK3C2A PIK3C2A SYNJ1 SYNJ1 INPP5E INPP5E PLCB4 PLCB4 PLCB1 PLCB1 DGKH DGKH ITPR2 ITPR2 PI4KA PI4KA IMPA1 IMPA1 IMPAD1 IMPAD1 ITPR2-2 ITPR2-2 DGKB DGKB MTMR6 MTMR6 IP6K1 IP6K1 PPIP5K2 PPIP5K2 ITPKA ITPKA PLCB2 PLCB2 PIK3C3 PIK3C3 PIK3R1-2 PIK3R1-2 IP6K2 IP6K2 PRKCA PRKCA DGKE DGKE CALML6 CALML6 PIK3CD PIK3CD PI4K2B-1 PI4K2B-1 MTMR3 MTMR3 MTM1-2 MTM1-2 CDIPT CDIPT MTMR1 MTMR1 PIK3R1 PIK3R1 PIKFYVE PIKFYVE PIP5K1C PIP5K1C DGKQ DGKQ IMPA2 IMPA2 DGKA DGKA PIK3C2G-2 PIK3C2G-2 DGKI DGKI PLCZ1 PLCZ1 INPP1 INPP1 PLCG2 PLCG2 MTMR8 MTMR8 Y1Q_0015641 Y1Q_0015641 Y1Q_0023495 Y1Q_0023495 MTMR4 MTMR4 PROC PROC INPP5F INPP5F INPP5D-2 INPP5D-2 PRKCB PRKCB PLCB3 PLCB3 INPP4A-2 INPP4A-2 IP6K3 IP6K3 PLCE1 PLCE1 IPMK IPMK PTEN PTEN PLCG1 PLCG1 INPP5A INPP5A CALM3 CALM3 MTM1 MTM1 ITPKB ITPKB ITPR3 ITPR3 MTMR14 MTMR14 PIP4K2B PIP4K2B PRKCG PRKCG CDS2-2 CDS2-2 DGKK DGKK OCRL-2 OCRL-2 Y1Q_0014732 Y1Q_0014732 ITPK1 ITPK1 PI4K2B-2 PI4K2B-2 MTMR7 MTMR7 IPPK IPPK PLCD3 PLCD3 PIP4K2A PIP4K2A PLCD1 PLCD1 PIP4K2C PIP4K2C TMEM55A-1 TMEM55A-1 Y1Q_0023944 Y1Q_0023944 INPP5D INPP5D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
DGKA-2Diacylglycerol kinase. (742 aa)
SYNJ2Uncharacterized protein. (1514 aa)
TMEM55BPhosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (208 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (443 aa)
PI4KBLPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (1164 aa)
PIK3CB-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
INPP4AType I inositol 3,4-bisphosphate 4-phosphatase. (1029 aa)
PIP5K1BPIPK domain-containing protein. (618 aa)
CALML4Calmodulin-like protein 4. (153 aa)
PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform B; Belongs to the PI3/PI4-kinase family. (1673 aa)
DGKZDiacylglycerol kinase. (1022 aa)
PIK3C2AUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1691 aa)
SYNJ1PAX3-and PAX7-binding protein 1. (2276 aa)
INPP5EInositol polyphosphate 5-phosphatase. (450 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1190 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1146 aa)
DGKHDiacylglycerol kinase. (1216 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (1680 aa)
PI4KAPhosphatidylinositol 4-kinase alpha isoform A; Belongs to the PI3/PI4-kinase family. (2120 aa)
IMPA1Inositol-1-monophosphatase. (223 aa)
IMPAD1Inositol monophosphatase 3. (242 aa)
ITPR2-2Uncharacterized protein. (2702 aa)
DGKBDiacylglycerol kinase. (857 aa)
MTMR6Myotubularin-related protein 6. (618 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1325 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
PIK3R1-2Uncharacterized protein. (750 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (424 aa)
PRKCANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
DGKEDiacylglycerol kinase. (570 aa)
CALML6Calmodulin-like protein 6. (159 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
PI4K2B-1Phosphatidylinositol 4-kinase type 2-beta. (340 aa)
MTMR3Uncharacterized protein. (1166 aa)
MTM1-2Uncharacterized protein. (603 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (148 aa)
MTMR1Uncharacterized protein. (655 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
PIKFYVE1-phosphatidylinositol 3-phosphate 5-kinase isoform A. (2159 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma. (637 aa)
DGKQDiacylglycerol kinase. (973 aa)
IMPA2Inositol-1-monophosphatase. (284 aa)
DGKADiacylglycerol kinase. (903 aa)
PIK3C2G-2Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (495 aa)
DGKIDiacylglycerol kinase. (675 aa)
PLCZ1Phosphoinositide phospholipase C. (652 aa)
INPP1Inositol polyphosphate 1-phosphatase. (421 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1237 aa)
MTMR8Myotubularin phosphatase domain-containing protein. (632 aa)
Y1Q_0015641SH2 domain-containing protein. (1113 aa)
Y1Q_0023495Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
MTMR4Myotubularin-related protein 4 isoform A. (1123 aa)
PROCDiacylglycerol kinase; Belongs to the eukaryotic diacylglycerol kinase family. (1617 aa)
INPP5FPhosphatidylinositide phosphatase SAC2. (1108 aa)
INPP5D-2SH2 domain-containing protein. (1209 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
PLCB3Phosphoinositide phospholipase C. (582 aa)
INPP4A-2C2 domain-containing protein. (967 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (417 aa)
PLCE1Phosphoinositide phospholipase C. (1921 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (74 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1282 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase. (441 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (78 aa)
MTM1Myotubularin isoform B. (650 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (450 aa)
ITPR3Uncharacterized protein. (2667 aa)
MTMR14Myotubularin-related protein 14. (354 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (411 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (633 aa)
CDS2-2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (444 aa)
DGKKDiacylglycerol kinase. (1156 aa)
OCRL-2Rho-GAP domain-containing protein. (931 aa)
Y1Q_0014732Phosphoinositide phospholipase C. (1335 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (349 aa)
PI4K2B-2Phosphatidylinositol 4-kinase type 2-beta. (458 aa)
MTMR7Uncharacterized protein. (660 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (490 aa)
PLCD3Phosphoinositide phospholipase C. (755 aa)
PIP4K2APIPK domain-containing protein. (405 aa)
PLCD1Phosphoinositide phospholipase C. (783 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (458 aa)
TMEM55A-1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
Y1Q_0023944Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (323 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform A. (1485 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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