STRINGSTRING
EIF4B EIF4B WNT10A WNT10A WNT3 WNT3 WNT9A WNT9A SOS1-2 SOS1-2 AKT3 AKT3 RPS6KA2 RPS6KA2 SGK1 SGK1 PRKAA1 PRKAA1 ATP6V1F ATP6V1F PIK3CB-2 PIK3CB-2 CAB39 CAB39 PIK3CB PIK3CB FNIP2 FNIP2 WNT8A WNT8A MAP2K1-2 MAP2K1-2 IGF1R IGF1R ATP6V1D ATP6V1D INS INS LAMTOR4 LAMTOR4 ATP6V1B2 ATP6V1B2 TTI1 TTI1 Y1Q_0002897 Y1Q_0002897 GSK3B-2 GSK3B-2 TNFRSF1A TNFRSF1A NPRL2 NPRL2 ATP6V1G1 ATP6V1G1 TSC1 TSC1 AKT3-2 AKT3-2 CAB39L CAB39L SEC13 SEC13 WNT8B WNT8B ATP6V1H ATP6V1H Y1Q_0013899 Y1Q_0013899 AKT2 AKT2 FZD1 FZD1 MIOS MIOS ATP6V1A ATP6V1A WDR59 WDR59 RHOA RHOA WNT2B WNT2B RRAGD-2 RRAGD-2 RPS6KB1 RPS6KB1 ATP6V1A-2 ATP6V1A-2 PRKAA1-2 PRKAA1-2 SKP2 SKP2 SLC38A9 SLC38A9 PIK3R1-2 PIK3R1-2 ATP6V1C1 ATP6V1C1 DEPTOR-1 DEPTOR-1 WNT5B WNT5B WNT7A WNT7A MAPKAP1 MAPKAP1 WNT4 WNT4 RPS6KA3 RPS6KA3 WNT1 WNT1 TBC1D7 TBC1D7 FLCN FLCN TSC2 TSC2 PRKCA PRKCA GRB2 GRB2 SOS1-1 SOS1-1 MTOR MTOR PIK3CD PIK3CD DVL1 DVL1 DEPDC5 DEPDC5 GATSL3 GATSL3 GATSL2 GATSL2 RPS6KB1-2 RPS6KB1-2 PRR5 PRR5 TELO2 TELO2 LPIN1 LPIN1 ATP6V1C2 ATP6V1C2 LAMTOR5 LAMTOR5 FZD9 FZD9 PIK3R1 PIK3R1 WNT9B WNT9B FZD8L FZD8L FZD7 FZD7 STRADB STRADB WNT3-2 WNT3-2 ULK2 ULK2 IRS1 IRS1 ATP6V1B2-2 ATP6V1B2-2 EIF4EBP1 EIF4EBP1 SLC7A5 SLC7A5 IKBKB-2 IKBKB-2 ATP6V1G3 ATP6V1G3 WNT6 WNT6 SEH1L SEH1L RRAGD RRAGD SESN2L SESN2L IGF1 IGF1 BRAF-2 BRAF-2 WNT5B-2 WNT5B-2 ATP6V1E1 ATP6V1E1 RPS6KA1 RPS6KA1 KRAS-1 KRAS-1 AKT1S1 AKT1S1 FZD4 FZD4 LAMTOR3 LAMTOR3 EIF4E EIF4E WNT11B WNT11B RPS6KA6-2 RPS6KA6-2 TNF TNF MAPK1 MAPK1 ULK1A ULK1A FZD10 FZD10 SLC3A2 SLC3A2 Y1Q_0020451 Y1Q_0020451 PRKCB PRKCB MLST8 MLST8 LRP5 LRP5 MAP2K1 MAP2K1 LAMTOR2 LAMTOR2 EIF4E1B EIF4E1B INSR-2 INSR-2 Y1Q_0002620 Y1Q_0002620 LPIN3 LPIN3 DDIT4 DDIT4 PTEN PTEN STK11 STK11 GRB10-2 GRB10-2 FZD3 FZD3 RPS6 RPS6 RPTOR RPTOR PRKCG PRKCG NPRL3 NPRL3 WNT7B WNT7B LRP6-2 LRP6-2 RRAGB RRAGB FZD2 FZD2 STRADA STRADA FZD8 FZD8 RHEB RHEB DVL3 DVL3 EIF4E2-1 EIF4E2-1 WNT2 WNT2 WNT16 WNT16 IKBKB IKBKB NRAS NRAS BRAF BRAF LAMTOR1 LAMTOR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4BEukaryotic translation initiation factor 4B. (630 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (413 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (295 aa)
SOS1-2Son of sevenless-like protein. (1379 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
SGK1Serine/threonine-protein kinase Sgk1 isoform A; Belongs to the protein kinase superfamily. (400 aa)
PRKAA1Non-specific serine/threonine protein kinase. (527 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
PIK3CB-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
CAB39Calcium-binding protein 39. (341 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNIP2Folliculin-interacting protein 2 isoform A. (1174 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
MAP2K1-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
ATP6V1DV-type proton ATPase subunit D. (228 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (147 aa)
LAMTOR4Ragulator complex protein LAMTOR4. (99 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (451 aa)
TTI1TELO2-interacting 1-like protein. (1111 aa)
Y1Q_0002897Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
GSK3B-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (412 aa)
NPRL2Nitrogen permease regulator 2-like protein. (405 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
TSC1Hamartin isoform B. (1115 aa)
AKT3-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CAB39LUncharacterized protein. (313 aa)
SEC13SEC13-like protein; Belongs to the WD repeat SEC13 family. (320 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ATP6V1HV-type proton ATPase subunit H. (514 aa)
Y1Q_0013899Uncharacterized protein. (103 aa)
AKT2Non-specific serine/threonine protein kinase. (270 aa)
FZD1G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (335 aa)
MIOSWD repeat-containing protein mio. (860 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (617 aa)
WDR59WD repeat-containing protein 59. (973 aa)
RHOATransforming protein RhoA. (255 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
RRAGD-2Uncharacterized protein. (410 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (475 aa)
ATP6V1A-2Uncharacterized protein. (644 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
SKP2S-phase kinase-associated protein 2. (419 aa)
SLC38A9Sodium-coupled neutral amino acid transporter 9. (561 aa)
PIK3R1-2Uncharacterized protein. (750 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (415 aa)
DEPTOR-1DEP domain-containing mTOR-interacting protein isoform B. (397 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (395 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (540 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (914 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
TBC1D7TBC1 domain family member 7. (270 aa)
FLCNFolliculin. (629 aa)
TSC2Tuberin isoform D. (1829 aa)
PRKCANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SOS1-1Son of sevenless-like protein 1 isoform A. (1305 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
DVL1Uncharacterized protein. (693 aa)
DEPDC5DEP domain-containing protein 5 isoform B. (1604 aa)
GATSL3GATS-like protein 3. (330 aa)
GATSL2GATS-like protein 2. (329 aa)
RPS6KB1-2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
PRR5Proline-rich protein 5 isoform B. (468 aa)
TELO2Telomere length regulation TEL2-like protein isoform B. (774 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform B. (975 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (424 aa)
LAMTOR5Ragulator complex protein LAMTOR5. (91 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
FZD8LFrizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
FZD7G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (331 aa)
STRADBSTE20-related kinase adapter protein beta. (417 aa)
WNT3-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ULK2Serine/threonine-protein kinase ULK2. (1048 aa)
IRS1Insulin receptor substrate 1 isoform B. (809 aa)
ATP6V1B2-2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (509 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (112 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (511 aa)
IKBKB-2Uncharacterized protein. (757 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (125 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (360 aa)
RRAGDRas-related GTP-binding protein D. (333 aa)
SESN2LSestrin 2. (509 aa)
IGF1Insulin-like growth factor I. (153 aa)
BRAF-2Uncharacterized protein. (791 aa)
WNT5B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
RPS6KA1Ribosomal protein S6 kinase. (758 aa)
KRAS-1GTPase KRas. (215 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
FZD4Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (465 aa)
LAMTOR3Ragulator complex protein LAMTOR3. (124 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
WNT11BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (811 aa)
RPS6KA6-2Ribosomal protein S6 kinase. (747 aa)
TNFTumor necrosis factor. (231 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
ULK1AUnc-51 like autophagy activating kinase 1a isoform A. (1048 aa)
FZD10Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
SLC3A24F2 cell-surface antigen heavy chain. (291 aa)
Y1Q_0020451Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (687 aa)
MLST8Target of rapamycin complex subunit LST8. (403 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (377 aa)
LAMTOR2Ragulator complex protein LAMTOR2. (173 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
INSR-2Tyrosine-protein kinase receptor. (1352 aa)
Y1Q_0002620Uncharacterized protein. (466 aa)
LPIN3LNS2 domain-containing protein. (944 aa)
DDIT4DNA damage-inducible transcript 4 protein. (172 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (418 aa)
GRB10-2Uncharacterized protein. (665 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (632 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RPTORRegulatory-associated protein of mTOR isoform A. (1352 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (633 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform C. (585 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LRP6-2Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
RRAGBRas-related GTP-binding protein A. (327 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
STRADASTE20-related kinase adapter protein alpha. (373 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (242 aa)
RHEBGTP-binding protein Rheb. (184 aa)
DVL3Segment polarity dishevelled-like protein DVL-3 isoform B. (732 aa)
EIF4E2-1Eukaryotic translation initiation factor 4E type 2 isoform B; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (255 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (730 aa)
NRASGTPase NRas. (189 aa)
BRAFSerine/threonine-protein kinase B-raf. (651 aa)
LAMTOR1Ragulator complex protein LAMTOR1. (161 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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