STRINGSTRING
STAT6 STAT6 Y1Q_0020082 Y1Q_0020082 Y1Q_0020090 Y1Q_0020090 Y1Q_0020102 Y1Q_0020102 HIST1H2A3 HIST1H2A3 PYGB-2 PYGB-2 TNFAIP3 TNFAIP3 FAF1 FAF1 USP21 USP21 TNFSF10 TNFSF10 VDAC1 VDAC1 H2AFY H2AFY MAPK9 MAPK9 CAMK2G CAMK2G SQSTM1 SQSTM1 JAK2 JAK2 CHMP4A CHMP4A TNFRSFA TNFRSFA TNFRSF1A TNFRSF1A CHMP2B CHMP2B IFNAR2-1 IFNAR2-1 IFNGR2 IFNGR2 IFNAR1 IFNAR1 TRAF2 TRAF2 Y1Q_0005592 Y1Q_0005592 TLR4 TLR4 EIF2AK2 EIF2AK2 CAPN11 CAPN11 PLA2G4C PLA2G4C GLUL GLUL PLA2G4A PLA2G4A Y1Q_0023709 Y1Q_0023709 MAPK8 MAPK8 TRADD TRADD PPIA-1 PPIA-1 IL1B IL1B CYLD CYLD Y1Q_0021261 Y1Q_0021261 VDAC2 VDAC2 GLUD1 GLUD1 CAPN1 CAPN1 Y1Q_0016002 Y1Q_0016002 PLA2G4F PLA2G4F PLA2G4B PLA2G4B PLA2G4E PLA2G4E Y1Q_0015998 Y1Q_0015998 Y1Q_0015999 Y1Q_0015999 TYK2 TYK2 PYGL PYGL SPATA2L SPATA2L CHMP1A CHMP1A SHRPRBCK1R SHRPRBCK1R Y1Q_0007828 Y1Q_0007828 CFLAR CFLAR CASP18 CASP18 STAT4-2 STAT4-2 CASP8-1 CASP8-1 STAT1 STAT1 PYCARDL PYCARDL VDAC3 VDAC3 RIPK1 RIPK1 VPS4B-2 VPS4B-2 PYGB PYGB Y1Q_0018182 Y1Q_0018182 DNM1L DNM1L BID BID JAK1 JAK1 Y1Q_0008411 Y1Q_0008411 Y1Q_0008409 Y1Q_0008409 BAX BAX FTL FTL IRF9 IRF9 H2AFZ H2AFZ XIAP XIAP SLC25A4 SLC25A4 CHMP1B CHMP1B AIFM1 AIFM1 VPS4B VPS4B H2AFV H2AFV TNF TNF SUCO-1 SUCO-1 CASP1 CASP1 Y1Q_0006753 Y1Q_0006753 NOX3 NOX3 Y1Q_0020480 Y1Q_0020480 Y1Q_0006235 Y1Q_0006235 SLC25A6 SLC25A6 FTH1 FTH1 NLRP3 NLRP3 ZBP1 ZBP1 FAS FAS H2AFY2 H2AFY2 H2AFX H2AFX HSP90AA1 HSP90AA1 PARP1 PARP1 CAPN3 CAPN3 TRAF5 TRAF5 Y1Q_0021874 Y1Q_0021874 CHMP6 CHMP6 CHMP2A CHMP2A CHMP7-1 CHMP7-1 STAT3 STAT3 TNFRSF10B TNFRSF10B CHMP4B CHMP4B SMPD1 SMPD1 JAK3 JAK3 BIRC2 BIRC2 CYLDL CYLDL HSP90AA1-2 HSP90AA1-2 TLR3 TLR3 SLC25A4-2 SLC25A4-2 PPID PPID STAT4 STAT4 STAT5B STAT5B SLC25A31 SLC25A31 IFNG IFNG RIPK3 RIPK3 Y1Q_0010619 Y1Q_0010619 CHMP4C CHMP4C CHMP5 CHMP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT6Signal transducer and activator of transcription 6. (600 aa)
Y1Q_0020082Histone H2A; Belongs to the histone H2A family. (127 aa)
Y1Q_0020090Histone H2A; Belongs to the histone H2A family. (129 aa)
Y1Q_0020102Histone H2A; Belongs to the histone H2A family. (130 aa)
HIST1H2A3Histone H2A; Belongs to the histone H2A family. (129 aa)
PYGB-2Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (853 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (853 aa)
FAF1FAS-associated factor 1. (745 aa)
USP21Ubiquitin carboxyl-terminal hydrolase. (458 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (295 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (581 aa)
H2AFYCore histone macro-H2A.1 isoform C; Belongs to the histone H2A family. (435 aa)
MAPK9Mitogen-activated protein kinase. (430 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform B; Belongs to the protein kinase superfamily. (489 aa)
SQSTM1Sequestosome-1. (457 aa)
JAK2Tyrosine-protein kinase. (1124 aa)
CHMP4ACharged multivesicular body protein 4a. (218 aa)
TNFRSFATumor necrosis factor receptor superfamily member 6-like. (427 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (412 aa)
CHMP2BCharged multivesicular body protein 2b. (214 aa)
IFNAR2-1Interferon alpha/beta receptor 2 isoform B. (313 aa)
IFNGR2Interferon gamma receptor 2. (313 aa)
IFNAR1Interferon alpha/beta receptor 1. (569 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (601 aa)
Y1Q_0005592Glutamine synthetase. (374 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (532 aa)
CAPN11Uncharacterized protein; Belongs to the peptidase C2 family. (705 aa)
PLA2G4CCytosolic phospholipase A2 gamma. (499 aa)
GLULGlutamine synthetase. (373 aa)
PLA2G4APhospholipase A2. (749 aa)
Y1Q_0023709Histone H2A; Belongs to the histone H2A family. (126 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (336 aa)
PPIA-1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (156 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (448 aa)
CYLDUncharacterized protein. (949 aa)
Y1Q_0021261Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (180 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (303 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (490 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (964 aa)
Y1Q_0016002Phospholipase A2. (1782 aa)
PLA2G4FPhospholipase A2. (824 aa)
PLA2G4BPhospholipase A2. (815 aa)
PLA2G4EPhospholipase A2. (839 aa)
Y1Q_0015998Phospholipase A2. (824 aa)
Y1Q_0015999PLA2c domain-containing protein. (717 aa)
TYK2Tyrosine-protein kinase. (1184 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (864 aa)
SPATA2LSpermatogenesis-associated protein 2-like protein. (438 aa)
CHMP1ACharged multivesicular body protein 1a. (196 aa)
SHRPRBCK1RRanBP-type and C3HC4-type zinc finger-containing protein 1 isoform A. (480 aa)
Y1Q_0007828Uncharacterized protein. (597 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (530 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (424 aa)
STAT4-2Signal transducer and activator of transcription. (742 aa)
CASP8-1Caspase-8 isoform B; Belongs to the peptidase C14A family. (462 aa)
STAT1Signal transducer and activator of transcription. (753 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (296 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (699 aa)
VPS4B-2Uncharacterized protein; Belongs to the AAA ATPase family. (463 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
Y1Q_0018182Histone H2A; Belongs to the histone H2A family. (150 aa)
DNM1LDynamin-1-like protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (696 aa)
BIDBH3-interacting domain death agonist. (137 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
Y1Q_0008411Apoptosis regulator BAX-like. (187 aa)
Y1Q_0008409Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
BAXApoptosis regulator BAX. (209 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (176 aa)
IRF9Interferon regulatory factor 9 isoform A. (401 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (558 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CHMP1BCharged multivesicular body protein 1b. (199 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial. (603 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (463 aa)
H2AFVHistone H2A; Belongs to the histone H2A family. (128 aa)
TNFTumor necrosis factor. (231 aa)
SUCO-1SUN domain-containing ossification factor isoform A; Belongs to the tumor necrosis factor family. (1247 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (395 aa)
Y1Q_0006753Histone H2A; Belongs to the histone H2A family. (129 aa)
NOX3XK-related protein. (789 aa)
Y1Q_0020480Histone H2A; Belongs to the histone H2A family. (191 aa)
Y1Q_0006235Histone H2A; Belongs to the histone H2A family. (210 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (212 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 12. (901 aa)
ZBP1Z-DNA-binding protein 1. (436 aa)
FASTumor necrosis factor receptor superfamily member 6. (341 aa)
H2AFY2Core histone macro-H2A.2; Belongs to the histone H2A family. (339 aa)
H2AFXHistone H2A; Belongs to the histone H2A family. (140 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (812 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
CAPN3Calpain-3; Belongs to the peptidase C2 family. (700 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (588 aa)
Y1Q_0021874ELFV_dehydrog_N domain-containing protein. (231 aa)
CHMP6Charged multivesicular body protein 6. (187 aa)
CHMP2ACharged multivesicular body protein 2a. (220 aa)
CHMP7-1Charged multivesicular body protein 7 isoform A. (398 aa)
STAT3Signal transducer and activator of transcription. (727 aa)
TNFRSF10BTumor necrosis factor receptor superfamily member 10B. (394 aa)
CHMP4BCharged multivesicular body protein 4b. (211 aa)
SMPD1Sphingomyelin phosphodiesterase. (287 aa)
JAK3Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (487 aa)
BIRC2Inhibitor of apoptosis protein. (493 aa)
CYLDLUbiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
HSP90AA1-2HATPase_c domain-containing protein. (771 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (948 aa)
SLC25A4-2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
STAT4Signal transducer and activator of transcription. (849 aa)
STAT5BSignal transducer and activator of transcription 5B isoform B. (593 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (125 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3. (508 aa)
Y1Q_0010619Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (1690 aa)
CHMP4CCharged multivesicular body protein 4c. (221 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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