STRINGSTRING
trpv4 trpv4 CALM1 CALM1 TGFBR2 TGFBR2 MRAS MRAS Y1Q_0012783 Y1Q_0012783 AKT3 AKT3 Y1Q_0007720 Y1Q_0007720 PIK3CB-2 PIK3CB-2 CDK4 CDK4 PIK3CB PIK3CB VDAC1 VDAC1 RAD50 RAD50 SQSTM1 SQSTM1 GADD45G GADD45G SMAD3 SMAD3 CALML4 CALML4 MAP2K1-2 MAP2K1-2 CCNB2 CCNB2 MAPKAPK3 MAPKAPK3 ZFP36L1 ZFP36L1 CCND1 CCND1 RRAS2 RRAS2 TSC1 TSC1 RBL1 RBL1 PPP3R1 PPP3R1 AKT3-2 AKT3-2 CAPN11 CAPN11 ITM2B ITM2B CDK2 CDK2 TRAF3IP2 TRAF3IP2 GADD45B GADD45B ITPR2 ITPR2 TGFB3 TGFB3 Y1Q_0017073 Y1Q_0017073 RBBP4-2 RBBP4-2 Y1Q_0013899 Y1Q_0013899 CCNA1-1 CCNA1-1 ITPR2-2 ITPR2-2 AKT2 AKT2 CDK6 CDK6 TGFBR2-2 TGFBR2-2 RBL2 RBL2 PPP3CB PPP3CB VDAC2 VDAC2 CAPN1 CAPN1 RAD9A RAD9A Y1Q_0023912 Y1Q_0023912 PPP1CA-2 PPP1CA-2 CDK1 CDK1 GATA4 GATA4 TP53 TP53 SMAD2-2 SMAD2-2 RAD1 RAD1 PIK3R1-2 PIK3R1-2 CCNE2-1 CCNE2-1 CACNA1D CACNA1D Y1Q_0009496 Y1Q_0009496 RELA RELA RRAS RRAS MAP2K3 MAP2K3 TSC2 TSC2 MAP2K6 MAP2K6 CALML6 CALML6 MTOR MTOR PIK3CD PIK3CD CXCL8A CXCL8A CXCL8-2 CXCL8-2 IL8L1 IL8L1 CCNE1 CCNE1 CDKN1A CDKN1A MAPK14 MAPK14 PIK3R1 PIK3R1 CDC25A CDC25A Y1Q_0016787 Y1Q_0016787 CCND3 CCND3 PPP3CC-2 PPP3CC-2 EIF4EBP1 EIF4EBP1 VDAC3 VDAC3 Y1Q_0016246 Y1Q_0016246 LIN37 LIN37 NFATC1 NFATC1 E2F2-1 E2F2-1 ETS1 ETS1 CHEK1 CHEK1 DCLRE1B DCLRE1B HIPK2 HIPK2 KRAS-1 KRAS-1 GADD45A GADD45A LIN52 LIN52 CHEK2 CHEK2 Y1Q_0002224 Y1Q_0002224 PPP3CC PPP3CC NFKB1 NFKB1 SLC25A4 SLC25A4 Y1Q_0023495 Y1Q_0023495 Y1Q_0017882 Y1Q_0017882 MAPK1 MAPK1 PPP1CC PPP1CC Y1Q_0020451 Y1Q_0020451 SLC25A6 SLC25A6 MAP2K1 MAP2K1 BF1 BF1 NFATC1L NFATC1L PTEN PTEN MCU MCU TGFB1 TGFB1 SERPINE1 SERPINE1 MYBL2 MYBL2 SIRT1 SIRT1 CALM3 CALM3 LIN54 LIN54 MRE11A MRE11A CXCL8-3 CXCL8-3 IGFBP3 IGFBP3 LIN9 LIN9 TGFB2 TGFB2 CAPN3 CAPN3 ZFP36L2 ZFP36L2 PPP1CA PPP1CA Y1Q_0016622 Y1Q_0016622 Y1Q_0019426 Y1Q_0019426 Y1Q_0016625 Y1Q_0016625 ITPR3 ITPR3 Y1Q_0007688 Y1Q_0007688 Y1Q_0007689 Y1Q_0007689 Y1Q_0019425 Y1Q_0019425 E2F1 E2F1 CCND2 CCND2 FOXM1 FOXM1 CDKN1D CDKN1D ATM ATM CCNB3 CCNB3 SLC25A4-2 SLC25A4-2 PPID PPID HUS1 HUS1 RHEB RHEB SLC25A31 SLC25A31 MAPK12 MAPK12 CCNA2 CCNA2 MDM2 MDM2 MAPK11 MAPK11 E2F5 E2F5 CCNB1 CCNB1 NRAS NRAS TGFBR1 TGFBR1 BRAF BRAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpv4Transient receptor potential cation channel subfamily V member 4 isoform A; Belongs to the transient receptor (TC 1.A.4) family. (857 aa)
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
MRASRas-related protein M-Ras. (237 aa)
Y1Q_0012783Ig-like domain-containing protein; Belongs to the MHC class I family. (351 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Y1Q_0007720C-type lectin lectoxin-Thr1-like. (473 aa)
PIK3CB-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (581 aa)
RAD50DNA repair protein RAD50. (1448 aa)
SQSTM1Sequestosome-1. (457 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
CALML4Calmodulin-like protein 4. (153 aa)
MAP2K1-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (354 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1. (335 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
RRAS2Ras-related protein R-Ras2. (213 aa)
TSC1Hamartin isoform B. (1115 aa)
RBL1Retinoblastoma-like protein 1 isoform A. (1076 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
AKT3-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CAPN11Uncharacterized protein; Belongs to the peptidase C2 family. (705 aa)
ITM2BIntegral membrane protein 2B isoform B. (1151 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
TRAF3IP2Adapter protein CIKS. (557 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (158 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (1680 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
Y1Q_0017073Ig-like domain-containing protein; Belongs to the MHC class I family. (391 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
Y1Q_0013899Uncharacterized protein. (103 aa)
CCNA1-1Cyclin-A1 isoform C; Belongs to the cyclin family. (445 aa)
ITPR2-2Uncharacterized protein. (2702 aa)
AKT2Non-specific serine/threonine protein kinase. (270 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TGFBR2-2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
RBL2Uncharacterized protein. (1056 aa)
PPP3CBSerine/threonine-protein phosphatase. (509 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (303 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (964 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (392 aa)
Y1Q_0023912RT1 class I histocompatibility antigen, AA alpha chain-like; Belongs to the MHC class I family. (242 aa)
PPP1CA-2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
GATA4Transcription factor GATA-4. (410 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
SMAD2-2Mothers against decapentaplegic homolog. (512 aa)
RAD1Cell cycle checkpoint protein RAD1. (253 aa)
PIK3R1-2Uncharacterized protein. (750 aa)
CCNE2-1G1/S-specific cyclin-E2 isoform B; Belongs to the cyclin family. (410 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
Y1Q_0009496Major histocompatibility complex class I-related protein-like; Belongs to the MHC class I family. (315 aa)
RELATranscription factor p65. (350 aa)
RRASRas-related protein R-Ras. (202 aa)
MAP2K3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
TSC2Tuberin isoform D. (1829 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (348 aa)
CALML6Calmodulin-like protein 6. (159 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
CXCL8AInterleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
CXCL8-2Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
IL8L1Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (408 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (232 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
CDC25AM-phase inducer phosphatase 1. (510 aa)
Y1Q_0016787Ig-like domain-containing protein; Belongs to the MHC class I family. (366 aa)
CCND3G1/S-specific cyclin-D3; Belongs to the cyclin family. (293 aa)
PPP3CC-2Serine/threonine-protein phosphatase. (1065 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (112 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (296 aa)
Y1Q_0016246Major histocompatibility complex class I-related protein-like; Belongs to the MHC class I family. (414 aa)
LIN37Lin-37-like protein. (234 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform B. (929 aa)
E2F2-1Transcription factor E2F2 isoform A. (382 aa)
ETS1Protein C-ets-1 isoform B. (540 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
DCLRE1B5' exonuclease Apollo isoform B. (1619 aa)
HIPK2Protein kinase domain-containing protein. (1175 aa)
KRAS-1GTPase KRas. (215 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (70 aa)
LIN52Lin-52-like protein. (112 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform B. (433 aa)
Y1Q_0002224Major histocompatibility complex class I-related protein-like; Belongs to the MHC class I family. (364 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform B. (1031 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
Y1Q_0023495Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
Y1Q_0017882Ig-like domain-containing protein; Belongs to the MHC class I family. (344 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
Y1Q_0020451Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (377 aa)
BF1MHC BF1 class I; Belongs to the MHC class I family. (350 aa)
NFATC1LNuclear factor of activated T-cells, cytoplasmic 1. (929 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MCUCalcium uniporter protein, mitochondrial. (309 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
SERPINE1Serpin E3-like; Belongs to the serpin family. (527 aa)
MYBL2Myb-related protein B. (689 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (78 aa)
LIN54Lin-54-like protein isoform B. (828 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (720 aa)
CXCL8-3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (282 aa)
LIN9Lin-9-like protein isoform B. (636 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
CAPN3Calpain-3; Belongs to the peptidase C2 family. (700 aa)
ZFP36L2Tis11B_N domain-containing protein. (90 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
Y1Q_0016622Major histocompatibility complex class I-related protein-like. (344 aa)
Y1Q_0019426Major histocompatibility complex class I-related protein-like; Belongs to the MHC class I family. (401 aa)
Y1Q_0016625Class I histocompatibility antigen, F10 alpha chain-like; Belongs to the MHC class I family. (344 aa)
ITPR3Uncharacterized protein. (2667 aa)
Y1Q_0007688Major histocompatibility complex class I-related protein-like; Belongs to the MHC class I family. (352 aa)
Y1Q_0007689Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
Y1Q_0019425Major histocompatibility complex class I-related protein-like; Belongs to the MHC class I family. (357 aa)
E2F1Transcription factor E2F1. (426 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (291 aa)
FOXM1Forkhead box protein M1. (331 aa)
CDKN1DCyclin-dependent kinase inhibitor 1D. (153 aa)
ATMNon-specific serine/threonine protein kinase. (3063 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (435 aa)
SLC25A4-2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
RHEBGTP-binding protein Rheb. (184 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
MAPK12Mitogen-activated protein kinase. (309 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (382 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
E2F5Transcription factor E2F5. (386 aa)
CCNB1G2/mitotic-specific cyclin-B1 isoform B; Belongs to the cyclin family. (411 aa)
NRASGTPase NRas. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
BRAFSerine/threonine-protein kinase B-raf. (651 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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