STRINGSTRING
CALM1 CALM1 MYL3 MYL3 RAPGEF5 RAPGEF5 ATF2 ATF2 CACNB1 CACNB1 ADCY3 ADCY3 SLC8A1 SLC8A1 PPP2R5E PPP2R5E AKT3 AKT3 AGT AGT RYR2 RYR2 RAPGEF3 RAPGEF3 ADRB2 ADRB2 PPP2R2B PPP2R2B CAMK2G CAMK2G GNA11 GNA11 CALML4 CALML4 TPM1-1 TPM1-1 SLC8A3-2 SLC8A3-2 Y1Q_0000544 Y1Q_0000544 KCNQ1 KCNQ1 PPP2R1A PPP2R1A CACNB3 CACNB3 PPP2R5D PPP2R5D ATP1B1 ATP1B1 ATP1A1-2 ATP1A1-2 CACNA2D2 CACNA2D2 PLCB4 PLCB4 PLCB1 PLCB1 AKT3-2 AKT3-2 Y1Q_0013899 Y1Q_0013899 AKT2 AKT2 CREB5 CREB5 ADCY7 ADCY7 PPP2R5B PPP2R5B PPP1CA-2 PPP1CA-2 ADCY6 ADCY6 PLCB2 PLCB2 ACTC1-2 ACTC1-2 ADRA1D ADRA1D CACNA1D CACNA1D CACNA2D4 CACNA2D4 CACNG4 CACNG4 PRKCA PRKCA CACNG1 CACNG1 CACNG5 CACNG5 CALML6 CALML6 PPP2CB PPP2CB ATP2A3 ATP2A3 AGTR2 AGTR2 MAPK14 MAPK14 CACNA1E CACNA1E CREB1 CREB1 ATP1B3 ATP1B3 ATP2B4-2 ATP2B4-2 ADCY2-2 ADCY2-2 ATP2B4 ATP2B4 FXYD2-1 FXYD2-1 TNNC1 TNNC1 PPP2R3B PPP2R3B ATF4-2 ATF4-2 CACNG2 CACNG2 CREB3L2 CREB3L2 CACNA2D4-2 CACNA2D4-2 CACNA1C CACNA1C PRKACB PRKACB SLC9A1 SLC9A1 Y1Q_0006499 Y1Q_0006499 PPP2R3C PPP2R3C SCN1B SCN1B ATP1B4 ATP1B4 PIK3CG PIK3CG CACNA2D1 CACNA2D1 Y1Q_0023495 Y1Q_0023495 MYH6 MYH6 MAPK1 MAPK1 PPP1CC PPP1CC MYL2 MYL2 ATP2A2 ATP2A2 Y1Q_0020451 Y1Q_0020451 ADRB1 ADRB1 PIK3R5 PIK3R5 PIK3R6 PIK3R6 CACNG3 CACNG3 TPM2-1 TPM2-1 CREB3L3-1 CREB3L3-1 PLCB3 PLCB3 PPP2R3B-2 PPP2R3B-2 TPM4 TPM4 Y1Q_0020807 Y1Q_0020807 CALM3 CALM3 ADCY3-2 ADCY3-2 ADCY1 ADCY1 ATP1A1 ATP1A1 PPP2R5C PPP2R5C SLC8A3 SLC8A3 PPP1CA PPP1CA CACNG6 CACNG6 CACNG8 CACNG8 ADRA1A ADRA1A PPP2R2A PPP2R2A CACNG7 CACNG7 CACNB1-2 CACNB1-2 GNAI3 GNAI3 KCNQ1L KCNQ1L PPP2R5C-2 PPP2R5C-2 RPS6KA6 RPS6KA6 PPP2R2C PPP2R2C MYL4 MYL4 Y1Q_0006967 Y1Q_0006967 CACNB2 CACNB2 Y1Q_0014532 Y1Q_0014532 MAPK12 MAPK12 MAPK11 MAPK11 ADCY2 ADCY2 CACNA1F CACNA1F CREB3L4 CREB3L4 TPM3-1 TPM3-1 ATP2A1 ATP2A1 ATF6B ATF6B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALM1Calmodulin; Belongs to the calmodulin family. (149 aa)
MYL3Myosin light chain 3. (214 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (873 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (458 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform A. (486 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1017 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (668 aa)
PPP2R5ESerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (515 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AGTAngiotensinogen; Belongs to the serpin family. (474 aa)
RYR2Uncharacterized protein. (5012 aa)
RAPGEF3Uncharacterized protein. (874 aa)
ADRB2Beta-2 adrenergic receptor. (392 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform B; Belongs to the protein kinase superfamily. (489 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (333 aa)
CALML4Calmodulin-like protein 4. (153 aa)
TPM1-1Tropomyosin alpha-1 chain isoform E; Belongs to the tropomyosin family. (326 aa)
SLC8A3-2Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (936 aa)
Y1Q_0000544Uncharacterized protein. (377 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1 isoform A; Belongs to the potassium channel family. (692 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform. (643 aa)
CACNB3SH3 domain-containing protein. (479 aa)
PPP2R5DSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (596 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (305 aa)
ATP1A1-2Sodium/potassium-transporting ATPase subunit alpha. (1022 aa)
CACNA2D2VWFA domain-containing protein. (833 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1190 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1146 aa)
AKT3-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Y1Q_0013899Uncharacterized protein. (103 aa)
AKT2Non-specific serine/threonine protein kinase. (270 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (552 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1074 aa)
PPP2R5BSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (493 aa)
PPP1CA-2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ADCY6Uncharacterized protein. (1272 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1207 aa)
ACTC1-2Uncharacterized protein. (377 aa)
ADRA1DAlpha-1D adrenergic receptor. (507 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4 isoform C. (838 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
PRKCANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (294 aa)
CALML6Calmodulin-like protein 6. (159 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1043 aa)
AGTR2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (369 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CACNA1EVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1843 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ATP2B4-2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1293 aa)
ADCY2-2Guanylate cyclase domain-containing protein. (226 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (664 aa)
FXYD2-1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (86 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (1138 aa)
ATF4-2Cyclic AMP-dependent transcription factor ATF-4. (124 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
CACNA2D4-2VWFA domain-containing protein. (1071 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1954 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform C; Belongs to the protein kinase superfamily. (368 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (802 aa)
Y1Q_0006499Uncharacterized protein; Belongs to the protein kinase superfamily. (401 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (450 aa)
SCN1BSodium channel subunit beta-1. (219 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (321 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (810 aa)
CACNA2D1Calcium channel, voltage-dependent, alpha 2/delta subunit 1 preproprotein isoform B. (989 aa)
Y1Q_0023495Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
MYH6Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (165 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1035 aa)
Y1Q_0020451Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
ADRB1Beta-1 adrenergic receptor. (383 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (886 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (754 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
TPM2-1Tropomyosin beta chain isoform B; Belongs to the tropomyosin family. (339 aa)
CREB3L3-1Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform B. (499 aa)
PLCB3Phosphoinositide phospholipase C. (582 aa)
PPP2R3B-2Uncharacterized protein. (569 aa)
TPM4Tropomyosin alpha-4 chain; Belongs to the tropomyosin family. (275 aa)
Y1Q_0020807Sodium/potassium-transporting ATPase subunit alpha. (947 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (78 aa)
ADCY3-2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1026 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (479 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (599 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (255 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (358 aa)
ADRA1AAlpha-1A adrenergic receptor. (335 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNB1-2SH3 domain-containing protein. (646 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (344 aa)
KCNQ1LPotassium voltage-gated channel subfamily KQT member 1 isoform C; Belongs to the potassium channel family. (477 aa)
PPP2R5C-2Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (602 aa)
RPS6KA6Ribosomal protein S6 kinase. (820 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
MYL4Uncharacterized protein. (203 aa)
Y1Q_0006967Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1194 aa)
CACNB2SH3 domain-containing protein. (612 aa)
Y1Q_0014532Uncharacterized protein. (1758 aa)
MAPK12Mitogen-activated protein kinase. (309 aa)
MAPK11Mitogen-activated protein kinase. (361 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (959 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1276 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform A. (417 aa)
TPM3-1Tropomyosin alpha-3 chain isoform C; Belongs to the tropomyosin family. (388 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (994 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (666 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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