(59 nodes) Adherens junction network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TCF7L1	Transcription factor 7-like 1 isoform D. (567 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	MLLT4	Afadin isoform F. (1923 aa)
	WAS	Wiskott-Aldrich syndrome protein. (367 aa)
	Y1Q_0015214	Uncharacterized protein. (749 aa)
	TCF7	Transcription factor 7 isoform A. (452 aa)
	SMAD3	Mothers against decapentaplegic homolog. (426 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1363 aa)
	TJP1-2	Uncharacterized protein; Belongs to the MAGUK family. (1154 aa)
	ACTN1	Uncharacterized protein. (914 aa)
	PTPRJ	Receptor-type tyrosine-protein phosphatase eta isoform A. (1187 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
	PVRL3L	Nectin-3. (210 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform B. (391 aa)
	FARP2	FERM, RhoGEF and pleckstrin domain-containing protein 2. (1019 aa)
	IQGAP2	Ras GTPase-activating-like protein IQGAP2. (1214 aa)
	SNAI2	Zinc finger protein SNAI2. (268 aa)
	Y1Q_0013899	Uncharacterized protein. (103 aa)
	TGFBR2-2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
	PVRL4	Nectin-4. (508 aa)
	CSNK2A2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (392 aa)
	RHOA	Transforming protein RhoA. (255 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7 isoform A. (610 aa)
	CTNNA2-2	Uncharacterized protein. (603 aa)
	CDC42	Cell division control 42-like protein. (235 aa)
	NLK	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (524 aa)
	FGFR2	Fibroblast growth factor receptor. (818 aa)
	YES1	Tyrosine-protein kinase. (1013 aa)
	PTPRM-2	Uncharacterized protein. (1418 aa)
	CREBBP	CREB-binding protein isoform C. (2208 aa)
	RAC2	Uncharacterized protein. (179 aa)
	Y1Q_0014123	Uncharacterized protein. (1097 aa)
	Y1Q_0015577	Wiskott-Aldrich syndrome protein family member 3-like. (509 aa)
	PVRL1	Nectin-1. (710 aa)
	CTNNA2	Catenin alpha-2 isoform A. (939 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (410 aa)
	Y1Q_0020451	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (281 aa)
	ACTB	Uncharacterized protein. (400 aa)
	Y1Q_0009006	Alpha-ketoglutarate-dependent dioxygenase alkB-like protein 7, mitochondrial. (713 aa)
	CTNND1	Catenin delta-1 isoform B. (996 aa)
	CSNK2A1	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (435 aa)
	INSR-2	Tyrosine-protein kinase receptor. (1352 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	SRC-2	Tyrosine-protein kinase. (546 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (834 aa)
	EGFR	Uncharacterized protein. (633 aa)
	CTNNB1	Catenin beta-1 isoform B. (783 aa)
	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform A. (541 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1262 aa)
	BAIAP2L	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform B. (551 aa)
	ACTN4	Uncharacterized protein. (893 aa)
	PVRL2	Poliovirus receptor-related protein 2. (466 aa)
	PARD3	Partitioning defective 3-like protein isoform A. (1225 aa)
	MET-2	Uncharacterized protein. (1348 aa)
	PTPRR	Receptor-type tyrosine-protein phosphatase R. (2872 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
	FER	Tyrosine-protein kinase Fer. (954 aa)
	SMAD4	Mothers against decapentaplegic homolog. (559 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTN1	A0A151NTY8	A0A151MB02	Uncharacterized protein.	Uncharacterized protein.	0.938
ACTB	ACTN4	A0A151NTY8	A0A151P6Y2	Uncharacterized protein.	Uncharacterized protein.	0.938
ACTB	BAIAP2	A0A151NTY8	A0A151P440	Uncharacterized protein.	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform A.	0.931
ACTB	BAIAP2L	A0A151NTY8	A0A151P5Q5	Uncharacterized protein.	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform B.	0.914
ACTB	CTNNA2	A0A151NTY8	A0A151NQU8	Uncharacterized protein.	Catenin alpha-2 isoform A.	0.919
ACTB	CTNNA2-2	A0A151NTY8	A0A151MYH6	Uncharacterized protein.	Uncharacterized protein.	0.919
ACTB	IQGAP2	A0A151NTY8	A0A151MKP1	Uncharacterized protein.	Ras GTPase-activating-like protein IQGAP2.	0.932
ACTB	MLLT4	A0A151NTY8	A0A151M2L9	Uncharacterized protein.	Afadin isoform F.	0.916
ACTB	RHOA	A0A151NTY8	A0A151MTG6	Uncharacterized protein.	Transforming protein RhoA.	0.926
ACTB	TJP1-2	A0A151NTY8	A0A151MA54	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.912
ACTB	WAS	A0A151NTY8	A0A151M476	Uncharacterized protein.	Wiskott-Aldrich syndrome protein.	0.946
ACTB	Y1Q_0015577	A0A151NTY8	A0A151NNF8	Uncharacterized protein.	Wiskott-Aldrich syndrome protein family member 3-like.	0.928
ACTN1	ACTB	A0A151MB02	A0A151NTY8	Uncharacterized protein.	Uncharacterized protein.	0.938
ACTN1	ACTN4	A0A151MB02	A0A151P6Y2	Uncharacterized protein.	Uncharacterized protein.	0.900
ACTN1	CTNNA2	A0A151MB02	A0A151NQU8	Uncharacterized protein.	Catenin alpha-2 isoform A.	0.923
ACTN1	CTNNA2-2	A0A151MB02	A0A151MYH6	Uncharacterized protein.	Uncharacterized protein.	0.923
ACTN1	Y1Q_0009006	A0A151MB02	A0A151NUJ8	Uncharacterized protein.	Alpha-ketoglutarate-dependent dioxygenase alkB-like protein 7, mitochondrial.	0.900
ACTN4	ACTB	A0A151P6Y2	A0A151NTY8	Uncharacterized protein.	Uncharacterized protein.	0.938
ACTN4	ACTN1	A0A151P6Y2	A0A151MB02	Uncharacterized protein.	Uncharacterized protein.	0.900
ACTN4	CTNNA2	A0A151P6Y2	A0A151NQU8	Uncharacterized protein.	Catenin alpha-2 isoform A.	0.923